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1.3.2.3: L-galactonolactone dehydrogenase

This is an abbreviated version!
For detailed information about L-galactonolactone dehydrogenase, go to the full flat file.

Word Map on EC 1.3.2.3

Reaction

L-galactono-1,4-lactone
+
2 ferricytochrome c
=
L-ascorbate
+ 2 ferrocytochrome c + 2 H+

Synonyms

dehydrogenase, galactonolactone, ferricytochrome c oxidoreductase, galactono-1,4-lactone dehydrogenase, galactonolactone dehydrogenase, GALDH, GalL dehydrogenase, GalLDH, GLDase, GLDH, GLDH-A1, GLDH-B1, GLDH-D1, GLDH1, GLDHase, L-galactone-1,4-lactone dehydrogenase, L-galactono-1, 4-lactone dehydrogenase, L-galactono-1,4-lactone dehydrogenase, L-galactono-gamma-lactone dehydrogenase, L-GalLDH, L-GalLDH1, L-GalLDH2, LsL-GalLDH, RrGalLDH

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.2 With a cytochrome as acceptor
                1.3.2.3 L-galactonolactone dehydrogenase

Systematic Name

Systematic Name on EC 1.3.2.3 - L-galactonolactone dehydrogenase

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SYSTEMATIC NAME
IUBMB Comments
L-galactono-1,4-lactone:ferricytochrome-c oxidoreductase
This enzyme catalyses the final step in the biosynthesis of L-ascorbic acid in higher plants and in nearly all higher animals with the exception of primates and some birds [5]. The enzyme is very specific for its substrate L-galactono-1,4-lactone as D-galactono-gamma-lactone, D-gulono-gamma-lactone, L-gulono-gamma-lactone, D-erythronic-gamma-lactone, D-xylonic-gamma-lactone, L-mannono-gamma-lactone, D-galactonate, D-glucuronate and D-gluconate are not substrates [5]. FAD, NAD+, NADP+ and O2 (cf. EC 1.3.3.12, L-galactonolactone oxidase) cannot act as electron acceptor [5].