Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.4.99.5: glycine dehydrogenase (cyanide-forming)

This is an abbreviated version!
For detailed information about glycine dehydrogenase (cyanide-forming), go to the full flat file.

Word Map on EC 1.4.99.5

Reaction

glycine
+ 2 acceptor =
hydrogen cyanide
+
CO2
+ 2 reduced acceptor

Synonyms

cyanogenic enzyme system, HCA, HCN synthase, HcnC, HCS, hydrogen cyanide synthase, synthase, hydrogen cyanide (9Cl)

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.99 With unknown physiological acceptors
                1.4.99.5 glycine dehydrogenase (cyanide-forming)

Natural Substrates Products

Natural Substrates Products on EC 1.4.99.5 - glycine dehydrogenase (cyanide-forming)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
glycine + FAD
HCN + CO2 + FADH2
show the reaction diagram
-
glycine is decarboxylated to HCN by the enzyme HCN synthase, the product of the hcnABC synthase gene cluster
-
-
?
glycine + O2
HCN + CO2 + 2 H2O
show the reaction diagram
additional information
?
-
-
cyanide produced by the enzyme is involved in virulence of the organism. Drosophila melanogaster exposed to cyanogenic Pseudomonas aeruginosa strains have high cyanide and low ATP concentrations in body extracts, and treatment with a cyanide antidote equalized survival of flies injected with cyanogenic and noncyanogenic strains. Strain PAO1 with a mutation in the hydrogen cyanide synthase gene cluster is much less toxic to flies than the parental cyanogenic strain or 2 knock-in strains, overview
-
-
?