1.3.8.7: medium-chain acyl-CoA dehydrogenase

This is an abbreviated version!
For detailed information about medium-chain acyl-CoA dehydrogenase, go to the full flat file.

Reaction

Synonyms

ACAD-9, ACADM, ACD, acyl CoA dehydrogenase, acyl coenzyme A dehydrogenase, acyl dehydrogenase, acyl-CoA dehydrogenase, acyl-CoA dehydrogenase-9, dehydrogenase, acyl coenzyme A, EC 1.3.2.2, EC 1.3.99.3, FadE, fatty acyl coenzyme A dehydrogenase, fatty-acyl-CoA dehydrogenase, general ACAD, general acyl CoA dehydrogenase, LCAD, LipB, MCAD, MCADH, medium chain acyl-CoA dehydrogenase, medium chain-specific acyl-CoA oxidase, medium-chain acyl CoA dehydrogenase, medium-chain acyl-CoA dehydrogenase, medium-chain acyl-coenzyme A dehydrogenase, medium-chain coenzyme A dehydrogenase, pMCAD, PP_1893, PP_2039, PP_2048, PP_2437

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.8 With a flavin as acceptor

                1.3.8.7 medium-chain acyl-CoA dehydrogenase

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Results	in table
2	Activating Compound
12485	AA Sequence
13	Application
1	CAS Registry Number
19	Cloned(Commentary)
28	Cofactor
8	Crystallization (Commentary)
2577	Disease/ Diagnostics
9	General Information
3	General Stability
58	Inhibitors
14	Ki Value [mM]
117	KM Value [mM]
17	Localization
25	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
120	Organism
10	Pathway
4	PDB ID
7	pH Optimum
4	pH Range
1	pH Stability
78	Protein Variants
29	Purification (Commentary)
9	Reaction
5	Reaction Type
114	Reference
73	Source Tissue
19	Specific Activity [micromol/min/mg]
11	Storage Stability
210	Substrates and Products (Substrate)
19	Subunits
83	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
16	Temperature Stability [°C]
84	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.3.8.7 - medium-chain acyl-CoA dehydrogenase

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SYSTEMATIC NAME

IUBMB Comments

medium-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Contains FAD as prosthetic group. One of several enzymes that catalyse the first step in fatty acids beta-oxidation. The enzyme from pig liver can accept substrates with acyl chain lengths of 4 to 16 carbon atoms, but is most active with C8 to C12 compounds [2]. The enzyme from rat does not accept C16 at all and is most active with C6-C8 compounds [4]. cf. EC 1.3.8.1, short-chain acyl-CoA dehydrogenase, EC 1.3.8.8, long-chain acyl-CoA dehydrogenase, and EC 1.3.8.9, very-long-chain acyl-CoA dehydrogenase.