1.3.98.1: dihydroorotate dehydrogenase (fumarate)

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For detailed information about dihydroorotate dehydrogenase (fumarate), go to the full flat file.

Reaction

Synonyms

(DHO) dehydrogenase, 4,5-L-dihydroorotate:oxygen oxidoreductase, ACT/DHOD, class 1A DHOD, class 1A DHODH, class 1A dihydroorotate dehydrogenase, DHOD, DHOD1, DHOD2, DHOD3, DHODA, DHOdehase, DHODH, DHODH-1A, dihydroorotate dehydrogenase, dihydroorotate dehydrogenase class 1A, Dihydroorotate oxidase, EC 1.3.3.1, LmDHODH, More, oxidase, dihydroorotate, TcDHOD

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.98 With other, known, physiological acceptors

                1.3.98.1 dihydroorotate dehydrogenase (fumarate)

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Systematic Name

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Systematic Name on EC 1.3.98.1 - dihydroorotate dehydrogenase (fumarate)

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SYSTEMATIC NAME

IUBMB Comments

(S)-dihydroorotate:fumarate oxidoreductase

Binds FMN. The reaction, which takes place in the cytosol, is the only redox reaction in the de novo biosynthesis of pyrimidine nucleotides. Molecular oxygen can replace fumarate in vitro. Other class 1 dihydroorotate dehydrogenases use either NAD+ (EC 1.3.1.14) or NADP+ (EC 1.3.1.15) as electron acceptor. The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor.