1.5.1.2: pyrroline-5-carboxylate reductase
This is an abbreviated version!
For detailed information about pyrroline-5-carboxylate reductase, go to the full flat file.
Reaction
Synonyms
1-pyrroline-5-carboxylate reductase, aldimine reductase, DELTA1-pyrroline-5-carboxylate reductase, DELTA1-pyrroline-5-carboxylate reductase 2, L-proline oxidase, L-proline-NAD(P)+ 5-oxidoreductase, L-proline:NAD(P)+ 5-oxidoreductase, MTR_7g090160, NADPH-L-DELTA'-pyrroline carboxylic acid reductase, P5C reductase, P5CDH, P5CR, PO, POX, PROC, proline oxidase, Pycr1, PYCR2, Pyr5C reductase, pyrroline-5-carboxylate dehydrogenase, pyrroline-5-carboxylate reductase, reductase, pyrroline-5-carboxylate, TcCLB.509207.90
ECTree
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Substrates Products
Substrates Products on EC 1.5.1.2 - pyrroline-5-carboxylate reductase
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REACTION DIAGRAM
1-pyrroline-3-hydroxy-5-carboxylate + NAD(P)H
L-hydroxyproline + NAD(P)+
-
-
-
ir
DELTA1-piperideine-6-carboxylate + NADPH
L-pipecolic acid + NADP+
-
-
-
ir
DELTA1-pyrroline-5-carboxylate + NADH + H+
L-proline + NAD+
-
-
-
r
L-pipecolate + NADP+
DELTA1-piperideine 6-carboxylate + NADPH + H+
-
-
-
?
L-Pro + NAD(P)+
1-pyrroline-5-carboxylate + NAD(P)H
-
the enzyme plays a role as a downstream effector in p53-mediated apoptosis of renal carcinoma cells
-
-
?
L-proline benzyl ester + NAD+
L-pyrroline-5-carboxy benzyl ester + NADH
-
24% of activity with proline
-
-
?
L-proline methyl ester + NAD+
1-pyrroline-5-carboxy methyl ester + NADH
-
16% of activity with proline
-
-
?
L-proline t-butyl ester + NAD+
1-pyrroline-5-carboxy tert-butylester + NADH
-
10% of activity with proline
-
-
?
piperideine-6-carboxylate + NADH + H+
L-pipecolic acid + NAD+
-
-
L-pipecolic acid is the sole product
-
ir
piperideine-6-carboxylate + NADPH + H+
L-pipecolic acid + NADP+
-
-
L-pipecolic acid is the sole product
-
ir
additional information
?
-
-
not: D-proline, L-hydroxyproline, L-azatidine-2-carboxylate, no other amino acids
-
-
?
L-proline + NAD(P)+
-
-
-
r
1-pyrroline-5-carboxylate + NAD(P)H
L-proline + NAD(P)+
-
-
-
r
L-proline + NAD(P)+
-
reversible at pH values above 8 and higher substrate concentrations, oxidation of L-proline is strictly specific for the L-isomer
-
r
1-pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
specific for L-isomer
-
-
ir
1-pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
-
-
-
ir
1-pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
-
-
-
ir
1-pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
specific for L-isomer
-
-
?
1-pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
reaction is irreversible at pH 7.4, but reversible at pH 10.3
-
-
r
1-pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
-
-
-
?
1-pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
specific for L-isomer
-
-
ir
1-pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
-
-
?
1-pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
specific for L-isomer
-
-
ir
1-pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
specific for L-isomer
-
-
ir
1-pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
transfers the proS hydrogen at C-4 of the dihydropyridine ring of NAD(P)H to its substrate
-
-
?
1-pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
-
-
-
?
1-pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
-
-
-
?
1-pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
-
-
-
?
1-pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
-
-
-
?
1-pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
-
-
-
?
1-pyrroline-5-carboxylate + NADH + H+
L-proline + NAD+
-
-
-
-
r
1-pyrroline-5-carboxylate + NADH + H+
L-proline + NAD+
-
-
-
-
?
1-pyrroline-5-carboxylate + NADH + H+
L-proline + NAD+
-
-
-
-
?
1-pyrroline-5-carboxylate + NADH + H+
L-proline + NAD+
-
-
-
?
1-pyrroline-5-carboxylate + NADH + H+
L-proline + NAD+
-
-
-
?
1-pyrroline-5-carboxylate + NADPH + H+
L-proline + NADP+
-
-
-
-
r
1-pyrroline-5-carboxylate + NADPH + H+
L-proline + NADP+
-
activity assay, forward reaction
-
-
r
1-pyrroline-5-carboxylate + NADPH + H+
L-proline + NADP+
-
-
-
?
1-pyrroline-5-carboxylate + NADPH + H+
L-proline + NADP+
-
-
-
?
1-pyrroline-5-carboxylate + NADPH + H+
L-proline + NADP+
-
-
-
?
1-pyrroline-5-carboxylate + NAD(P)H
-
-
-
r
L-proline + NAD(P)+
1-pyrroline-5-carboxylate + NAD(P)H
-
-
-
r
1-pyrroline-5-carboxylate + NAD(P)H + H+
-
-
-
-
r
L-proline + NAD(P)+
1-pyrroline-5-carboxylate + NAD(P)H + H+
-
-
-
-
r
L-proline + NAD(P)+
1-pyrroline-5-carboxylate + NAD(P)H + H+
-
first step in proline metabolism the hepatocyte nuclear factors HNF4alpha and HNF1alpüha regulate proline metabolism in adult liver
-
-
?
1-pyrroline-3-thio-5-carboxylate + NAD(P)H
-
-
-
r
L-thioproline + NAD(P)+
1-pyrroline-3-thio-5-carboxylate + NAD(P)H
-
-
-
r
L-proline + NAD(P)+
-
discussion of role in vivo
-
-
?
pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
discussion of role in vivo
-
-
?
pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
discussion of role in vivo
-
-
?
pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
ping pong mechanism
-
-
?
pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
discussion of role in vivo
-
-
?
pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
ping pong mechanism
-
-
?
pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
discussion of role in vivo
-
-
?
pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
transfer of reducing equivalents from host plants to symbiotic partner
-
-
?
pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
third enzyme in proline pathway
-
-
?
pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
linkage to hexose monophosphate pathway
-
-
?
pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
discussion of role in vivo
-
-
?
pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
discussion of role in vivo
-
-
?
pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
discussion of role in vivo
-
-
?
pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
final reaction of proline synthesis
-
-
?
pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
discussion of role in vivo
-
-
?
pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
transfer of reducing equivalents into mitochondria, linkage to pentose phosphate pathway
-
-
?
pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
discussion of role in vivo
-
-
?