1.4.1.21: aspartate dehydrogenase

This is an abbreviated version!
For detailed information about aspartate dehydrogenase, go to the full flat file.

Reaction

Synonyms

AspDH, L-aspartate dehydrogenase, L-aspartate:NAD(P)+ oxidoreductase (deaminating), L-aspDH, NAD-dependent aspartate dehydrogenase, NADH2-dependent aspartate dehydrogenase, NADP+-dependent aspartate dehydrogenase, nadX

ECTree

     1 Oxidoreductases

         1.4 Acting on the CH-NH₂ group of donors

             1.4.1 With NAD⁺ or NADP⁺ as acceptor

                1.4.1.21 aspartate dehydrogenase

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Results	in table
1	Activating Compound
4875	AA Sequence
19	Application
1	CAS Registry Number
14	Cloned(Commentary)
58	Cofactor
2	Crystallization (Commentary)
31	General Information
2	General Stability
4	Inhibitors
26	kcat/KM [mM/s]
2	Ki Value [mM]
74	KM Value [mM]
14	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
54	Organism
4	Pathway
2	PDB ID
19	pH Optimum
2	pH Range
4	pH Stability
4	Protein Variants
9	Purification (Commentary)
3	Reaction
3	Reaction Type
25	Reference
20	Specific Activity [micromol/min/mg]
1	Storage Stability
110	Substrates and Products (Substrate)
29	Subunits
44	Synonyms
1	Systematic Name
13	Temperature Optimum [°C]
3	Temperature Range [°C]
22	Temperature Stability [°C]
34	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 1.4.1.21 - aspartate dehydrogenase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

L-aspartate + H2O + NAD(P)+

oxaloacetate + NH3 + NAD(P)H + H+

13 entries

L-aspartate + NAD(P)+

oxaloacetate + NH4+ + NAD(P)H

Thermotoga maritima

Q9X1X6

-

654027

-

-

?

L-aspartate + NADP+ + H2O

oxaloacetate + NH4+ + NADPH

Klebsiella pneumoniae

-

-

652990

-

652990

?

oxaloacetate + NAD(P)H + NH4+

L-aspartate + NAD(P)+

Thermotoga maritima

Q9X1X6

-

654027

-

-

?

oxaloacetate + NH4+ + NADH

L-aspartate + NAD+ + H2O

2 entries

additional information

?

-

2 entries

L-aspartate + H2O + NAD(P)+

oxaloacetate + NH3 + NAD(P)H + H+

Archaeoglobus fulgidus

-

-

724068

-

-

r

L-aspartate + H2O + NAD(P)+

oxaloacetate + NH3 + NAD(P)H + H+

Bradyrhizobium japonicum

-

-

723988

-

-

r

L-aspartate + H2O + NAD(P)+

oxaloacetate + NH3 + NAD(P)H + H+

Cupriavidus necator

-

-

724068

-

-

r

L-aspartate + H2O + NAD(P)+

oxaloacetate + NH3 + NAD(P)H + H+

Cupriavidus necator

Q46VA0

-

724591

-

-

r

L-aspartate + H2O + NAD(P)+

oxaloacetate + NH3 + NAD(P)H + H+

Cupriavidus necator JMP 134-1

-

-

724068

-

-

r

L-aspartate + H2O + NAD(P)+

oxaloacetate + NH3 + NAD(P)H + H+

Cupriavidus necator JMP 134-1

Q46VA0

-

724591

-

-

r

L-aspartate + H2O + NAD(P)+

oxaloacetate + NH3 + NAD(P)H + H+

Klebsiella pneumoniae

-

-

724068

-

-

r

L-aspartate + H2O + NAD(P)+

oxaloacetate + NH3 + NAD(P)H + H+

Klebsiella pneumoniae IFO 13541

-

-

724068

-

-

r

L-aspartate + H2O + NAD(P)+

oxaloacetate + NH3 + NAD(P)H + H+

Klebsiella pneumoniae MGH 78578

-

-

724068

-

-

r

L-aspartate + H2O + NAD(P)+

oxaloacetate + NH3 + NAD(P)H + H+

Pseudomonas aeruginosa

-

-

724055

-

-

r

L-aspartate + H2O + NAD(P)+

oxaloacetate + NH3 + NAD(P)H + H+

Pseudomonas aeruginosa

Q9HYA4

-

724068

-

-

r

L-aspartate + H2O + NAD(P)+

oxaloacetate + NH3 + NAD(P)H + H+

Rhodopseudomonas palustris

-

-

723988

-

-

r

L-aspartate + H2O + NAD(P)+

oxaloacetate + NH3 + NAD(P)H + H+

Thermotoga maritima

-

-

724068, 724614

-

-

r

oxaloacetate + NH4+ + NADH

L-aspartate + NAD+ + H2O

Bradyrhizobium lupini

-

biosynthesis of aspartate

653561

-

653561

?

oxaloacetate + NH4+ + NADH

L-aspartate + NAD+ + H2O

Bradyrhizobium lupini 359a

-

biosynthesis of aspartate

653561

-

653561

?

additional information

?

-

Cupriavidus necator

Q46VA0

the wild-type strain synthesizes 3-hydroxy-polybutyrate from fructose or L-Asp, while the enzyme knockout mutant strain does not

724591

-

-

?

additional information

?

-

Cupriavidus necator JMP 134-1

Q46VA0

the wild-type strain synthesizes 3-hydroxy-polybutyrate from fructose or L-Asp, while the enzyme knockout mutant strain does not

724591

-

-

?