1.5.1.2: pyrroline-5-carboxylate reductase

This is an abbreviated version!
For detailed information about pyrroline-5-carboxylate reductase, go to the full flat file.

Reaction

Synonyms

1-pyrroline-5-carboxylate reductase, aldimine reductase, DELTA1-pyrroline-5-carboxylate reductase, DELTA1-pyrroline-5-carboxylate reductase 2, L-proline oxidase, L-proline-NAD(P)+ 5-oxidoreductase, L-proline:NAD(P)+ 5-oxidoreductase, MTR_7g090160, NADPH-L-DELTA'-pyrroline carboxylic acid reductase, P5C reductase, P5CDH, P5CR, PO, POX, PROC, proline oxidase, Pycr1, PYCR2, Pyr5C reductase, pyrroline-5-carboxylate dehydrogenase, pyrroline-5-carboxylate reductase, reductase, pyrroline-5-carboxylate, TcCLB.509207.90

ECTree

     1 Oxidoreductases

         1.5 Acting on the CH-NH group of donors

             1.5.1 With NAD⁺ or NADP⁺ as acceptor

                1.5.1.2 pyrroline-5-carboxylate reductase

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Results	in table
8	Activating Compound
45977	AA Sequence
9	Application
1	CAS Registry Number
23	Cloned(Commentary)
92	Cofactor
8	Crystallization (Commentary)
535	Disease/ Diagnostics
4	Expression
12	General Information
6	General Stability
67	IC50 Value
175	Inhibitors
33	kcat/KM [mM/s]
11	Ki Value [mM]
127	KM Value [mM]
25	Localization
14	Metals/Ions
27	Molecular Weight [Da]
41	Natural Substrates/ Products (Substrates)
116	Organism
9	Pathway
128	PDB ID
41	pH Optimum
7	pH Range
3	pH Stability
1	pI Value
9	Protein Variants
32	Purification (Commentary)
2	Reaction
27	Reaction Type
100	Reference
1	Renatured (Commentary)
82	Source Tissue
42	Specific Activity [micromol/min/mg]
12	Storage Stability
140	Substrates and Products (Substrate)
18	Subunits
70	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
1	Temperature Range [°C]
17	Temperature Stability [°C]
52	Turnover Number [1/s]

Expression

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Expression on EC 1.5.1.2 - pyrroline-5-carboxylate reductase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

in a mass spectrometry-based screening of metabolites in tissue sections from 256 esophageal squamous cell carcinoma (ESCC) patients, a significant upregulation of L-proline metabolism is found in the cancer region compared to the normal epithelium and muscle regions. Immunohistochemistry staining of the ESCC tissue sections identifies PYCR2 as the most enriched metabolic enzyme in the cancer region, consistent with increased L-proline found in the same tissue region

Homo sapiens

Q96C36

762678

oxidized low-density lipoproteins upregulate proline oxidase through nuclear receptor peroxisome proliferator-activated receptor gamma

Homo sapiens

-

711685

PI3K inhibition significantly reduces PYCR1 mRNA and protein expression. Nutrient stress induced by glucose deprivation also regulates PYCR1 expression

Homo sapiens

P32322

762610

upregulated micro-RNA miR-23b* in renal cancer is an important regulator of POX. Ectopic overexpression of miR-23b* in normal renal cells results in striking downregulation of POX, whereas POX expression increases markedly when endogenous miR-23b* is knocked down by its antagomirs in renal cancer cells

Homo sapiens

-

713158