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1.3.8.7: medium-chain acyl-CoA dehydrogenase

This is an abbreviated version!
For detailed information about medium-chain acyl-CoA dehydrogenase, go to the full flat file.

Word Map on EC 1.3.8.7

Reaction

a medium-chain acyl-CoA
+
electron-transfer flavoprotein
=
a medium-chain trans-2,3-dehydroacyl-CoA
 +
reduced electron-transfer flavoprotein

Synonyms

ACAD-9, ACADM, ACD, acyl CoA dehydrogenase, acyl coenzyme A dehydrogenase, acyl dehydrogenase, acyl-CoA dehydrogenase, acyl-CoA dehydrogenase-9, dehydrogenase, acyl coenzyme A, EC 1.3.2.2, EC 1.3.99.3, FadE, fatty acyl coenzyme A dehydrogenase, fatty-acyl-CoA dehydrogenase, general ACAD, general acyl CoA dehydrogenase, LCAD, LipB, MCAD, MCADH, medium chain acyl-CoA dehydrogenase, medium chain-specific acyl-CoA oxidase, medium-chain acyl CoA dehydrogenase, medium-chain acyl-CoA dehydrogenase, medium-chain acyl-coenzyme A dehydrogenase, medium-chain coenzyme A dehydrogenase, pMCAD, PP_1893, PP_2039, PP_2048, PP_2437

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.8 With a flavin as acceptor
                1.3.8.7 medium-chain acyl-CoA dehydrogenase

Substrates Products

Substrates Products on EC 1.3.8.7 - medium-chain acyl-CoA dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,16,19-docosahexaenoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
?
(5Z,8Z,11Z,14Z,17Z) -5,8,11,14,17-icosapentaenoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
?
2,6-dimethylheptanoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
?
4,8,12-trimethyltridecanoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
?
4-cis,7-cis-decadienoyl-CoA + Meldola's Blue + iodonitrotetrazoliumchloride
2-trans,4-cis,7cis-decatrienoyl-CoA + reduced acceptor
show the reaction diagram
-
cis-double bond has almost no effect on velocity of general acyl-CoA dehydrogenase
-
?
4-cis-decenoyl-CoA + Meldola's Blue + iodonitrotetrazoliumchloride
2-trans,4-cis-decadienoyl-CoA + reduced acceptor
show the reaction diagram
-
cis-double bond has almost no effect on velocity of general acyl-CoA dehydrogenase
-
?
4-decynoyl-CoA + Meldola's Blue + iodonitrotetrazoliumchloride
trans-2-ene-4-decynoyl-CoA + reduced acceptor
show the reaction diagram
-
cis-double bond has almost no effect on velocity of general acyl-CoA dehydrogenase
-
?
4-oxaoctanoyl-CoA + phenazine methosulfate + 2,6-dichlorophenolindophenol
4-thia-trans-2-octenoyl-CoA + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
-
poor substrate, oxidized at about 10% of the rate of octanoyl-CoA
-
?
4-thiaoctanoyl-CoA + phenazine methosulfate + 2,6-dichlorophenolindophenol
4-thia-trans-2-octenoyl-CoA + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
-
oxidized 1.5fold faster than octanoyl-CoA
-
?
5-cis-decenoyl-CoA + Meldola's Blue + iodonitrotetrazoliumchloride
2-trans,5-cis-decadienoyl-CoA + reduced acceptor
show the reaction diagram
-
cis-double bond has almost no effect on velocity of general acyl-CoA dehydrogenase
-
?
6-cis-decenoyl-CoA + Meldola's Blue + iodonitrotetrazoliumchloride
2-trans,6-cis-decadienoyl-CoA + reduced acceptor
show the reaction diagram
-
cis-double bond has almost no effect on velocity of general acyl-CoA dehydrogenase
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
show the reaction diagram
acyl-CoA + electron transfer flavoprotein
2,3-dehydroacyl-CoA + reduced electron transfer flavoprotein
show the reaction diagram
all-cis-4,7,10,13-hexadecatetraenoyl-CoA + Meldola's Blue + iodonitrotetrazoliumchloride
2-trans-all-cis-4,7,10,13-hexadecapentaenoyl-CoA + reduced acceptor
show the reaction diagram
-
cis-double bond has almost no effect on velocity of general acyl-CoA dehydrogenase
-
?
arachidonoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
?
arachidoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
?
beta-(2-furyl)propionyl-CoA + electron transfer flavoprotein + 2,6-dichloroindophenol
trans-beta-(2-furyl)acryloyl-CoA + reduced acceptor
show the reaction diagram
beta-(2-furyl)propionyl-CoA + O2
trans-beta-(2-furyl)acryloyl-CoA + H2O2
show the reaction diagram
-
slow oxidase activity
-
?
beta-(2-furyl)propionyl-CoA + pyocyanine
trans-beta-(2-furyl)acryloyl-CoA + reduced pyocanine
show the reaction diagram
-
-
-
?
butanoyl-CoA + acceptor
crotonyl-CoA + reduced acceptor
show the reaction diagram
butanoyl-CoA + electron-transfer flavoprotein
crotonoyl-CoA + reduced electron-transfer flavoprotein
show the reaction diagram
-
-
-
-
r
crotonyl-CoA + H2O
L-3-hydroxy-butyryl-CoA
show the reaction diagram
-
enoyl-CoA hydratase activity
-
?
decanoyl-CoA + 2,6-dichlorophenolindophenol
2-decenoyl-CoA + reduced 2,6-dichorophenolindophenol
show the reaction diagram
-
-
-
-
r
decanoyl-CoA + acceptor
2-decenoyl-CoA + reduced acceptor
show the reaction diagram
decanoyl-CoA + electron transfer flavoprotein
(2E)-2-decenoyl-CoA + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
?
decanoyl-CoA + electron transfer flavoprotein
decenoyl-CoA + reduced electron transfer flavoprotein
show the reaction diagram
decanoyl-CoA + ferricenium hexafluorophosphate
2-decenoyl-CoA + ferrocenium hexafluorophosphate
show the reaction diagram
-
-
-
-
r
decanoyl-CoA + ferrocenium hexafluorophosphate
trans-dec-2-enoyl-CoA + reduced ferrocenium hexafluorophosphate
show the reaction diagram
-
-
-
-
r
decanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol
2-trans-decenoyl-CoA + reduced acceptor
show the reaction diagram
docosanoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
?
dodecanoyl-CoA + acceptor
2-dodecenoyl-CoA + reduced acceptor
show the reaction diagram
dodecanoyl-CoA + electron transfer flavoprotein
dodecenoyl-CoA + reduced electron transfer flavoprotein
show the reaction diagram
dodecanoyl-CoA + electron-transfer flavoprotein
+ trans-dodec-2-enoyl-CoA reduced electron-transfer flavoprotein
show the reaction diagram
-
-
-
-
r
dodecanoyl-CoA + tetrazolium salt
trans-dodec-2-enoyl-CoA + reduced tetrazolium salt
show the reaction diagram
-
-
-
-
r
elaidoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
?
furylpropionyl-CoA + ferricenium hexafluorophosphate
furylacryloyl-CoA + ferrocenium hexafluorophosphate
show the reaction diagram
heptadecan-2-onyl-dethio-CoA + phenazine methosulfate + 2,6-dichloroindophenol
?
show the reaction diagram
heptadecanoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
?
hexadecanoyl-CoA + acceptor
2-hexadecenoyl-CoA + reduced acceptor
show the reaction diagram
hexadecanoyl-CoA + Meldola's Blue + iodonitrotetrazoliumchloride
2-trans-hexadecenoyl-CoA + reduced acceptor
show the reaction diagram
hexanoyl-CoA + 2,6-dichloroindophenol
2-hexenoyl-CoA + reduced 2,6-dichloroindophenol
show the reaction diagram
-
-
-
-
?
hexanoyl-CoA + 2,6-dichlorophenolindophenol
trans-hex-2-enoyl-CoA + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
-
-
-
-
r
hexanoyl-CoA + acceptor
2-hexenoyl-CoA + reduced acceptor
show the reaction diagram
hexanoyl-CoA + electron transfer flavoprotein
(2E)-2-hexenoyl-CoA + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
?
hexanoyl-CoA + ferricenium
trans-hex-2-enoyl-CoA + ferrocenium
show the reaction diagram
-
-
-
-
r
hexanoyl-CoA + ferricenium hexafluorophosphate
trans-hex-2-enoyl-CoA + ferrocenium hexafluorophosphate
show the reaction diagram
-
-
-
-
r
hexanoyl-CoA + ferrocenium hexafluorophosphate
trans-hex-2-enoyl-CoA + reduced ferrocenium hexafluorophosphate
show the reaction diagram
-
-
-
-
r
hexanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol
2-trans-hexenoyl-CoA + reduced acceptor
show the reaction diagram
-
-
-
?
hexanoyl-CoA + tetrazolium salt
trans-hex-2-enoyl-CoA + reduced tetrazolium salt
show the reaction diagram
-
-
-
-
r
indolepropionyl-CoA + ferricenium hexafluorophosphate
indoleacryloyl-CoA + ferrocenium hexafluorophosphate
show the reaction diagram
indolepropionyl-CoA + O2
indoleacryloyl-CoA + H2O2
show the reaction diagram
lauroyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
?
lauroyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol
2-trans-dodecenoyl-CoA + reduced acceptor
show the reaction diagram
-
-
-
?
linoleoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
?
myristoleoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
?
myristoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
?
n-octanoyl-CoA + acceptor
2-octenoyl-CoA + reduced acceptor
show the reaction diagram
-
-
-
-
?
n-octanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol
2-octenoyl-CoA + reduced acceptor
show the reaction diagram
n-tetradecanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol
2-tetradecenoyl-CoA + reduced acceptor
show the reaction diagram
nonanoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
?
octadecanoyl-CoA + acceptor
2-octadecenoyl-CoA + reduced acceptor
show the reaction diagram
octanoyl 3'-dephospho-CoA + 2,6-dichloroindophenol
?
show the reaction diagram
-
-
-
-
?
octanoyl pantetheine + 2,6-dichloroindophenol
?
show the reaction diagram
-
-
-
-
?
octanoyl-1,N6-etheno-CoA + 2,6-dichloroindophenol
?
show the reaction diagram
-
-
-
-
?
octanoyl-CoA + 2,6-dichloroindophenol
2-octenoyl-CoA + reduced 2,6-dichloroindophenol
show the reaction diagram
-
optimal substrate for wild type enzyme
-
-
?
octanoyl-CoA + acceptor
2-octenoyl-CoA + reduced acceptor
show the reaction diagram
octanoyl-CoA + electron transferring flavoprotein
2-octenoyl-CoA + reduced electron transferring flavoprotein
show the reaction diagram
octanoyl-CoA + ferricenium
2-octenoyl-CoA + reduced acceptor
show the reaction diagram
octanoyl-CoA + ferricenium hexafluorophosphate
2-octenoyl-CoA + ferrocenium hexafluorophosphate
show the reaction diagram
-
medium chain acyl-CoA dehydrogenase from kidney
-
?
octanoyl-CoA + ferriocenium hexfluorophosphate
2-octenoyl-CoA + reduced acceptor
show the reaction diagram
-
-
-
-
?
octanoyl-CoA + meldola's blue
trans-oct-2-enoyl-CoA + reduced meldola's blue
show the reaction diagram
-
-
-
-
r
octanoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
?
octanoyl-CoA + phenazine ethosulfate
trans-oct-2-enoyl-CoA + reduced phenazine ethosulfate
show the reaction diagram
-
-
-
-
r
octanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol
2-octenoyl-CoA + reduced acceptor
show the reaction diagram
-
-
-
-
?
octanoyl-CoA + recombinant beta-Y16L electron transferring flavoprotein
trans-oct-2-enoyl-CoA + reduced recombinant beta-Y16L electron transferring flavoprotein
show the reaction diagram
-
-
-
-
r
octanoyl-CoA + recombinant electron transferring flavoprotein
trans-oct-2-enoyl-CoA + reduced recombinant electron transferring flavoprotein
show the reaction diagram
-
-
-
-
r
oleoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
?
palmitoleoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
?
palmitoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
?
pentadecanoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
?
pentanoyl-CoA + acceptor
2-pentenoyl-CoA + reduced acceptor
show the reaction diagram
phenylpropionyl-CoA + acceptor
? + reduced acceptor
show the reaction diagram
phenylpropionyl-CoA + ferricenium hexafluorophosphate
? + reduced ferricenium hexafluorophosphate
show the reaction diagram
-
-
-
-
?
stearoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
?
tetradecanoyl-CoA + acceptor
2-tetradecenoyl-CoA + reduced acceptor
show the reaction diagram
tetradecanoyl-CoA + electron transfer flavoprotein
tetradecenoyl-CoA + reduced electron transfer flavoprotein
show the reaction diagram
tetradecanoyl-CoA + tetrazolium salt
tetradecenoyl-CoA + reduced tetrazolium salt
show the reaction diagram
-
-
-
-
r
tetradecenoyl-CoA + reduced electron transfer flavoprotein
tetradecanoyl-CoA + electron transfer flavoprotein
show the reaction diagram
-
-
-
-
r
undecanoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
?
[4-(dimethylamino)phenyl]propionyl-CoA + ferricenium hexafluorophosphate
4-(dimethylamino)cinnamoyl-CoA + ferrocenium hexafluorophosphate
show the reaction diagram
additional information
?
-