1.5.1.11: D-octopine dehydrogenase
This is an abbreviated version!
For detailed information about D-octopine dehydrogenase, go to the full flat file.
Reaction
+
+
=
+
+
+
Synonyms
D-Octopine synthase, Dehydrogenase, octopine, flavin-containing opine dehydrogenase, N2-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase, N2-(D-1-carboxyethyl)-L-arginine:NAD+-oxidoreductase, OcDH, OCS, Octopine dehydrogenase, Octopine synthase, Octopine:NAD oxidoreductase, ODH, pTi_008
ECTree
Inhibitors
Inhibitors on EC 1.5.1.11 - D-octopine dehydrogenase
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1-Ethyl-3(3-dimethylaminopropyl)carbodiimide hydrochloride
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-
3-hydroxypyruvate
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inhibitor of octopine formation
5,5'-dithiobis(2-nitrobenzoate)
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
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5-Guanidinopentanoate
-
-
AMP
-
dead-end inhibition
diethyldicarbonate
-
reversal of the inhibition by hydroxylamine
diethyldithiocarbamate
-
-
epsilon-aminohexanoate
-
-
glyoxylate
-
inhibitor of octopine formation
homoarginine
-
inhibitor of octopine formation
NADH
-
substrate inhibition
NADPH
-
substrate inhibition
p-chloromercuribenzoate
-
p-chloromercuriphenyl sulfonic acid
L-Arg
-
-
L-Arg
-
linear non-competitive inhibitors with respect to octopine
L-Arg
-
substrate inhibition
L-Arg
-
noncompetitive with respect to D-octopine
NAD+
-
noncompetitive with respect to pyruvate, uncompetitive with respect to L-Arg
NADP+
-
-
NADP+
-
uncompetitive with respect to pyruvate
NEM
-
product inhibition
NEM
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competitive with respect to NAD+; non-competitive with respect to octopine
octopine
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product inhibition
octopine
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substrate inhibition above 2 mM, 50% product inhibition at 1.2 mM
octopine
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product inhibition
octopine
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product inhibition
octopine
-
substrate inhibition and product inhibition
p-chloromercuriphenyl sulfonic acid
-
reversed by dithiothreitol, NADH prevents inactivation
p-chloromercuriphenyl sulfonic acid
-
-
pyruvate
-
substrate inhibition
pyruvate
-
significantly more sensitive to substrate inhibition than the foot muscle enzyme
pyruvate
-
linear non-competitive inhibitors with respect to octopine
pyruvate
-
substrate inhibition
pyruvate
-
brain enzyme shows strong substrate inhibition, mantle muscle enzyme only slight inhibition
additional information
ODH is not inhibited by 5 or 10 mM iodacetamide
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additional information
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ODH is not inhibited by 5 or 10 mM iodacetamide
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