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1.4.1.9: leucine dehydrogenase

This is an abbreviated version!
For detailed information about leucine dehydrogenase, go to the full flat file.

Word Map on EC 1.4.1.9

Reaction

L-leucine
+
H2O
+
NAD+
=
4-methyl-2-oxopentanoate
+
NH3
+
NADH
+
H+

Synonyms

BCD, dehydrogenase, leucine, L-leucine dehydrogenase, L-leucine:NAD+ oxidoreductase, deaminating, LeuDH

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.1 With NAD+ or NADP+ as acceptor
                1.4.1.9 leucine dehydrogenase

KI Value

KI Value on EC 1.4.1.9 - leucine dehydrogenase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
140
4-methyl-2-pentanone
-
wild-type enzyme
20 - 33
4-methylpentanoate
9.4
D-2-aminobutanoate
-
inhibition of deamination of D-Leu
7.9
D-alloisoleucine
-
inhibition of deamination of D-Leu
2.2
D-Leu
-
inhibition of deamination of D-Leu
52.6
D-norleucine
-
inhibition of deamination of D-Leu
3
D-Norvaline
-
inhibition of deamination of D-Leu
10.8
D-Val
-
inhibition of deamination of D-Leu
1
L-Leu
-
competitive inhibition of the reductive amination of 4-methylthio-2-oxobutanoate