1.4.1.13: glutamate synthase (NADPH)

This is an abbreviated version!
For detailed information about glutamate synthase (NADPH), go to the full flat file.

Reaction

2 L-glutamate +

Synonyms

EC 2.6.1.53, EhNO1, EhNO2, gltA, gltB, GltB1, GltB2, gltD, GltS, glutamate synthetase (NADP), glutamine amide-2-oxoglutarate aminotransferase (oxidoreductase, NADP), glutamine-ketoglutaric aminotransferase, GOGAT, L-glutamate synthase, L-glutamate synthetase, L-glutamine:2-oxoglutarate aminotransferase, NADPH oxidizing, NADPH-dependent glutamate synthase, NADPH-GltS, NADPH-glutamate synthase, NADPH-GOGAT, NADPH-linked glutamate synthase, pGLTY1, pGLTY2, pGLTZ, PH0876, PH1873, synthase, glutamate (reduced nicotinamide adenine dinucleotide phosphate)

ECTree

     1 Oxidoreductases

         1.4 Acting on the CH-NH₂ group of donors

             1.4.1 With NAD⁺ or NADP⁺ as acceptor

                1.4.1.13 glutamate synthase (NADPH)

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Results	in table
1	Activating Compound
30170	AA Sequence
4	Application
1	CAS Registry Number
14	Cloned(Commentary)
97	Cofactor
3	Crystallization (Commentary)
4	General Information
15	General Stability
213	Inhibitors
53	Ki Value [mM]
83	KM Value [mM]
1	Localization
24	Metals/Ions
43	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
82	Organism
1	Oxidation Stability
8	Pathway
51	PDB ID
24	pH Optimum
4	pH Range
1	pH Stability
5	Protein Variants
24	Purification (Commentary)
7	Reaction
3	Reaction Type
69	Reference
2	Source Tissue
29	Specific Activity [micromol/min/mg]
5	Storage Stability
82	Substrates and Products (Substrate)
32	Subunits
79	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
1	Temperature Range [°C]
13	Temperature Stability [°C]
11	Turnover Number [1/s]

KI Value

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KI Value on EC 1.4.1.13 - glutamate synthase (NADPH)

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Ki VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.106

2',5'-ADP

Escherichia coli

-

-

391441

0.048

2',5'-diphosphoadenylic acid

Azospirillum brasilense

-

-

391467

2.1 - 17.2

2'-adenylic acid

3 entries

0.0028

2'-phosphoadenosine 5'-diphospho-5-beta-D-ribose

Azospirillum brasilense

-

-

391467

0.021 - 0.495

2'-phosphoadenosine-5'-diphospho-5'-beta-D-ribose

4 entries

0.0227 - 0.233

2'-phosphoadenosine-5'-diphosphoribose

2 entries

0.186

2'-phosphoadenylic acid

Azospirillum brasilense

-

-

391467

0.0024 - 0.128

3-Aminopyridine adenine dinucleotide phosphate

4 entries

0.0058

acetyl-NADP+

Azospirillum brasilense

-

-

391467

0.012

Cibacron blue 3GA

Geobacillus stearothermophilus

-

-

391451

0.011 - 0.056

D-glutamate

3 entries

0.02 - 0.76

DL-methionine DL-sulfoximine

3 entries

25 - 45

glutamate

2 entries

0.025

L-2-Amino-4-oxo-5-chloropentanoic acid

Escherichia coli

-

-

391457

1.05

L-methionine

Azospirillum brasilense

-

competitive inhibitor with respect to L-glutamine

391445

0.022

L-methionine sulfone

Geobacillus stearothermophilus

-

-

391451

0.48 - 5.5

methionine

3 entries

0.01 - 0.045

methionine sulfone

3 entries

0.02 - 1.13

NADP

7 entries

0.0059 - 0.037

NADP+

2 entries

0.8 - 20.6

oxalylglycine

3 entries

0.86

p-chloromercuribenzoate

Escherichia coli

-

-

391456

0.00023

thio-NADP+

Azospirillum brasilense

-

-

391467

additional information

additional information

3 entries

-

2.1

2'-adenylic acid

[Brevibacterium] flavum

-

competitive inhibitor with respect to NADPH

391447

17.1

2'-adenylic acid

[Brevibacterium] flavum

-

uncompetitive inhibitor with respect to glutamine

391447

17.2

2'-adenylic acid

[Brevibacterium] flavum

-

uncompetitive inhibitor with respect to alpha-keto-glutarate

391447

0.021

2'-phosphoadenosine-5'-diphospho-5'-beta-D-ribose

Azospirillum brasilense

-

for the NADPH:acceptor oxidoreductase activity of the beta subunit of the enzyme, substrate: NADPH, cosubstrate: ferricyanide

391463

0.08

2'-phosphoadenosine-5'-diphospho-5'-beta-D-ribose

Azospirillum brasilense

-

for the NADPH:acceptor oxidoreductase activity of the beta subunit of the enzyme, substrate: NADPH, cosubstrate: iodonitrotetrazolium

391463

0.18

2'-phosphoadenosine-5'-diphospho-5'-beta-D-ribose

Azospirillum brasilense

-

for the NADPH:acceptor oxidoreductase activity of the beta subunit of the enzyme, substrate: ferricyanide, cosubstrate: NADPH

391463

0.495

2'-phosphoadenosine-5'-diphospho-5'-beta-D-ribose

Azospirillum brasilense

-

for the NADPH:acceptor oxidoreductase activity of the beta subunit of the enzyme, substrate: iodonitrotetrazolium, cosubstrate: NADPH

391463

0.0227

2'-phosphoadenosine-5'-diphosphoribose

Azospirillum brasilense

-

inhibitor of the NADPH: iodonitrotetrazolium oxidoreductase reaction of wild type-beta subunit

391466

0.233

2'-phosphoadenosine-5'-diphosphoribose

Azospirillum brasilense

-

inhibitor of the NADPH: iodonitrotetrazolium oxidoreductase reaction of G298A-beta subunit

391466

0.0024

3-Aminopyridine adenine dinucleotide phosphate

Azospirillum brasilense

-

-

391467

0.0024

3-Aminopyridine adenine dinucleotide phosphate

Azospirillum brasilense

-

inhibitor of the holoenzyme, competitive with NADPH

391465

0.0112

3-Aminopyridine adenine dinucleotide phosphate

Azospirillum brasilense

-

inhibitor of the NADPH: iodonitrotetrazolium oxidoreductase reaction of wild type-beta subunit

391466

0.128

3-Aminopyridine adenine dinucleotide phosphate

Azospirillum brasilense

-

inhibitor of the NADPH: iodonitrotetrazolium oxidoreductase reaction of G298A-beta subunit

391466

0.011

D-glutamate

Azospirillum brasilense

-

good competitive inhibitor with respect to 2-oxoglutarate

391445

0.044

D-glutamate

Azospirillum brasilense

-

uncompetitive inhibitor with NADPH

391445

0.056

D-glutamate

Azospirillum brasilense

-

noncompetitive inhibitor with L-glutamine

391445

0.02

DL-methionine DL-sulfoximine

Gluconobacter oxydans

-

competitive inhibitor with respect to alpha-keto-glutarate

391448

0.14

DL-methionine DL-sulfoximine

Gluconobacter oxydans

-

competitive inhibitor with respect to glutamine

391448

0.76

DL-methionine DL-sulfoximine

Gluconobacter oxydans

-

noncompetitive inhibitor with respect to NADPH

391448

25

glutamate

[Brevibacterium] flavum

-

competitive inhibitor with respect to glutamine

391447

45

glutamate

[Brevibacterium] flavum

-

competitive inhibitor with respect to alpha-ketoglutarate

391447

0.48

methionine

Gluconobacter oxydans

-

competitive inhibitor with respect to alpha-keto-glutarate

391448

3

methionine

Gluconobacter oxydans

-

competitive inhibitor with respect to glutamine

391448

5.5

methionine

Gluconobacter oxydans

-

noncompetitive inhibitor with respect to NADPH

391448

0.01

methionine sulfone

[Brevibacterium] flavum

-

competitive inhibitor with respect to glutamine

391447

0.041

methionine sulfone

[Brevibacterium] flavum

-

uncompetitive inhibitor with respect to alpha-ketoglutarate

391447

0.045

methionine sulfone

[Brevibacterium] flavum

-

uncompetitive inhibitor with respect to NADPH

391447

0.02

NADP

Bacillus licheniformis

-

competitive inhibition with NADPH

391449

0.07

NADP

Gluconobacter oxydans

-

competitive inhibition with NADPH

391448

0.12

NADP

Gluconobacter oxydans

-

mixed-type inhibition with alpha-ketoglutarate

391448

0.25

NADP

[Brevibacterium] flavum

-

competitive inhibitor vs. NADPH

391447

0.3

NADP

Gluconobacter oxydans

-

uncompetitive inhibition with respect to glutamine

391448

0.69

NADP

[Brevibacterium] flavum

-

uncompetitive inhibitor vs. alpha-ketoglutarate

391447

1.13

NADP

[Brevibacterium] flavum

-

uncompetitive inhibitor vs. glutamine

391447

0.0059

NADP+

Azospirillum brasilense

-

-

391467

0.037

NADP+

Azospirillum brasilense

-

inhibitor of the NADPH: iodonitrotetrazolium oxidoreductase reaction of G298A-beta subunit

391466

0.8

oxalylglycine

[Brevibacterium] flavum

-

competitive inhibitor with respect to alpha-ketoglutarate

391447

19.3

oxalylglycine

[Brevibacterium] flavum

-

uncompetitive inhibitor with respect to glutamine

391447

20.6

oxalylglycine

[Brevibacterium] flavum

-

uncompetitive inhibitor with respect to NADP

391447

additional information

additional information

Escherichia coli

-

-

391442

-

additional information

additional information

Azospirillum brasilense

-

-

391465

-

additional information

additional information

Azospirillum brasilense

-

-

391467

-