1.4.1.1: alanine dehydrogenase
This is an abbreviated version!
For detailed information about alanine dehydrogenase, go to the full flat file.
Word Map on EC 1.4.1.1
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1.4.1.1
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burn
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children
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postburn
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sham
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full-thickness
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flame
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admitted
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superficial
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admission
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resuscitation
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injured
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trauma
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sepsis
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inflict
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burn-induced
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ringer
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sacrificed
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third-degree
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anesthetized
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immersion
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xanthomonas
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barley
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child
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demographic
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dress
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partial-thickness
-
victim
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sugarcane
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accident
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home
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second-degree
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xylella
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dorsum
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work-related
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postinjury
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thermostat
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epithelialization
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debridement
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hereinafter
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1-methylcyclopropene
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biotechnology
-
synthesis
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fastidiosa
-
heater
-
toddler
-
hypermetabolic
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delicious
-
guadeloupe
-
kitchen
-
diphenylamine
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medicine
-
eschar
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nutrition
-
analysis
-
shower
- 1.4.1.1
-
burn
- children
-
postburn
-
sham
-
full-thickness
-
flame
-
admitted
-
superficial
-
admission
-
resuscitation
-
injured
-
trauma
-
sepsis
-
inflict
-
burn-induced
-
ringer
-
sacrificed
-
third-degree
-
anesthetized
-
immersion
-
xanthomonas
- barley
- child
-
demographic
-
dress
-
partial-thickness
-
victim
-
sugarcane
-
accident
-
home
-
second-degree
-
xylella
-
dorsum
-
work-related
-
postinjury
-
thermostat
-
epithelialization
-
debridement
-
hereinafter
- 1-methylcyclopropene
- biotechnology
- synthesis
-
fastidiosa
-
heater
-
toddler
-
hypermetabolic
-
delicious
-
guadeloupe
-
kitchen
- diphenylamine
- medicine
-
eschar
- nutrition
- analysis
-
shower
Reaction
Synonyms
(S)alanine dehydrogenase, (S)alanine:NAD oxidoreductase, 40 kDa antigen, ADH, AF1665, ALADH, alanine dehydrogenase, alanine oxidative deaminase, alanine oxidoreductase, ALD, AldA, alpha-alanine dehydrogenase, ApalaDH, AsAlaDH, CQA66_00465, dehydrogenase, alanine, glyoxylate reductive aminase, GxrA, HAADH1, HAADH2, L-Ala dehydrogenase, L-AlaDH, L-AlaDH-Bs, L-alanine dehydrogenase, MtbALD, NAD(H)-dependent L-alanine dehydrogenase, NAD+ dependent amino acid dehydrogenase, NAD+-dependent alanine dehydrogenase, NAD-dependent alanine dehydrogenase, NAD-linked alanine dehydrogenase, NADH-dependent alanine dehydrogenase, OF4Ald, PlaAlaDH, PvRA, pyruvate reductive aminase, Rv2780, ScALD, SCO1773, SheAlaDH, TB43
ECTree
1.4.1.1 alanine dehydrogenaseAdvanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 1.4.1.1 - alanine dehydrogenase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-isoleucine + H2O + NAD+
2-oxo-3-methylpentanoate + NH3 + NADH + H+
-
-
-
-
r
L-serine + H2O + NAD+
3-hydroxypyruvate + NH3 + NADH + NH3 + NADH + H+
-
-
-
-
r
L-threonine + H2O + NAD+
3-hydroxy-2-oxobutyrate + NH3 + NADH + H+
-
-
-
-
r
pyruvate + NH3 + NADH
L-Ala + NAD+ + H2O
-
primary route for alanine synthesis in isolated bacteroids, alanine synthesis and secretion contributes to the efficiency of N2-fixation and therefore biomass accumulation
-
-
?
glyoxylate + NH3 + NADH + H+
glycine + H2O + NAD+
-
-
-
ir
glyoxylate + NH3 + NADH + H+
glycine + H2O + NAD+
-
-
-
ir
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
the physiological role is to catabolize L-Ala to pyruvate and NH3, inducible by L-Ala, D-Ala and 11 other D-amino acids. The enzyme catabolizes L-Ala, and thereby limits the amount of L-Ala available to alanine racemase for the synthesis of D-Ala
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
enzyme is involved in primary ammonium assimilation and the rapid formation of key metabolites pyruvate and NH3 from L-Ala and also in cell differentiation
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
physiological role in nitrogen metabolism in Streptomycetes
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
since the physiological environment of the organism has a neutral pH, it can be assumed that the enzyme catalyzes exclusively the formation of L-Ala
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
enzyme is required for utilization of alanine as a sole nitrogen source, enzyme is required for optimal growth under anaerobic conditions
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
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key enzyme in the metabolism of alanine, Ala is onyl fermented after lactate exhaustion and then at a slow rate
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-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
role in NH3 assimilation and alanine catabolism
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-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
role in NH3 assimilation and alanine catabolism
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
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no function in NH4+-assimilation but rather is required to supply the cells with the appropriate quantities of organic carbon when the organism grows at the expense of L-Ala as C-source and N-source
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-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
alternative route for ammonia assimilation when glutamine synthetase is inactivated
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
involved in taurine catabolism
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
enzyme formation is effectively induced by Ala
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
NH4+ assimilating enzyme
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-
?
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
Alkalihalophilus pseudofirmus
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-
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r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
Alkalihalophilus pseudofirmus ATCC BAA-2126
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-
-
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
Alkalihalophilus pseudofirmus JCM 17055
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-
-
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
Alkalihalophilus pseudofirmus OF4
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-
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r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
-
-
-
?
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
-
-
-
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
-
-
-
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
-
-
-
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
-
-
-
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
-
-
-
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
-
-
-
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
-
-
-
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
-
-
-
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
-
-
-
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
-
-
-
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
-
-
-
r
pyruvate + NH3 + NADH + H+
L-alanine + H2O + NAD+
-
-
-
r
additional information
?
-
-
the enzyme is required for normal sporulation
-
-
?
additional information
?
-
enzyme is involved in taurine metabolism
-
-
?
additional information
?
-
-
enzyme is involved in taurine metabolism
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-
?
additional information
?
-
-
circadian oscillations in alanine dehydrogenase
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-
?
additional information
?
-
-
circadian oscillations in alanine dehydrogenase
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-
?
additional information
?
-
-
enzyme Ald has both pyruvate and glyoxylate aminating activities
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-
?
additional information
?
-
-
enzyme Ald has both pyruvate and glyoxylate aminating activities
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-
?
additional information
?
-
-
strong induction immediately after deflection from aerobic growth suggests that alanine dehydrogenase may be required for the adaption from aerobic growth to anaerobic dormacy, the induction of alanine dehydrogenase may also support the maintenance of the NAD+ pool when oxygen as the terminal electron acceptor becomes limiting
-
-
?
additional information
?
-
the enzyme is induced by carboxylic acids (succinate, malate and pyruvate), although the best induer is alanine. The role of the enzyme may be to balance the alanine level for optimal functioning of bacteroid metabolism rather than to synthesize alanine as the sole product of N2 reduction
-
-
?
additional information
?
-
the enzyme is induced by carboxylic acids (succinate, malate and pyruvate), although the best induer is alanine. The role of the enzyme may be to balance the alanine level for optimal functioning of bacteroid metabolism rather than to synthesize alanine as the sole product of N2 reduction
-
-
?
additional information
?
-
-
important role in biosynthesis of erythromycin
-
-
?
additional information
?
-
the natural substrates of ALD enzymes for oxidative deamination and reductive amination reactions are believed to be L-alanine and pyruvate, respectively
-
-
-
additional information
?
-
-
the natural substrates of ALD enzymes for oxidative deamination and reductive amination reactions are believed to be L-alanine and pyruvate, respectively
-
-
-
additional information
?
-
the natural substrates of ALD enzymes for oxidative deamination and reductive amination reactions are believed to be L-alanine and pyruvate, respectively
-
-
-
additional information
?
-
-
the natural substrates of ALD enzymes for oxidative deamination and reductive amination reactions are believed to be L-alanine and pyruvate, respectively
-
-
-
additional information
?
-
the natural substrates of ALD enzymes for oxidative deamination and reductive amination reactions are believed to be L-alanine and pyruvate, respectively
-
-
-
additional information
?
-
the natural substrates of ALD enzymes for oxidative deamination and reductive amination reactions are believed to be L-alanine and pyruvate, respectively
-
-
-
additional information
?
-
-
enzyme activity during production phase of the antibiotic A 6599, enzyme induction by an excess of alanine or ammonia
-
-
?
additional information
?
-
-
substrate specifiicty, overview. The enzyme is also active with substrates DL-alanine, L-serine, L-isoleucine, L-threonine, and glycine, with L-serine giving the highest activity rate
-
-
?
