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1.5.1.1: 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]

This is an abbreviated version!
For detailed information about 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H], go to the full flat file.

Word Map on EC 1.5.1.1

Reaction

L-pipecolate
+
NAD(P)+
=
1-piperideine-2-carboxylate
+
NAD(P)H
+
H+

Synonyms

CphpI, CRYM, CtBP, cytosolic thyroid hormone binding protein, DELTA1-piperideine-2-carboxylate reductase, DELTA1-Pyr2C reductase, DELTA1-pyrroline-2-carboxylate reductase, ketimine reductase, KR/CRYM/CTBP, L-proline:NAD(P)+ 2-oxidoreductase, lhpI, More, mu-crystallin, NAD(P)H-dependent DELTA1-pyrroline-2-carboxylate reductase, P2C reductase, P2C/Pyr2C reductase, P2C/Pyr2C/ketimine reductase, PLP-dependent amino acid gamma-substitution enzyme, PYCR2, Pyr2C reductase, Pyr2C/Pip2C reductase, pyrroline-2-carboxylate reductase, reductase, pyrroline-2-carboxylate, THBP, thyroid hormone binding protein

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.1 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]

Specific Activity

Specific Activity on EC 1.5.1.1 - 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.000457
substrates: L-pipecolate, NAD+, pH 10.5, 30°C
0.0005
purified recombinant His-tagged enzyme, substrates L-pipecolate and NAD+, pH 6.5, 30°C
0.00435
substrates: L-pipecolate, NADP+, pH 10.5, 30°C
0.0044
purified recombinant His-tagged enzyme, substrates L-pipecolate and NADP+, pH 6.5, 30°C
0.0045
purified recombinant His-tagged enzyme, substrates L-proline and NAD+, pH 6.5, 30°C
0.00451
substrates: L-proline, NAD+, pH 10.5, 30°C
0.0464
substrates: DELTA1-piperidine-2-carboxylate, NADH, pH 6.5, 30°C
0.174
substrates: (4R)-DELTA1-pyrroline-4-hydroxy-2-carboxylate, NADPH, pH 6.5, 30°C
0.291
substrates: DELTA1-piperidine-2-carboxylate, NADPH, pH 6.5, 30°C
0.33
-
reduction of DELTA1-pyrroline-2-carboxylate, cosubstrate NADPH, pH 8.0, 30°C
0.67
-
reduction of DELTA1-piperidine-2-carboxylate, cosubstrate NADH, pH 8.0, 30°C
1.4
-
oxidation of L-pipecolate, cosubstrate NADP+, pH 8.0, 30°C
2.72
substrates: L-pipecolate, NAD+, pH 10.5, 30°C
2.92
substrates: L-pipecolate, NADP+, pH 10.5, 30°C
30.2
substrates: DELTA1-pyrroline-2-carboxylate, NADPH, pH 6.5, 30°C
4.76
substrates: DELTA1-pyrroline-2-carboxylate, NADH, pH 6.5, 30°C
5.18
substrates: L-proline, NADP+, pH 10.5, 30°C
5.4
-
oxidation of L-proline, cosubstrate NADP+, pH 8.0, 30°C
5.5
substrates: L-proline, NAD+, pH 10.5, 30°C
51
-
reduction of DELTA1-pyrroline-2-carboxylate, cosubstrate NADPH, pH 8.0, 30°C
92
-
reduction of DELTA1-piperidine-2-carboxylate, cosubstrate NADPH, pH 8.0, 30°C
additional information