1.3.3.13: albonoursin synthase
This is an abbreviated version!
For detailed information about albonoursin synthase, go to the full flat file.
Reaction
Synonyms
AlbA, cyclic dipeptide oxidase, cyclo(dipeptide):oxygen oxidoreductase
ECTree
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Substrates Products
Substrates Products on EC 1.3.3.13 - albonoursin synthase
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REACTION DIAGRAM
cyclo(L-Leu-L-Ala) + O2
?
13% mono-dehydro-products and 4% bis-dehydro products
-
-
?
cyclo(L-Phe-Gly) + O2
(3Z)-3-benzylidenepiperazine-2,5-dione + H2O2
36% mono-dehydro-products and no bis-dehydro products
-
-
?
cyclo(L-Phe-L-His) + O2
?
21% mono-dehydro-products and less than 1% bis-dehydro products
-
-
?
cyclo(L-Ser-Gly) + O2
(3Z)-3-(2-hydroxyethylidene)piperazine-2,5-dione + H2O2
11% mono-dehydro-products and no bis-dehydro products
-
-
?
cyclo(L-Trp-L-Trp) + O2
?
74% mono-dehydro-products and 14% bis-dehydro products
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-
?
cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + O2
albonoursin + H2O2
-
-
-
?
cyclo(L-4-O-methyltyrosine-L-leucine) + 2 O2
? + 2 H2O2
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-
-
-
?
(4Z)-4-(3,6-dioxopiperazin-2-yl)butanoate + H2O2
3% mono-dehydro-products and no bis-dehydro products
-
-
?
cyclo(L-Glu-Gly) + O2
(4Z)-4-(3,6-dioxopiperazin-2-yl)butanoate + H2O2
3% mono-dehydro-products and no bis-dehydro products
-
-
?
(3Z)-3-(2-methylpropylidene)piperazine-2,5-dione + H2O2
9% mono-dehydro-products and no bis-dehydro products
-
-
?
cyclo(L-Leu-Gly) + O2
(3Z)-3-(2-methylpropylidene)piperazine-2,5-dione + H2O2
9% mono-dehydro-products and no bis-dehydro products
-
-
?
albonoursin + H2O2
the catalytic reaction of the natural substrate cyclo(L-leucyl-L-phenylalanyl) occurs in a two-step sequential reaction leading first to cyclo(alpha,beta-dehydro-Phe-L-Leu) and finally to albonoursin
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-
?
cyclo(L-Leu-L-Phe) + O2
albonoursin + H2O2
the catalytic reaction of the natural substrate cyclo(L-leucyl-L-phenylalanyl) occurs in a two-step sequential reaction leading first to cyclo(alpha,beta-dehydro-Phe-L-Leu) and finally to albonoursin
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-
?
cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + H2O2
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-
-
?
cyclo(L-Leu-L-Phe) + O2
cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + H2O2
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-
-
?
cyclo(L-leucyl-L-phenylalanyl) + 2 O2
albonoursin + 2 H2O2
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-
-
-
?
?
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-
albonoursin is then methoxylated to cyclo(L-methoxytyrosine-L-leucine) by O-methyltranferases, encoded by genes B005_4460 and B005_4464, termed albM1 and albM2
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-
?
additional information
?
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albonoursin is then methoxylated to cyclo(L-methoxytyrosine-L-leucine) by O-methyltranferases, encoded by genes B005_4460 and B005_4464, termed albM1 and albM2
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?
additional information
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no activity towards N-acetyl-L-Phe-L-Leu and N-actely-L-Leu-L-Phe
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?
additional information
?
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no activity towards N-acetyl-L-Phe-L-Leu and N-actely-L-Leu-L-Phe
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?
additional information
?
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no activity towards N-acetyl-L-Phe-L-Leu and N-actely-L-Leu-L-Phe
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-
?