1.4.1.B4: carboxynorspermidine dehydrogenase

This is an abbreviated version!
For detailed information about carboxynorspermidine dehydrogenase, go to the full flat file.

Reaction

Synonyms

C-NSPD synthase, CANSDH, carboxynorspermidine synthase

ECTree

1 Oxidoreductases

1.4 Acting on the CH-NH₂ group of donors

1.4.1 With NAD⁺ or NADP⁺ as acceptor

1.4.1.B4 carboxynorspermidine dehydrogenase

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Results	in table
2	Activating Compound
1	AA Sequence
1	CAS Registry Number
3	Cofactor
4	General Information
1	General Stability
8	Inhibitors
4	KM Value [mM]
1	Metals/Ions
2	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
2	Organism
1	pH Optimum
1	pH Range
1	pH Stability
1	pI Value
1	Protein Variants
1	Purification (Commentary)
3	Reaction
2	Reference
5	Specific Activity [micromol/min/mg]
1	Storage Stability
9	Substrates and Products (Substrate)
2	Subunits
5	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]

Inhibitors

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Inhibitors on EC 1.4.1.B4 - carboxynorspermidine dehydrogenase

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1,2-diaminopropane

Vibrio alginolyticus

10 mM, causes 10-20% inhibition of carboxynorspermidine formation

712623

cadaverine

Vibrio alginolyticus

10 mM, causes 10-20% inhibition of carboxynorspermidine formation

712623

ethylenediamine

Vibrio alginolyticus

10 mM, causes 10-20% inhibition of carboxynorspermidine formation

712623

ethylmaleimide

Vibrio alginolyticus

5 mM, in presence of 20 mM, 83% inhibition

712623

iodoacetamide

Vibrio alginolyticus

5 mM, in presence of 20 mM, 24% inhibition

NADP+

5 mM, 51% inhibition

norspermidine

10 mM, 10% inhibition

712623

additional information

Vibrio alginolyticus

no inhibitory effect of NAD+, ATP, and spermidine at 5 or 10 mM. No effect of 1 mM Na+ or K+. No evidence for inhibitory effect of metal cations such as Ca2+, Mg2+, Fe3+, Fe2+, Cu+, Cu2+, Mn2+, and Zn2+. EDTA, 1 mM no inhibition

712623