1.3.99.4: 3-oxosteroid 1-dehydrogenase

This is an abbreviated version!
For detailed information about 3-oxosteroid 1-dehydrogenase, go to the full flat file.

Reaction

Synonyms

1-ene-dehydrogenase, 3-keto-5alpha-steroid DELTA(1)-dehydrogenase, 3-ketosteroid 1(2)-dehydrogenase, 3-ketosteroid delta1-dehydrogenase, 3-ketosteroid-1-en-dehydrogenase, 3-ketosteroid-D1-dehydrogenase, 3-ketosteroid-DELTA1-dehydrogenase, 3-ketosteroid-DELTA1-dehydrogenases, 3-oxosteroid D1-dehydrogenase, 3-oxosteroid Delta1-dehydrogenase, 3-oxosteroid:(2,6-dichlorphenolindophenol) DELTA1-oxidoreductase, 3-oxosteroid:(2,6-dichlorphenolindophenol)D1-oxidoreductase, 4-en-3-oxosteroid:(acceptor)-1-en-oxido-reductase, 4-ene-3-oxosteroid: (acceptor)-1-ene-oxoreductase, 4-ene-3-oxosteroid:(acceptor)l-ene-oxidoreductase, AcmB, AcmB2, cholest-4-en-3-one DELTA1-dehydrogenase, D1-dehydrogenase, D1-steroid reductase, dehydrogenase, 3-oxo steroid Delta 1-, Delta1-dehydrogenase, DELTA1-KstD, DELTA1-KSTD1, DELTA1-KstDA, DELTA1-KstDR, DELTA1-steroid reductase, ketosteroid DELTA1-dehydrogenase, KsdD, KsdD1, KsdD2, KsdD3, KsdD5, KsdDM, KSDH, KstD, KSTD1, KSTD2, KSTD3, KSTD3 orthologue, KstDF, MnKstD1, MnKstD2, MsKstD1, MsKstD2, MsKstD3, MsKstD4, ReKstD1, Rv3537, steroid-1-dehydrogenase

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.99 With unknown physiological acceptors

                1.3.99.4 3-oxosteroid 1-dehydrogenase

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Results	in table
11	Activating Compound
1430	AA Sequence
20	Application
1	CAS Registry Number
36	Cloned(Commentary)
24	Cofactor
2	Crystallization (Commentary)
4	Expression
42	General Information
5	General Stability
42	Inhibitors
45	kcat/KM [mM/s]
135	KM Value [mM]
9	Localization
9	Metals/Ions
10	Molecular Weight [Da]
65	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
547	Organism
8	Pathway
18	PDB ID
24	pH Optimum
4	pH Range
5	pH Stability
3	pI Value
58	Protein Variants
19	Purification (Commentary)
4	Reaction
3	Reaction Type
107	Reference
31	Specific Activity [micromol/min/mg]
4	Storage Stability
341	Substrates and Products (Substrate)
32	Subunits
232	Synonyms
1	Systematic Name
18	Temperature Optimum [°C]
3	Temperature Range [°C]
10	Temperature Stability [°C]
56	Turnover Number [1/s]

Expression

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Expression on EC 1.3.99.4 - 3-oxosteroid 1-dehydrogenase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

construction of a mutant Mtb H37Rv strain containing an inactivated kstD gene, DELTAkstD, which encodes 3-ketosteroid 1(2)-dehydrogenase by homologous recombination-based gene-replacement technique. Replication of mutant Mycobacterium tuberculosis is attenuated in resting human macrophages compared to the wild-type or complemented strains. The mutant is unable to inhibit the NO and reactive oxygen species production induced through Toll-like receptor 2 signaling in infected resting macrophages. But mutant and wild-type Mycobacterium tuberculosis behave similarly in macrophages activated with IFN-gamma before and during infection. The mutant is unable to use cholesterol as a source of carbon and energy and has a limited ability to multiply

2 entries

the enzyme is induced during the bacterial growth on 17alpha-methyl-testosterone

2 entries

construction of a mutant Mtb H37Rv strain containing an inactivated kstD gene, DELTAkstD, which encodes 3-ketosteroid 1(2)-dehydrogenase by homologous recombination-based gene-replacement technique. Replication of mutant Mycobacterium tuberculosis is attenuated in resting human macrophages compared to the wild-type or complemented strains. The mutant is unable to inhibit the NO and reactive oxygen species production induced through Toll-like receptor 2 signaling in infected resting macrophages. But mutant and wild-type Mycobacterium tuberculosis behave similarly in macrophages activated with IFN-gamma before and during infection. The mutant is unable to use cholesterol as a source of carbon and energy and has a limited ability to multiply

Mycobacterium tuberculosis

-

724670

construction of a mutant Mtb H37Rv strain containing an inactivated kstD gene, DELTAkstD, which encodes 3-ketosteroid 1(2)-dehydrogenase by homologous recombination-based gene-replacement technique. Replication of mutant Mycobacterium tuberculosis is attenuated in resting human macrophages compared to the wild-type or complemented strains. The mutant is unable to inhibit the NO and reactive oxygen species production induced through Toll-like receptor 2 signaling in infected resting macrophages. But mutant and wild-type Mycobacterium tuberculosis behave similarly in macrophages activated with IFN-gamma before and during infection. The mutant is unable to use cholesterol as a source of carbon and energy and has a limited ability to multiply

Mycobacterium tuberculosis H37Rv

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-

the enzyme is induced during the bacterial growth on 17alpha-methyl-testosterone

Rhodococcus erythropolis

Q9RA02

763042

the enzyme is induced during the bacterial growth on 17alpha-methyl-testosterone

Rhodococcus erythropolis SQ1

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