1.4.3.1: D-aspartate oxidase
This is an abbreviated version!
For detailed information about D-aspartate oxidase, go to the full flat file.
Word Map on EC 1.4.3.1
-
1.4.3.1
-
d-amino
-
n-methyl-d-aspartate
-
nmda
-
d-serine
-
d-glutamate
-
octopus
-
nmdar-dependent
-
d-alanine
-
prepulse
-
humicola
-
d-amino-acid
-
d-ser
-
d-glu
-
drug development
-
molecular biology
-
medicine
- 1.4.3.1
-
d-amino
- n-methyl-d-aspartate
- nmda
- d-serine
- d-glutamate
- octopus
-
nmdar-dependent
- d-alanine
-
prepulse
- humicola
-
d-amino-acid
- d-ser
- d-glu
- drug development
- molecular biology
- medicine
Reaction
Synonyms
aspartic oxidase, C47A10.5 gene product, C47Ap, ChDASPO, ChDDO, D-Asp oxidase, D-aspartic oxidase, D-AspO, DAO, DASOX, DASPO, DDO, DDO-1, DDO-2, DDO-3, DDO1, DDO3, F18E3.7a gene product, F18Ep
ECTree
1.4.3.1 D-aspartate oxidaseAdvanced search results
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Reference on EC 1.4.3.1 - D-aspartate oxidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sacchi, S.; Lorenzi, S.; Molla, G.; Pilone, M.S.; Rossetti, C.; Pollegioni, L.
Engineering the substrate specificity of D-amino-acid oxidase
J. Biol. Chem.
277
27510-27516
2002
Bos taurus
Zaar, K.; Kost, H.P.; Schad, A.; Volkl, A.; Baumgart, E.; Fahimi, H.D.
Cellular and subcellular distribution of D-aspartate oxidase in human and rat brain
J. Comp. Neurol.
450
272-282
2002
Bos taurus, Homo sapiens, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Negri, A.; Tedeschi, G.; Ceciliani, F.; Ronchi, S.
Purification of beef kidney D-aspartate oxidase overexpressed in Escherichia coli and characterization of its redox potentials and oxidative activity towards agonists and antagonists of excitatory amino acid receptors
Biochim. Biophys. Acta
1431
212-222
1999
Bos taurus
Tedeschi, G.; Negri, A.; Bernardini, G.; Oungre, E.; Ceciliani, F.; Ronchi, S.
D-Aspartate oxidase is present in ovaries, eggs and embryos but not in testis of Xenopus laevis
Comp. Biochem. Physiol. B
124
489-494
1999
Bos taurus, Xenopus laevis
Amery, L.; Brees, C.; Baes, M.; Setoyama, C.; Miura, R.; Mannaerts, G.P.; Van Veldhoven, P.P.
C-terminal tripeptide Ser-Asn-Leu (SNL) of human D-aspartate oxidase is a functional peroxisome-targeting signal
Biochem. J.
336
367-371
1998
Homo sapiens
Kera, Y.; Hasegawa, S.; Watanabe, T.; Segawa, H.; Yamada, R.H.
D-Aspartate oxidase and free acidic D-amino acids in fish tissues
Comp. Biochem. Physiol. B
119
95-100
1998
Carassius langsdorfii, Cyprinus carpio, Oncorhynchus mykiss, Pagrus major, Seriola quinqueradiata
-
Simonic, T.; Duga, S.; Negri, A.; Tedeschi, G.; Malcovati, M.; Tenchini, M.L.; Ronchi, S.
cDNA cloning and expression of the flavoprotein D-aspartate oxidase from bovine kidney cortex
Biochem. J.
322
729-735
1997
Bos taurus
Setoyama, C.; Miura, R.
Structural and functional characterization of the human brain D-aspartate oxidase
J. Biochem.
121
798-803
1997
Homo sapiens
Yamada, R.h.; Ujiie, H.; Kera, Y.; Nakase, T.; Kitagawa, K.; Imasaka, T.; Arimoto, K.; Takahashi, M.; Matsumura, Y.
Purification and properties of D-aspartate oxidase from Cryptococcus humicolus UJ1
Biochim. Biophys. Acta
1294
153-158
1996
Vanrija humicola, Vanrija humicola UJ1
Tedeschi, G.; Negri, A.; Ceciliani, F.; Ronchi, S.; Vetere, A.; D'Aniello, G.; D'Aniello, A.
Properties of the flavoenzyme D-aspartate oxidase from Octopus vulgaris
Biochim. Biophys. Acta
1207
217-222
1994
Octopus vulgaris
Wakayama, M.; Nakashima, S.; Sakai, K.; Moriguchi, M.
Isolation, enzyme production and characterization of D-aspartate oxidase from Fusarium sacchari var. elongatum Y-105
J. Ferment. Bioeng.
78
377-379
1994
Fusarium sacchari
-
D'Aniello, A.; D'Onofrio, G.; Pischetola, M.; D'Aniello, G.; Vetere, A.; Petrucelli, L.; Fisher, G.H.
Biological role of D-amino acid oxidase and D-aspartate oxidase. Effects of D-amino acids
J. Biol. Chem.
268
26941-26949
1993
Mus musculus, Octopus vulgaris, Rattus norvegicus
D'Aniello, A.; Vetere, A.; Petrucelli, L.
Further study on the specificity of D-amino acid oxidase and of D-aspartate oxidase and time course for complete oxidation of D-amino acids
Comp. Biochem. Physiol. B
105
731-734
1993
Bos taurus, Octopus vulgaris
Tedeschi, G.; Negri, A.; Ceciliani, F.; Biondi, P.A.; Secchi, C.; Ronchi, S.
Chemical modification of functional arginyl residues in beef kidney D-aspartate oxidase
Eur. J. Biochem.
205
127-132
1992
Bos taurus
Negri, A.; Tedeschi, G.; Ceciliani, F.; Simonic, T.
Structural studies of beef kidney D-aspartate oxidase
Flavins and Flavoproteins (Proc. Int. Symp. , 10th, Meeting Date 1990, Curti, B. , Ronchi S. , Zanetti, G. , eds. ) de Gruyter, Berlin, New York
179-187
1990
Bos taurus
-
Tedeschi, G.; Negri, A.; Biondi, P.A.; Secchi, C.; Ronchi, S.
Modification of substrate specificity of D-aspartate oxidase chemically modified phenylglyoxal
Flavins and Flavoproteins (Proc. Int. Symp. , 10th, Meeting Date 1990, Curti, B. , Ronchi S. , Zanetti, G. , eds. ) de Gruyter, Berlin, New York
189-192
1990
Bos taurus
-
Negri, A.; Massey, V.; Williams, C.H.; Schopfer, L.M.
The kinetic mechanism of beef kidney D-aspartate oxidase
J. Biol. Chem.
263
13557-13563
1988
Bos taurus
Negri, A.; Massey, V.; Williams, C.H.
D-Aspartate oxidase from beef kidney. Purification and properties
J. Biol. Chem.
262
10026-10034
1987
Bos taurus
Burns, C.L.; Main, D.E.; Buckthal, D.J.; Hamilton, G.A.
Thiazolidine-2-carboxylate derivatives formed from glyoxylate and L-cysteine or L-cysteinylglycine as possible physiological substrates for D-aspartate oxidase
Biochem. Biophys. Res. Commun.
125
1039-1045
1984
Bos taurus
Nasu, S.; Wicks, F.D.; Gholson, R.K.
The mammalian enzyme which replaces B protein of E.coli quinolinate synthetase is D-aspartate oxidase
Biochim. Biophys. Acta
704
240-252
1982
Bos taurus
Rinaldi, A.; Pellegrini, M.; Crifo, C.; de Marco, C.
Oxidation of meso-diaminosuccinic acid, a possible natural substrate for D-aspartate oxidase
Eur. J. Biochem.
117
635-638
1981
Bos taurus
Jaroszewicz, L.
D-Asparatate oxidase in the thyroid gland
Enzyme
20
80-89
1975
Sus scrofa
Dixon, M.; Kenworthy, P.
D-aspartate oxidase of kidney
Biochim. Biophys. Acta
146
54-76
1967
Oryctolagus cuniculus
Still, J.L.; Sperling, E.
On the prosthetic group of the D-aspartic oxidase
J. Biol. Chem.
182
585-589
1950
Oryctolagus cuniculus, Ovis aries, Sus scrofa
-
Takahashi, S.; Takahashi, T.; Kera, Y.; Matsunaga, R.; Shibuya, H.; Yamada, R.H.
Cloning and expression in Escherichia coli of the D-aspartate oxidase gene from the yeast Cryptococcus humicola and characterization of the recombinant enzyme
J. Biochem.
135
533-540
2004
Vanrija humicola (Q75WF1), Vanrija humicola
Sarower, M.G.; Matsui, T.; Abe, H.
Distribution and characteristics of D-amino acid and D-aspartate oxidases in fish tissues
J. Exp. Zool. A
295
151-159
2003
Cyprinus carpio, Lateolabrax japonicus, Oncorhynchus mykiss, Oncorhynchus keta, Pagrus major, Paralichthys olivaceus, Scomber japonicus, Sardinops melanostictus, Trachurus japonicus, Oncorhynchus masou, Plecoglossus altivelis, Evynnis tumifrons, Cololabis saira, Thamnaconus tessellatus, Verasper variegatus, Pseudopleuronectes yokohamae, Chaunax fimbriatus
Sarower, M.G.; Matsui, T.; Abe, H.
Distribution and substrate specificity of D-amino acid and D-aspartate oxidases in marine invertebrates
Science Asia
30
335-340
2004
Turbo cornutus, Meretrix lusoria, Mytilus galloprovincialis, Octopus vulgaris, Mizuhopecten yessoensis, Penaeus japonicus, Todarodes pacificus, Procambarus clarkii
-
Katane, M.; Seida, Y.; Sekine, M.; Furuchi, T.; Homma, H.
Caenorhabditis elegans has two genes encoding functional D-aspartate oxidases
FEBS J.
274
137-149
2007
Caenorhabditis elegans
Takahashi, S.; Kakuichi, T.; Fujii, K.; Kera, Y.; Yamada, R.
Physiological role of D-aspartate oxidase in the assimilation and detoxification of D-aspartate in the yeast Cryptococcus humicola
Yeast
22
1203-1212
2005
Vanrija humicola
Katane, M.; Furuchi, T.; Sekine, M.; Homma, H.
Molecular cloning of a cDNA encoding mouse D-aspartate oxidase and functional characterization of its recombinant proteins by site-directed mutagenesis
Amino Acids
32
69-78
2007
Mus musculus
Katane, M.; Hanai, T.; Furuchi, T.; Sekine, M.; Homma, H.
Hyperactive mutants of mouse D-aspartate oxidase: mutagenesis of the active site residue serine 308
Amino Acids
35
75-82
2008
Mus musculus (Q0E9Q7), Mus musculus
Huang, A.S.; Lee, D.A.; Blackshaw, S.
D-Aspartate and D-aspartate oxidase show selective and developmentally dynamic localization in mouse retina
Exp. Eye Res.
86
704-709
2008
Mus musculus
Yamamoto, A.; Tanaka, H.; Ishida, T.; Horiike, K.
Functional and structural characterization of D-aspartate oxidase from porcine kidney: non-Michaelis kinetics due to substrate activation
J. Biochem.
141
363-376
2007
Sus scrofa (A3KCL7), Sus scrofa
Katane, M.; Saitoh, Y.; Hanai, T.; Sekine, M.; Furuchi, T.; Koyama, N.; Nakagome, I.; Tomoda, H.; Hirono, S.; Homma, H.
Thiolactomycin inhibits D-aspartate oxidase: a novel approach to probing the active site environment
Biochimie
92
1371-1378
2010
Homo sapiens, Mus musculus
Katane, M.; Saitoh, Y.; Seida, Y.; Sekine, M.; Furuchi, T.; Homma, H.
Comparative characterization of three D-aspartate oxidases and one D-amino acid oxidase from Caenorhabditis elegans
Chem. Biodivers.
7
1424-1434
2010
Caenorhabditis elegans
Katane, M.; Homma, H.
D-aspartate oxidase: The sole catabolic enzyme acting on free D-aspartate in mammals
Chem. Biodivers.
7
1435-1449
2010
Bos taurus, Caenorhabditis elegans, Homo sapiens, Mus musculus, Ovis aries, Rattus norvegicus, Sus scrofa, Vanrija humicola
Burrone, L.; Di Giovanni, M.; Di Fiore, M.M.; Baccari, G.C.; Santillo, A.
Effects of D-aspartate treatment on D-aspartate oxidase, superoxide dismutase, and caspase 3 activities in frog (Rana esculenta) tissues
Chem. Biodivers.
7
1459-1466
2010
Pelophylax lessonae
Topo, E.; Fisher, G.; Sorricelli, A.; Errico, F.; Usiello, A.; DAniello, A.
Thyroid hormones and D-aspartic acid, D-aspartate oxidase, D-aspartate racemase, H2O2, and ROS in rats and mice
Chem. Biodivers.
7
1467-1478
2010
Mus musculus, Rattus norvegicus
di Giovanni, M.; Burrone, L.; Baccari, G.; Topo, E.; Santillo, A.
Distribution of free D-aspartic acid and D-aspartate oxidase in frog Rana esculenta tissues
J. Exp. Zool.
313 A
137-143
2010
Pelophylax lessonae
Takahashi, S.; Matsumoto, S.; Maruyama, K.; Wakaizumi, A.; Abe, K.; Kera, Y.; Yamada, R.
An active-site mutation enhances the catalytic activity of the yeast Cryptococcus humicola D-aspartate oxidase
J. Mol. Catal. B
61
235-240
2009
Vanrija humicola (Q75WF1)
-
Yamamoto, A.; Tanaka, H.; Ishida, T.; Horiike, K.
D-aspartate oxidase localisation in pituitary and pineal glands of the female pig
J. Neuroendocrinol.
22
1165-1172
2010
Sus scrofa
Senda, M.; Yamamoto, A.; Tanaka, H.; Ishida, T.; Horiike, K.; Senda, T.
Crystallization and preliminary crystallographic analysis of D-aspartate oxidase from porcine kidney
Acta Crystallogr. Sect. F
68
644-646
2012
Sus scrofa
Kato, S.; Ikuta, T.; Hemmi, H.; Takahashi, S.; Kera, Y.; Yoshimura, T.
Enzymatic assay for D-aspartic acid using D-aspartate oxidase and oxaloacetate decarboxylase
Biosci. Biotechnol. Biochem.
76
2150-2152
2012
Vanrija humicola
Saitoh, Y.; Katane, M.; Kawata, T.; Maeda, K.; Sekine, M.; Furuchi, T.; Kobuna, H.; Sakamoto, T.; Inoue, T.; Arai, H.; Nakagawa, Y.; Homma, H.
Spatiotemporal localization of D-amino acid oxidase and D-aspartate oxidases during development in Caenorhabditis elegans
Mol. Cell. Biol.
32
1967-1983
2012
Caenorhabditis elegans, Caenorhabditis elegans (O45307), Caenorhabditis elegans (Q19564), Caenorhabditis elegans N2, Caenorhabditis elegans N2 (O45307), Caenorhabditis elegans N2 (Q19564)
Takahashi, S.; Furukawara, M.; Omae, K.; Tadokoro, N.; Saito, Y.; Abe, K.; Kera, Y.
A highly stable d-amino acid oxidase of the thermophilic bacterium Rubrobacter xylanophilus
Appl. Environ. Microbiol.
80
7219-7229
2014
no activity in Rubrobacter xylanophilus
Katane, M.; Kawata, T.; Nakayama, K.; Saitoh, Y.; Kaneko, Y.; Matsuda, S.; Saitoh, Y.; Miyamoto, T.; Sekine, M.; Homma, H.
Characterization of the enzymatic and structural properties of human D-aspartate oxidase and comparison with those of the rat and mouse enzymes
Biol. Pharm. Bull.
38
298-305
2015
Rattus norvegicus (D3ZDM7), Mus musculus (Q0E9Q7), Mus musculus, Homo sapiens (Q99489), Homo sapiens
Florio, E.; Keller, S.; Coretti, L.; Affinito, O.; Scala, G.; Errico, F.; Fico, A.; Boscia, F.; Sisalli, M.J.; Reccia, M.G.; Miele, G.; Monticelli, A.; Scorziello, A.; Lembo, F.; Colucci-DAmato, L.; Minchiotti, G.; Avvedimento, V.E.; Usiello, A.; Cocozza, S.; Chiariotti, L.
Tracking the evolution of epialleles during neural differentiation and brain development D-Aspartate oxidase as a model gene
Epigenetics
12
41-54
2017
Mus musculus (Q0E9Q7)
Takahashi, S.; Shimada, K.; Nozawa, S.; Goto, M.; Abe, K.; Kera, Y.
Possible role of a histidine residue in the substrate specificity of yeast D-aspartate oxidase
J. Biochem.
159
371-378
2016
Vanrija humicola (Q75WF1), Vanrija humicola
Katane, M.; Yamada, S.; Kawaguchi, G.; Chinen, M.; Matsumura, M.; Ando, T.; Doi, I.; Nakayama, K.; Kaneko, Y.; Matsuda, S.; Saitoh, Y.; Miyamoto, T.; Sekine, M.; Yamaotsu, N.; Hirono, S.; Homma, H.
Identification of novel D-aspartate oxidase inhibitors by in silico screening and their functional and structural characterization in vitro
J. Med. Chem.
58
7328-7340
2015
Homo sapiens (Q99489), Homo sapiens
Punzo, D.; Errico, F.; Cristino, L.; Sacchi, S.; Keller, S.; Belardo, C.; Luongo, L.; Nuzzo, T.; Imperatore, R.; Florio, E.; De Novellis, V.; Affinito, O.; Migliarini, S.; Maddaloni, G.; Sisalli, M.J.; Pasqualetti, M.; Pollegioni, L.; Maione, S.; Chiariotti, L.; Usiello, A.
Age-related changes in D-aspartate oxidase promoter methylation control extracellular D-aspartate levels and prevent precocious cell death during brain aging
J. Neurosci.
36
3064-3078
2016
Mus musculus (Q0E9Q7), Mus musculus
Han, H.; Miyoshi, Y.; Koga, R.; Mita, M.; Konno, R.; Hamase, K.
Changes in D-aspartic acid and D-glutamic acid levels in the tissues and physiological fluids of mice with various D-aspartate oxidase activities
J. Pharm. Biomed. Anal.
116
47-52
2015
Mus musculus
Cristino, L.; Luongo, L.; Squillace, M.; Paolone, G.; Mango, D.; Piccinin, S.; Zianni, E.; Imperatore, R.; Iannotta, M.; Longo, F.; Errico, F.; Vescovi, A.L.; Morari, M.; Maione, S.; Gardoni, F.; Nistico, R.; Usiello, A.
D-aspartate oxidase influences glutamatergic system homeostasis in mammalian brain
Neurobiol. Aging
36
1890-1902
2015
Mus musculus (Q0E9Q7)
Sacchi, S.; Novellis, V.; Paolone, G.; Nuzzo, T.; Iannotta, M.; Belardo, C.; Squillace, M.; Bolognesi, P.; Rosini, E.; Motta, Z.; Frassineti, M.; Bertolino, A.; Pollegioni, L.; Morari, M.; Maione, S.; Errico, F.; Usiello, A.
Olanzapine, but not clozapine, increases glutamate release in the prefrontal cortex of freely moving mice by inhibiting D-aspartate oxidase activity
Sci. Rep.
7
46288
2017
Mus musculus (Q0E9Q7), Homo sapiens (Q99489), Homo sapiens
Takahashi, S.; Osugi, K.; Shimekake, Y.; Shinbo, A.; Abe, K.; Kera, Y.
Characterization and improvement of substrate-binding affinity of D-aspartate oxidase of the thermophilic fungus Thermomyces dupontii
Appl. Microbiol. Biotechnol.
103
4053-4064
2019
Thermomyces dupontii, Thermomyces dupontii NBRC 30541
Katane, M.; Kanazawa, R.; Kobayashi, R.; Oishi, M.; Nakayama, K.; Saitoh, Y.; Miyamoto, T.; Sekine, M.; Homma, H.
Structure-function relationships in human D-aspartate oxidase characterisation of variants corresponding to known single nucleotide polymorphisms
Biochim. Biophys. Acta
1865
1129-1140
2017
Homo sapiens (C9K4X7), Homo sapiens
Katane, M.; Kuwabara, H.; Nakayama, K.; Saitoh, Y.; Miyamoto, T.; Sekine, M.; Homma, H.
Rat D-aspartate oxidase is more similar to the human enzyme than the mouse enzyme
Biochim. Biophys. Acta
1866
806-812
2018
Rattus norvegicus (D3ZDM7), Mus musculus (Q0E9Q7), Mus musculus
Katane, M.; Kuwabara, H.; Nakayama, K.; Saitoh, Y.; Miyamoto, T.; Sekine, M.; Homma, H.
Biochemical characterization of d-aspartate oxidase from Caenorhabditis elegans its potential use in the determination of free D-glutamate in biological samples
Biochim. Biophys. Acta
1868
140442
2020
Caenorhabditis elegans (O45307), Caenorhabditis elegans
Puggioni, V.; Savinelli, A.; Miceli, M.; Molla, G.; Pollegioni, L.; Sacchi, S.
Biochemical characterization of mouse D-aspartate oxidase
Biochim. Biophys. Acta
1868
140472
2020
Mus musculus (Q0E9Q7), Mus musculus
Molla, G.; Chaves-Sanjuan, A.; Savinelli, A.; Nardini, M.; Pollegioni, L.
Structure and kinetic properties of human D-aspartate oxidase, the enzyme-controlling D-aspartate levels in brain
FASEB J.
34
1182-1197
2020
Homo sapiens (Q99489), Homo sapiens
Saitoh, Y.; Katane, M.; Miyamoto, T.; Sekine, M.; Sakamoto, T.; Imai, H.; Homma, H.
Secreted D-aspartate oxidase functions in C. elegans reproduction and development
FEBS J.
286
124-138
2019
Caenorhabditis elegans (O01739), Caenorhabditis elegans
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