1.3.1.91: tRNA-dihydrouridine20 synthase [NAD(P)+]
This is an abbreviated version!
For detailed information about tRNA-dihydrouridine20 synthase [NAD(P)+], go to the full flat file.
Word Map on EC 1.3.1.91
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1.3.1.91
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dsrnas
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thermus
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d-loops
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thermophilus
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flavin
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carcinogenesis
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dsrbd
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archaea
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trnaphe
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elbow
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l-shaped
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medicine
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synthase-2
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diagnostics
- 1.3.1.91
- dsrnas
-
thermus
-
d-loops
- thermophilus
- flavin
- carcinogenesis
-
dsrbd
- archaea
- trnaphe
-
elbow
-
l-shaped
- medicine
- synthase-2
- diagnostics
Reaction
Synonyms
dihydrouridine synthase, dihydrouridine synthase 2, dihydrouridine synthase C, Dus, DUS 2, DUS2, Dus2p, DusA, DusB, DusC, EcoDusC, hDUS2, HsDus2, SMM1, tRNA-dihydrouridine synthase 2, tRNA-dihydrouridine synthases
ECTree
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Engineering
Engineering on EC 1.3.1.91 - tRNA-dihydrouridine20 synthase [NAD(P)+]
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E294K
the mutation increases the tRNA binding affinity and dihydrouridine activity compared to the wild type enzyme
E294K/Q305K
the mutation increases the tRNA binding affinity and dihydrouridine activity compared to the wild type enzyme
Q305K
the mutation increases the tRNA binding affinity and dihydrouridine activity compared to the wild type enzyme
C117A
rate constant is 1600fold lower than the rate constant of the wild-type enzyme
additional information
siRNA-dependent knockdown of hDus2 decreases colony formation and cell viability of non-small cell lung cancer cells, while hDus2 immunohistochemical staining correlated with patient survival
additional information
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siRNA-dependent knockdown of hDus2 decreases colony formation and cell viability of non-small cell lung cancer cells, while hDus2 immunohistochemical staining correlated with patient survival