1.3.1.85: crotonyl-CoA carboxylase/reductase
This is an abbreviated version!
For detailed information about crotonyl-CoA carboxylase/reductase, go to the full flat file.
Word Map on EC 1.3.1.85
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1.3.1.85
-
polyketide
-
rhodobacter
-
acyl-coas
-
glyoxylate
-
sphaeroides
-
propionyl-coa
-
3-hydroxypropionate
-
extorquens
-
methylobacterium
-
butyryl-coa
- 1.3.1.85
- polyketide
-
rhodobacter
- acyl-coas
- glyoxylate
- sphaeroides
- propionyl-coa
- 3-hydroxypropionate
- extorquens
-
methylobacterium
- butyryl-coa
Reaction
Synonyms
2-octenoyl-CoA carboxylase/reductase, AntE, CCR, CCR1, CCRC, crotonyl-CoA carboxylase/reductase, crotonyl-CoA reductase (carboxylating), crotonyl-CoA reductase-carboxylase, ECR, enoyl-CoA carboxylase/reductase, pteB, rimJ
ECTree
1.3.1.85 crotonyl-CoA carboxylase/reductaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 1.3.1.85 - crotonyl-CoA carboxylase/reductase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(2E)-3-cyclohexylprop-2-enoyl-CoA + NADPH + CO2 + H+
(2S)-2-carboxy-3-cyclohexylpropanoyl-CoA + NADP+
(2E)-4-methylhex-2-enoyl-CoA + NADPH + CO2 + H+
[(2R)-2-methylbutyl]propanedioyl-CoA + NADP+
(2E)-5-chloropent-2-enoyl-CoA + NADPH + CO2 + H+
(2S)-2-carboxy-5-chloropentanoyl-CoA + NADP+
(2E)-5-methylhex-2-enoyl-CoA + NADPH + CO2 + H+
(2S)-(3-methylbutyl)propanedioyl-CoA + NADP+
(2E)-6-methyloct-2-enoyl-CoA + NADPH + CO2 + H+
(2S)-2-carboxy-6-methyloctanoyl-CoA + NADP+
-
-
-
?
(2E)-hept-2-en-6-ynoyl-CoA + NADPH + CO2 + H+
(2S)-2-craboxy-hept-6-ynoyl-CoA + NADP+
-
-
-
?
(2E)-hex-2-enoyl-CoA + NADPH + CO2 + H+
(S)-2-butylpropanedioyl-CoA + NADP+
-
-
-
?
(E)-crotonyl-CoA + CO2 + NADPH + H+
(2S)-ethylmalonyl-CoA + NADP+
-
100% relative specific activity, the carboxylation reaction is the physiologically relevant reaction
-
-
r
(E)-crotonyl-CoA + NADPH + H+
butyryl-CoA + NADP+
-
10% of maximal activity (compared with vmax of crotonyl-CoA carboxylation)
-
-
?
acryloyl-CoA + CO2 + NADPH + H+
methylmalonyl-CoA + NADP+
-
acryloyl-CoA is accepted as an alternative substrate analogue by the enzyme with 40% relative activity (compared with vmax of crotonyl-CoA carboxylation)
-
-
?
(2E)-3-cyclohexylprop-2-enoyl-CoA + NADPH + CO2 + H+
(2S)-2-carboxy-3-cyclohexylpropanoyl-CoA + NADP+
-
-
-
?
(2E)-3-cyclohexylprop-2-enoyl-CoA + NADPH + CO2 + H+
(2S)-2-carboxy-3-cyclohexylpropanoyl-CoA + NADP+
-
-
-
?
(2E)-4-methylhex-2-enoyl-CoA + NADPH + CO2 + H+
[(2R)-2-methylbutyl]propanedioyl-CoA + NADP+
-
-
-
?
(2E)-4-methylhex-2-enoyl-CoA + NADPH + CO2 + H+
[(2R)-2-methylbutyl]propanedioyl-CoA + NADP+
-
-
-
?
(2E)-5-chloropent-2-enoyl-CoA + NADPH + CO2 + H+
(2S)-2-carboxy-5-chloropentanoyl-CoA + NADP+
-
-
-
?
(2E)-5-chloropent-2-enoyl-CoA + NADPH + CO2 + H+
(2S)-2-carboxy-5-chloropentanoyl-CoA + NADP+
-
-
-
?
(2E)-5-methylhex-2-enoyl-CoA + NADPH + CO2 + H+
(2S)-(3-methylbutyl)propanedioyl-CoA + NADP+
-
-
-
?
(2E)-5-methylhex-2-enoyl-CoA + NADPH + CO2 + H+
(2S)-(3-methylbutyl)propanedioyl-CoA + NADP+
-
-
-
?
(2E)-oct-2-enoyl-CoA + NADPH + CO2 + H+
(2S)-2-carboxyoctanoyl-CoA + NADP+
-
-
-
-
?
(2E)-oct-2-enoyl-CoA + NADPH + CO2 + H+
(2S)-2-carboxyoctanoyl-CoA + NADP+
-
-
-
-
?
(2E)-oct-2-enoyl-CoA + NADPH + CO2 + H+
(2S)-2-carboxyoctanoyl-CoA + NADP+
-
-
-
?
3-indolylacryloyl-CoA + NADPH + CO2 + H+
indolylmethylmalonyl-CoA + NADP+
-
-
-
?
3-indolylacryloyl-CoA + NADPH + CO2 + H+
indolylmethylmalonyl-CoA + NADP+
-
-
-
?
4-coumaroyl-CoA + NADPH + CO2 + H+
(2S)2-carboxy-3-(4-hydroxyphenyl)propionyl-CoA + NADP+
-
-
-
?
4-coumaroyl-CoA + NADPH + CO2 + H+
(2S)2-carboxy-3-(4-hydroxyphenyl)propionyl-CoA + NADP+
-
-
-
?
cinnamoyl-CoA + NADPH + CO2 + H+
(2S)2-carboxy-3-phenylpropionyl-CoA + NADP+
-
-
-
?
cinnamoyl-CoA + NADPH + CO2 + H+
(2S)2-carboxy-3-phenylpropionyl-CoA + NADP+
-
-
-
?
crotonyl-CoA + CO2 + NADPH + H+
(2S)-ethylmalonyl-CoA + NADP+
-
-
-
-
r
crotonyl-CoA + CO2 + NADPH + H+
(2S)-ethylmalonyl-CoA + NADP+
-
crotonyl-CoA is the best substrate
-
-
r
crotonyl-CoA + CO2 + NADPH + H+
(2S)-ethylmalonyl-CoA + NADP+
-
-
-
?
crotonyl-CoA + CO2 + NADPH + H+
(2S)-ethylmalonyl-CoA + NADP+
-
-
-
?
crotonyl-CoA + CO2 + NADPH + H+
(2S)-ethylmalonyl-CoA + NADP+
-
-
-
-
r
crotonyl-CoA + CO2 + NADPH + H+
(2S)-ethylmalonyl-CoA + NADP+
-
crotonyl-CoA is the best substrate
-
-
r
crotonyl-CoA + CO2 + NADPH + H+
(2S)-ethylmalonyl-CoA + NADP+
-
-
-
-
r
crotonyl-CoA + CO2 + NADPH + H+
(2S)-ethylmalonyl-CoA + NADP+
-
crotonyl-CoA is the best substrate
-
-
r
crotonyl-CoA + CO2 + NADPH + H+
(2S)-ethylmalonyl-CoA + NADP+
-
-
-
?
crotonyl-CoA + CO2 + NADPH + H+
(2S)-ethylmalonyl-CoA + NADP+
-
-
-
?
crotonyl-CoA + CO2 + NADPH + H+
(2S)-ethylmalonyl-CoA + NADP+
-
-
-
?
crotonyl-CoA + CO2 + NADPH + H+
(2S)-ethylmalonyl-CoA + NADP+
-
-
-
-
?
crotonyl-CoA + CO2 + NADPH + H+
(2S)-ethylmalonyl-CoA + NADP+
-
-
-
-
?
crotonyl-CoA + NADPH + CO2 + H+
(2S)-ethylmalonyl-CoA + NADP+
-
-
-
?
crotonyl-CoA + NADPH + CO2 + H+
(2S)-ethylmalonyl-CoA + NADP+
-
-
-
?
crotonyl-CoA + NADPH + H+
butyryl-CoA + NADP+
-
reduction at low rate
-
-
ir
crotonyl-CoA + NADPH + H+
butyryl-CoA + NADP+
-
reduction at low rate
-
-
ir
crotonyl-CoA + NADPH + H+
butyryl-CoA + NADP+
-
reduction at low rate
-
-
ir
additional information
?
-
-
does not reduce crotonyl-N-acetylcysteamine, methacryloyl-CoA, 6-hydroxycylohex-1-ene-1-carboxyl-CoA, cyclo-hexa-1,5-diene-1-carboxyl-CoA, acetoacetyl-CoA, propionyl-CoA, (R)-3-hydroxybutyryl-CoA, (S)-3-hydroxybutyryl-CoA (less than 1% specific activity)
-
-
?
additional information
?
-
-
the enzyme also catalyzes the reduction of crotonyl-CoA to butyryl-CoA in the absence of CO2, but with only about one tenth of the maximum rate
-
-
?
additional information
?
-
the enzyme catalyzes the reduction of crotonyl-CoA to butyryl-CoA as a side reaction, but only in the absence of CO2 and at low catalytic efficiency
-
-
-
additional information
?
-
the enzyme catalyzes the reduction of crotonyl-CoA to butyryl-CoA as a side reaction, but only in the absence of CO2 and at low catalytic efficiency
-
-
-
additional information
?
-
-
the enzyme also catalyzes the reduction of crotonyl-CoA to butyryl-CoA in the absence of CO2, but with only about one tenth of the maximum rate
-
-
?
additional information
?
-
-
the enzyme also catalyzes the reduction of crotonyl-CoA to butyryl-CoA in the absence of CO2, but with only about one tenth of the maximum rate
-
-
?
