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1.3.1.91: tRNA-dihydrouridine20 synthase [NAD(P)+]

This is an abbreviated version!
For detailed information about tRNA-dihydrouridine20 synthase [NAD(P)+], go to the full flat file.

Word Map on EC 1.3.1.91

Reaction

5,6-dihydrouracil20 in tRNA
+
NAD(P)+
=
uracil20 in tRNA
 +
NAD(P)H
 +
H+

Synonyms

dihydrouridine synthase, dihydrouridine synthase 2, dihydrouridine synthase C, Dus, DUS 2, DUS2, Dus2p, DusA, DusB, DusC, EcoDusC, hDUS2, HsDus2, SMM1, tRNA-dihydrouridine synthase 2, tRNA-dihydrouridine synthases

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.91 tRNA-dihydrouridine20 synthase [NAD(P)+]

Engineering

Engineering on EC 1.3.1.91 - tRNA-dihydrouridine20 synthase [NAD(P)+]

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
E294K
the mutation increases the tRNA binding affinity and dihydrouridine activity compared to the wild type enzyme
E294K/Q305K
the mutation increases the tRNA binding affinity and dihydrouridine activity compared to the wild type enzyme
Q305K
the mutation increases the tRNA binding affinity and dihydrouridine activity compared to the wild type enzyme
C117A
rate constant is 1600fold lower than the rate constant of the wild-type enzyme
additional information