1.4.1.14: glutamate synthase (NADH)
This is an abbreviated version!
For detailed information about glutamate synthase (NADH), go to the full flat file.
Reaction
Synonyms
gltA, GltA2, gltB, glutamate (reduced nicotinamide adenine dinucleotide) synthase, glutamate synthase, glutamate synthase (NADH), glutamate synthase (NADH-dependent), glutamate synthetase, glutamine 2-oxoglutarate aminotransferase, GOGAT, GOGAT1, GOGAT2, L-glutamate synthase (NADH), L-glutamate synthetase, NADH glutamate synthase, NADH-dependent glutamate synthase, NADH-dependent glutamine-2-oxoglutarate aminotransferase, NADH-GltS, NADH-glutamate synthase, NADH-GOGAT, NADH-GOGAT I, NADH-GOGAT II, NADH-GOGAT1, NADH-GOGAT2, NADH: GOGAT, Os01g0681900, Os05g0555600, synthase, glutamate (reduced nicotinamide adenine dinucleotide)
ECTree
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Inhibitors
Inhibitors on EC 1.4.1.14 - glutamate synthase (NADH)
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(2,5-dioxoimidazolidin-4-yl)urea
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activity of NADH-GOGAT I significantly decreases in the presence of 10 mM allantoine
2-hydroxyglutarate
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D- and L-isomer, most potent competitive inhibitor
3-acetylpyridine adenine dinucleotide
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competitive inhibitor with respect to NADH
allopurinol
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activity of NADH-GOGAT I significantly decreases in the presence of 2 mM allopurinol
glutamine
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activity of NADH-GOGAT I significantly decreases in the presence of 10 mM glutamine
L-2-Amino-4-oxo-5-chloropentanoate
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1 mM, 30 min, 0°C, pH 7.6, irreversible inhibition
L-homocysteine sulfonamide
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very potent transition state inhibitor, competitive to L-glutamine
O-diazoacetyl-L-serine
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1 mM, 30 min, 0°C, pH 7.6, irreversible inhibition
oxaloacetate
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weak inhibition, competitive with 2-oxoglutarate
p-hydroxymercuribenzoate
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complete inhibition at 0.1-1 mM, at 0.0005 mM 33% inhibition or 75% inhibition after preincubation in presence of glutamine and 2-oxoglutarate, substrates induce a conformation, which makes essential sulfhydryl groups more accessible to reagent
phenylalanine
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20 mM, complete inhibition
xanthine
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activity of NADH-GOGAT I significantly decreases in the presence of 10 mM xanthine
(2S)-2-amino-4-(S-methylsulfonimidoyl)butanoic acid
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potent irreversible inhibitor
6-diazo-5-oxo-L-norleucine
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0.1 mM, 30 min, 0°C, pH 7.6, irreversible inhibition
asparagine
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activity of NADH-GOGAT I significantly decreases in the presence of 10 mM asparagine
glycine
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48% inhibition at 10 mM, complete inhibition at 20 mM
L-Albizziin
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less inhibitory than L-homocysteine sulfonamide, methionine sulfone and ethionine sulfone
L-glutamate
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competitive with 2-oxoglutarate; glutamate binds 1.7times more tightly in the presence of NAD+
tryptophan
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29% inhibition at 10 mM, complete inhibition at 20 mM
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not inhibited by 1 mM cyanide or cyanate
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additional information
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not inhibited by alanine, glycine, serine, lysine, proline, cysteine, valine, leucine, isoleucine, threonine, phenylalanine, histidine, tryptophan, asparagine, arginine, UTP, ITP, GTP
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additional information
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not inhibited by 2,2-dipyridyl or N-ethylmaleimide
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additional information
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the presence of asparagine, glutamine, xanthine, allantoin, allopurinol in the nutrient solution does not affect the expression of NADH-GOGAT-II in the nodules
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additional information
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cumulative inhibition by combinations of amino acids and nucleotides, cumulative feedback inhibition
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additional information
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not inhibited by the 20 common amino acids at a concentration of 20 mM
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additional information
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enzyme activity declines significantly between 42-68% and 9-42% relative water content in leaves
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