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1.3.1.98: UDP-N-acetylmuramate dehydrogenase

This is an abbreviated version!
For detailed information about UDP-N-acetylmuramate dehydrogenase, go to the full flat file.

Word Map on EC 1.3.1.98

Reaction

UDP-N-acetyl-alpha-D-muramate
+
NADP+
=
UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine
+
NADPH
+
H+

Synonyms

alr5066, EC 1.1.1.158, More, MurB, MurBAb, PA2977, PaMurB, reductase, uridine diphosphoacetylpyruvoylglucosamine, type I UNAGEP reductase, UDP-GlcNAc-enoylpyruvate reductase, UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylenolpyruvyl glucosamine reductase, UDP-N-acetylenolpyruvylglucosamine reductase, UDP-N-acetylglucosamine-enoylpyruvate reductase, UDP-N-acetylmuramate dehydrogenase, UNAGEP reductase, uridine diphospho-N-acetylglucosamine-enolpyruvate reductase, uridine-5'-diphospho-N-acetyl-2-amino-2-deoxy-3-O-lactylglucose:NADP-oxidoreductase, VspiD_010100018130

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.98 UDP-N-acetylmuramate dehydrogenase

IC50 Value

IC50 Value on EC 1.3.1.98 - UDP-N-acetylmuramate dehydrogenase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.05
(4S)-1,2-bis(4-chlorophenyl)-5-[2-(2,4-difluorophenyl)-2-oxoethoxy]-4-methylpyrazolidin-3-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.0072
1,2-bis(4-chlorophenyl)-4,4-bis(6-phenylhexyl)pyrazolidine-3,5-dione
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.0058
1,2-bis(4-chlorophenyl)-4,4-bis[2-(2,4-difluorophenyl)-2-oxoethyl]pyrazolidine-3,5-dione
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.011
1,2-bis(4-chlorophenyl)-4-(2,4-dichlorobenzyl)pyrazolidine-3,5-dione
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.05
1,2-bis(4-chlorophenyl)-4-(2-ethylbutyl)pyrazolidine-3,5-dione
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.035 - 0.05
1,2-bis(4-chlorophenyl)-4-(2-phenylethyl)pyrazolidine-3,5-dione
0.05
1,2-bis(4-chlorophenyl)-4-(3-methoxybenzyl)pyrazolidine-3,5-dione
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.013
1,2-bis(4-chlorophenyl)-4-(3-oxo-3-phenylpropyl)pyrazolidine-3,5-dione
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.01
1,2-bis(4-chlorophenyl)-4-(3-phenylpropyl)pyrazolidine-3,5-dione
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.01
1,2-bis(4-chlorophenyl)-4-(4-oxo-4-phenylbutyl)pyrazolidine-3,5-dione
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.0056
1,2-bis(4-chlorophenyl)-4-(4-phenylbutyl)pyrazolidine-3,5-dione
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.01
1,2-bis(4-chlorophenyl)-4-(5-phenylpentyl)pyrazolidine-3,5-dione
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.0089
1,2-bis(4-chlorophenyl)-4-(6-phenylhexyl)pyrazolidine-3,5-dione
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.042
1,2-bis(4-chlorophenyl)-4-heptylpyrazolidine-3,5-dione
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.049
1,2-bis(4-chlorophenyl)-4-[2-(2,4-difluorophenyl)-2-oxoethyl]-4-methylpyrazolidine-3,5-dione
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.0054
1,2-bis(4-chlorophenyl)-4-[2-(4-fluorophenyl)-2-oxoethyl]pyrazolidine-3,5-dione
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.05
1,2-bis(4-chlorophenyl)-4-[2-(diethylamino)ethyl]pyrazolidine-3,5-dione
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.018
1,2-bis(4-chlorophenyl)-4-[3-(trifluoromethyl)benzyl]pyrazolidine-3,5-dione
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.011
4'-[[1,2-bis(4-chlorophenyl)-3,5-dioxopyrazolidin-4-yl]methyl]biphenyl-2-carbonitrile
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.0072
4,4-bis[2-(benzyloxy)ethyl]-1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.05
4-(2-chlorobenzyl)-1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.05
4-benzyl-1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.02
4-[2-(benzyloxy)ethyl]-1,2-bis(4-chlorophenyl)-4-methylpyrazolidine-3,5-dione
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.011
4-[2-(benzyloxy)ethyl]-1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.0052
4-[2-(benzylsulfanyl)ethyl]-1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.05
4-[2-[benzyl(ethyl)amino]ethyl]-1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.012
4-[3,5-bis(trifluoromethyl)benzyl]-1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione
Mycobacterium tuberculosis
pH and temperature not specified in the publication