1.4.99.5: glycine dehydrogenase (cyanide-forming)
This is an abbreviated version!
For detailed information about glycine dehydrogenase (cyanide-forming), go to the full flat file.
Word Map on EC 1.4.99.5
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1.4.99.5
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aeruginosa
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hcnabc
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fluorescens
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anr
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gaca
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fnr-like
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rhizosphere
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plant-beneficial
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pathosystems
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cyanogenesis
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oxysporum
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two-component
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2,4-diacetylphloroglucinol
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till
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pseudomonads
- 1.4.99.5
- aeruginosa
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hcnabc
- fluorescens
- anr
- gaca
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fnr-like
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rhizosphere
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plant-beneficial
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pathosystems
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cyanogenesis
- oxysporum
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two-component
- 2,4-diacetylphloroglucinol
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till
- pseudomonads
Reaction
+ 2 acceptor = + + 2 reduced acceptor
Synonyms
cyanogenic enzyme system, HCA, HCN synthase, HcnC, HCS, hydrogen cyanide synthase, synthase, hydrogen cyanide (9Cl)
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Natural Substrates Products
Natural Substrates Products on EC 1.4.99.5 - glycine dehydrogenase (cyanide-forming)
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REACTION DIAGRAM
glycine + FAD
HCN + CO2 + FADH2
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glycine is decarboxylated to HCN by the enzyme HCN synthase, the product of the hcnABC synthase gene cluster
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additional information
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cyanide produced by the enzyme is involved in virulence of the organism. Drosophila melanogaster exposed to cyanogenic Pseudomonas aeruginosa strains have high cyanide and low ATP concentrations in body extracts, and treatment with a cyanide antidote equalized survival of flies injected with cyanogenic and noncyanogenic strains. Strain PAO1 with a mutation in the hydrogen cyanide synthase gene cluster is much less toxic to flies than the parental cyanogenic strain or 2 knock-in strains, overview
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HCN + CO2 + 2 H2O
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glycine + O2
HCN + CO2 + 2 H2O
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