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1.4.3.21: primary-amine oxidase

This is an abbreviated version!
For detailed information about primary-amine oxidase, go to the full flat file.

Word Map on EC 1.4.3.21

Reaction

RCH2NH2
+
H2O
 +
O2
=
RCHO
 +
NH3
 +
H2O2

Synonyms

AGAO, AMAO2, AMAO3, amine oxidase 1, amine oxidase, copper containing, AO1, AO2, AOC2, AOC3, BAO, benzylamine oxidase, bovine plasma amine oxidase, bovine serum amine oxidase, BPAO, BSAO, CAO, Copper amine oxidase, copper amine oxidase 1, copper amine oxidase 8, copper-containing amine oxidase, copper-containing AO, copper-containing monoamine oxidase, copper-dependent amine oxidase, copper/quinone containing amine oxidase, Cu/TPQ amine oxidase, CuAO, CuAO1, CuAO2, CuAO3, CuAO8, EC 1.4.3.6, ECAO, ELAO, GPAO, grass pea amine oxidase, Hansenula polymorpha amine oxidase, HPAO, hPAO-1, HPAO-2, lentil seedling amine oxidase, LSAO, MAO-N, More, OVAO, PAO, pea seedling amine oxidase, plasma amine oxidase, PrAO, primary amine oxidase, primary-amine:oxygen oxidoreductase, PSAO, quinone- and copper-containing amine oxidase, quinone-containing copper amine oxidase, quinone-dependent amine oxidase, quinoprotein copper-containing amine oxidase, RAO, sainfoin amine oxidase, semicarbazide-sensitive amine oxidase, semicarbazide-sensitive amine oxidase/vascular adhesion protein-1, SSAO, SSAO/VAP-1, TPQ-containing CuAO, tynA, tyramine oxidase, copper-requiring, VAP-1, vascular adhesion protein 1, vascular adhesion protein-1

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.3 With oxygen as acceptor
                1.4.3.21 primary-amine oxidase

Specific Activity

Specific Activity on EC 1.4.3.21 - primary-amine oxidase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.00015
substrate benzylamine, at low substrate concentration
0.00023
substrate beta-phenylethylamine, at low substrate concentration
0.00025
substrate tyramine, at low substrate concentration
0.00078
substrate 1-methylhistamine, at low substrate concentration
0.00108
substrate tyramine, at high substrate concentration
0.00136
substrate beta-phenylethylamine, at high substrate concentration
0.00165
substrate 1-methylhistamine, at high substrate concentration
0.00193
substrate benzylamine, at high substrate concentration
0.0038
-
mutant enzyme D383E
0.00388
substrate serotonin, at high substrate concentration
0.016
-
copper-depleted wild type enzyme, with 4-N,N-dimethylaminomethyl benzylamine as substrate, in 100 mM potassium phosphate buffer, pH 7.2, 37°C
0.0193
-
copper depleted, reconstituted with Zn2+
0.0195
-
copper depleted, reconstituted with Ni2+
0.039
-
isoform AO1, crude extract, in 200 mM potassium phosphate buffer pH 7.6, at 30°C
0.0571
-
copper depleted enzyme
0.105
-
-
0.144
-
isoform AO2, crude extract, in 200 mM potassium phosphate buffer pH 7.6, at 30°C
0.213
-
copper depleted, reconstituted with Co2+
0.38
-
cobalt-substituted wild type enzyme, with 4-N,N-dimethylaminomethyl benzylamine as substrate, in 100 mM potassium phosphate buffer, pH 7.2, 37°C
0.894
-
copper depleted, reconstituted with Cu2+
1.13
-
native enzyme
11
-
wild-type enzyme
13.14
-
isoform AO2, after 91.3fold purification, in 200 mM potassium phosphate buffer pH 7.6, at 30°C
13.6
-
wild type enzyme, with 4-N,N-dimethylaminomethyl benzylamine as substrate, in 100 mM potassium phosphate buffer, pH 7.2, 37°C
2.08
-
enzyme from cultured aortic smooth muscle cells
3.1
-
tetrameric enzyme
5.6
-
recombinant enzyme, methylamine oxidation
6.302
-
isoform AO1, after 161.5fold purification, in 200 mM potassium phosphate buffer pH 7.6, at 30°C
6.7
-
dimeric enzyme
7
-
copper-reconstituted wild type enzyme, with 4-N,N-dimethylaminomethyl benzylamine as substrate, in 100 mM potassium phosphate buffer, pH 7.2, 37°C
additional information
-
1100.0-1200.0 units/mg, 1 unit is defined as the amount of enzyme catalyzing a change of 0.001 absorbance per minute at 25°C