1.5.1.20: methylenetetrahydrofolate reductase [NAD(P)H]
This is an abbreviated version!
For detailed information about methylenetetrahydrofolate reductase [NAD(P)H], go to the full flat file.
Reaction
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Synonyms
10-methylenetetrahydrofolate reductase, 5,10-CH2-H4folate reductase, 5,10-methylenetetrahydrofolate reductase, 5,10-methylenetetrahydrofolate reductase (FADH2), 5,10-methylenetetrahydrofolate reductase (NADPH), 5,10-methylenetetrahydrofolic acid reductase, 5,10-methylenetetrahydropteroylglutamate reductase, 5-methylenetetrahydrofolate:NADP+ oxidoreductase, 5-methyltetrahydrofolate:(acceptor) oxidoreductase, 5-methyltetrahydrofolate:NAD oxidoreductase, 5-methyltetrahydrofolate:NAD+ oxidoreductase, 5-methyltetrahydrofolate:NADP+ oxidoreductase, AtMTHFR-1, EC 1.1.1.171, EC 1.1.1.68, EC 1.1.99.15, EC 1.7.99.5, HsMTHFR, MET13, methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase, methylenetetrahydrofolate reductase, methylenetetrahydrofolate reductase (NADPH), methylenetetrahydrofolic acid reductase, MetVF-type methylenetetrahydrofolate reductase, More, MTHFR, MTHFR2, N5,10-methylenetetrahydrofolate reductase, N5,N10-methylenetetrahydrofolate reductase, NADH:CH2-H4folate oxidoreductase, NapAB, reductase, methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate), reductase, methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide), respiratory nitrate reductase, type II-MTHFR
ECTree
Organism
Organism on EC 1.5.1.20 - methylenetetrahydrofolate reductase [NAD(P)H]
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UniProt
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ecotype Columbia, expression in Saccharomyces cerevisiae
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USDA110
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guinea pig
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Cercocebus sp.
monkey
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strain ATCC 23439
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expression in Saccharomyces cerevisiae
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UniProt
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UniProt
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formerly Mesorhizobium loti
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UniProt
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UniProt
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UniProt
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two isoenzymes, encoded by the genes MET12 and MET13
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UniProt
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synonym Sinorhizobium meliloti
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UniProt
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UniProt
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gene met13
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USDA110
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Uniprot
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392164, 437712, 437715, 437724, 437725, 437726, 654695, 654771, 671972, 672154, 689078 -
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392157, 392164, 392165, 392166, 437719, 437721, 437722, 437723, 437725, 654163, 677069, 684226, 684273, 684274, 684280, 684291, 684295, 684297, 684298, 684314, 684428, 684441, 684442, 684465, 684469, 684473, 684738, 684805, 685493, 685860, 685862, 685893, 685894, 685895, 685917, 685988, 685990, 685995, 686128, 686133, 686144, 686149, 686158, 686185, 686240, 686310, 686329 -
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UniProt
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686343, 686497, 686513, 686515, 686517, 686540, 686572, 686589, 686590, 686592, 686633, 686829, 686835, 686994, 687023, 687066, 687152, 687167, 687170, 687174, 687359, 687832, 687894, 687946, 687957, 688057, 688129, 688135, 688140, 688142, 688184 -
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688476, 688554, 688562, 688565, 688688, 688704, 688709, 688710, 688715, 688756, 688778, 689009, 689031 -
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689103, 689111, 689166, 689282, 689284, 689298, 689329, 689330, 689333, 689366, 689729, 689833, 689836, 690042, 690049, 690083, 690112, 690122, 690124, 690162, 690181, 690199, 690212, 697857, 698118, 699849, 702155, 712182, 713042, 724809 -
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healthy men and women aged 19-63 years
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patients with bipolar disorder
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patients with colorectal cancer
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patients with enzyme deficiency
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patients with Parkinson's disease
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patients with rheumatoid arthritis
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patients with spina bifida
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patients with systemic sclerosis
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pediatric patients with acute lymphoblastic leukemia
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recombinant enzyme, expression in Escherichia coli, Baculovirus system, or HEK293 cells
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SwissProt
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mouse model of mild Mthfr deficiency
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adult male Sprague-Dawley rats, fed a Purina lab chow diet
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gene met13
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two isoenzymes, encoded by the genes MET12 and MET13
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genes met9 and met11
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392149, 392152, 392153, 392155, 392156, 392160, 392162, 392164, 437711, 437712, 726099 -
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7 to 8-d-old piglets, milk from lactating sows
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a single enzyme with methylenetetrahydrofolate reductase and dopamine methyltransferase activity
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overview
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expression in Saccharomyces cerevisiae
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