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1.4.3.2: L-amino-acid oxidase

This is an abbreviated version!
For detailed information about L-amino-acid oxidase, go to the full flat file.

Word Map on EC 1.4.3.2

Reaction

an L-amino acid
+
H2O
 +
O2
=
a 2-oxo carboxylate
 +
NH3
 +
H2O2

Synonyms

AAD, ACTX-6, ACTX-8, Akbu-LAAO, APIT, apotxin, aromatic L-amino acid oxidase, Balt-LAAO-I, bordonein-L, Bpir-LAOO-1, CC-LPOX, DAA, Dolabellanin, escapin, head kidney and gill, IL4I1, Il4i1 protein, ink toxin 1, Interleukin Four Induced Gene 1 protein, L-AAO, L-AAO/MOG, L-AAO1, L-amino acid oxidase, L-amino acid: O2 oxidoreductase, L-amino acid:O2 oxidoreductase, L-amino acid:O2 oxidoreductase (deaminating), L-aminooxidase, L-Aox, L-phenylalanine oxidase, LAAO, LAAO-1, LAAO-I, LAAO-II, LAAO1, LAAO4, LAAOI, LAAOII, LAO, LAO1, M-LAO, ophio-amino-acid oxidase, Pm1, RoLAAO, sarA, Sebastes schlegeli antibacterial protein, Sebastes schlegelii antibacterial protein, SSAP, TJ-LAO, toxophallin, TSV-LAO

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.3 With oxygen as acceptor
                1.4.3.2 L-amino-acid oxidase

Source Tissue

Source Tissue on EC 1.4.3.2 - L-amino-acid oxidase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
most primary mediastinal B-cell lymphoma (89%) are positive for enzyme immunostaining with strong intracytoplasmic staining in up to 100% of tumor cells, CD19(+) and CD19(-) cells display enzyme activity
Manually annotated by BRENDA team
-
64% positive immunostaining, no correlation between staining and histological grade of the follicular lymphoma, in small lymphocytic lymphoma 40% positive, restricted to paraimmunoblasts of proliferative centers, high enzyme activity, 7fold higher than in spleen lysate
Manually annotated by BRENDA team
-
variable percentage of positive staining in several tissues, solid tumors, interfollicular areas, sinuses of reactive lymph nodes, red pulp of lymphoid follicles, thymus medulla, all lymphoma subtypes, particularly high enzyme expression in classical Hodgkin lymphoma and nodular lymphocyte predominant Hodgkin lymphoma cells
Manually annotated by BRENDA team
-
42% positive staining of classical Hodgkin lymphoma in Hodgkin and Reed Sternberg cells, 91% positive staining of nodular lymphocyte predominant Hodgkin lymphoma cells
Manually annotated by BRENDA team
-
lactating, tissue-specific LAO
Manually annotated by BRENDA team
lower expression rate than in head kidney and gill
Manually annotated by BRENDA team
-
weakly expressed
Manually annotated by BRENDA team
isozymes MPLAO1, MPLAO2, and MPLAO3
Manually annotated by BRENDA team
additional information