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drug target
the enzyme is a promising therapeutic target for the progression of cancer and fibrosis
evolution
J9NZK5
the protein is very well conserved throughout the course of evolution
malfunction
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association between enzyme polymorphisms and oral submucous fibrosis in older male areca chewers
malfunction
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excess collagen deposition in ovarian stroma in polycystic ovary syndrome involves increased enzyme activity due to stimulation by advenced glycation end products
malfunction
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reduced enzyme expression is involved in the vitreous of proliferative diabetic retinopathy, PDR, and rhegmatogenous retinal detachment, RRD
malfunction
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the enzyme regulates collagen cross-linking, which is increased in heart failure patients compared with healthy hearts. Enzyme overexpression is associated with enhanced collagen cross-linking in the failing human heart. Ability of torasemide to correct both lysyl oxidase overexpression and enhanced collagen cross-linking
malfunction
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enzyme inhibition stops early mechanical development of tendon constructs and leads to irregularly shaped collagen fibrils
malfunction
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inhibition of lysyl oxidase activity stabilizes oncogenic stress-induced senescence, delays tumorigenesis, and increases survival
metabolism
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the enzyme is linked to crosslinking of elastin and collagen, it enhances tropoelastin crosslinking into matrix structures and elastin matrix yield, overview
metabolism
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the enzyme is linked to crosslinking of elastin and collagen, it enhances tropoelastin crosslinking into matrix structures and elastin synthesis and matrix yield, overview
metabolism
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by deacetylating and deacetyliminating Stat3 on multiple acetyl-lysine sites in nuclei, the enzyme regulates Stat3 dimerization and transcriptional activity. Furthermore, CD4+ T cell differentiation in inflammatory responses is regulated by the enzyme-Stat3 signaling pathway
metabolism
co-overexpression of specific protein 1 (SP1) and LOXL2 significantly correlates with poor prognosis in patients with pancreatic cancer
metabolism
the enzyme catalyzes cross-linking of collagen and elastin in the extracellular matrix
metabolism
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the enzyme catalyzes cross-linking of collagen and elastin in the extracellular matrix
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physiological function
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LOX cross-links the side chain of collagen and elastin and thereby contributes to extracellular matrix integrity
physiological function
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LOX is a copper-activated enzyme critical for collagen cross-linking and organization of extracellular matrix
physiological function
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lysyl oxidase acts as both a matrix modifying enzyme and an oncogene suppressor
physiological function
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lysyl oxidase is a copper-dependent amine oxidase that catalyzes the crosslinking of collagens and elastin, and is thus critical for the stability of the extracellular matrix. LOX mediates suppression of MCP-1, one of the highly upregulated chemokines, and subsequent inflammatory responses, overview
physiological function
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lysyl oxidases play a critical role in matrix assembly by crosslinking elastin and collagen monomers into fibers
physiological function
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overall survival rates of the patients with esophageal squamous cell carcinoma with high LOX expression are significantly lower than those of the patients with esophageal squamous cell carcinoma with low LOX expression
physiological function
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role for lysyl oxidase-like, LOXL1, in adult elastin synthesis and a role for its isoform, lysyl oxidase, LOX, in the synthesis of both collagens and elastin during development. Specific roles for LOX and LOXL1 in the synthesis and remodeling of elastic and collagen fibers, overview
physiological function
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the enzyme binds to mature TGF-beta1 and enzymatically regulates its signaling in bone and plays an important role in bone maintenance and remodeling
physiological function
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the enzyme is involved n collagen synthesis. It catalyzes the collagen and elastin cross-linking and plays an essential role in coordinating the control of ovarian extracellular matrix during ovarian follicle development, overview
physiological function
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the enzyme regulates collagen cross-linking
physiological function
the extracellular matrix remodeling enzyme has a role in promoting breast cancer cell motility and invasiveness. LOX activity is required during extravasation and/or initial tissue colonization by circulating MDA-MB-231 cells, metastasis model and drug administration study in mice, overview
physiological function
LOX is the principal enzyme involved in crosslinking of collagen. Nuclear lysyl oxidase probably regulates nuclear growth, and thereby modulates cell proliferation, overview
physiological function
LOX is the principal enzyme involved in crosslinking of collagen. Nuclear lysyl oxidase probably regulates nuclear growth, and thereby modulates cell proliferation, overview
physiological function
the enzyme induces epithelial-to-mesenchymal transition, the first step of metastasis/invasion
physiological function
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the lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia, thereby inducing epithelial to mesenchymal transition
physiological function
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enzyme activity contributes to collagen stabilization during liver fibrosis progression and limits spontaneous fibrosis reversal
physiological function
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lysyl oxidase activity is required for ordered collagen fibrillogenesis by tendon cells
physiological function
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the enzyme participates in primary tumor growth by directly impacting the senescence stability
physiological function
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the enzyme restricts Stat3-dependent cell proliferation and immune cell differentiation and inflammatory response
physiological function
crucial role of Lox in endometrial stromal cells
physiological function
J9NZK5
role in interlinking of collagen and elastin by oxidizing lysine residues
physiological function
the enzyme catalyzes the oxidative deamination of lysine residues of extracellular matrix proteins such as elastins and collagens and generate aldehyde groups. The oxidative deamination of lysine represents the foundational step for the cross-linking of elastin and collagen and thus is crucial for modeling of extracellular matrix
physiological function
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crucial role of Lox in endometrial stromal cells
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additional information
LOX expression opposes the effect of mutationally activated Ras, which is present in about 30% of human cancers. Proliferating cells dramatically increase their nuclear protein content when exposed to beta-aminopropionitrile, a highly specific lysyl oxidase inhibitor that reportedly blocks LOX inhibition of Ras-induced oocyte maturation
additional information
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LOX expression opposes the effect of mutationally activated Ras, which is present in about 30% of human cancers. Proliferating cells dramatically increase their nuclear protein content when exposed to beta-aminopropionitrile, a highly specific lysyl oxidase inhibitor that reportedly blocks LOX inhibition of Ras-induced oocyte maturation
additional information
LOX is a hypoxia-inducible amine oxidase, the activity of which enhances breast cancer cell invasion in vitro and in vivo. Specific inhibition of LOX activity by beta-aminopropionitrile or small interfering RNA decreased the invasiveness of T-47D and MCF-7 breast cancer cells attenuated for Pdcd4 function. Tumor suppressor Pdcd4 inhibits breast cancer cell migration and invasion in vitro. Loss of Pdcd4 in human nonmetastatic breast cancer cells increases the expression of lysyl oxidase mRNA
additional information
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LOX is a hypoxia-inducible amine oxidase, the activity of which enhances breast cancer cell invasion in vitro and in vivo. Specific inhibition of LOX activity by beta-aminopropionitrile or small interfering RNA decreased the invasiveness of T-47D and MCF-7 breast cancer cells attenuated for Pdcd4 function. Tumor suppressor Pdcd4 inhibits breast cancer cell migration and invasion in vitro. Loss of Pdcd4 in human nonmetastatic breast cancer cells increases the expression of lysyl oxidase mRNA
additional information
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lysyl oxidase inhibitor, beta-aminopropionitrile, diminishes the metastatic colonization potential of circulating breast cancer cells, detailed overview. LOX inhibition might be useful in metastasis prevention
additional information
lysyl oxidase inhibitor, beta-aminopropionitrile, diminishes the metastatic colonization potential of circulating breast cancer cells, detailed overview. LOX inhibition might be useful in metastasis prevention
additional information
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partial knockdown of three LOX genes, lox,loxl1 and loxl5b, sensitizes the developing embryo to dithiocarbamate exposure