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1.5.1.3: dihydrofolate reductase

This is an abbreviated version!
For detailed information about dihydrofolate reductase, go to the full flat file.

Word Map on EC 1.5.1.3

Reaction

5,6,7,8-tetrahydrofolate
+
NADP+
=
7,8-dihydrofolate
+
NADPH
+
H+

Synonyms

5,6,7,8-tetrahydrofolate: NADP+ oxidoreductase, 7,8-dihydrofolate reductase, At2g16370, At4g34570, bifunctional dihydrofolate reductase-thymidylate synthase, bifunctional TS-DHFR, BmDHFR, dehydrogenase, tetrahydrofolate, DFR-TS, DFR1, DfrA, DfrB, DHFR, DHFR type IIIC, DHFR-TS, DHFR-TS1, DHFR-TS2, DHFR2, DHFRL1, DHFRLS, dihydrofolate reductase, dihydrofolate reductase-like, dihydrofolate reductase-thymidylate synthase, dihydrofolate reductase:thymidylate synthase, dihydrofolic acid reductase, dihydrofolic reductase, EC 1.5.1.4, ecDHFR, folA, folA3, folic acid reductase, folic reductase, FolM, hDHFR, hDHFR-1, hDHFR-2, HjDHFR, hvDHFR1, hvDHFR2, LAU_0427, LBRM_06_0830, mDHFR, mjDHFR, More, myDHFR, NADPH-dihydrofolate reductase, pcDHFR, PKNH_0509600, ppDHFR, pteridine reductase, pteridine reductase:dihydrofolate reductase, PTR2, R-plasmid-encoded dihydrofolate reductase, R67 DHFR, R67 dihydrofolate reductase, reductase, dihydrofolate, S3DHFR, Smdhfr, Smp 175230, spDHFR, svDHFR, tcptr1, tetrahydrofolate dehydrogenase, THY-1, THY-2, thymidylate synthase-dihydrofolate reductase, thymidylate synthetase-dihydrofolate reductase, Trimethoprim resistance protein, TS-DHFR, WUBG_00817

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.3 dihydrofolate reductase

Substrates Products

Substrates Products on EC 1.5.1.3 - dihydrofolate reductase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
10-formyl-dihydrofolate + NADPH + H+
10-formyl-tetrahydrofolate + NADP+
show the reaction diagram
6-hydroxymethylpterin + NADPH
6-hydroxymethyl-7,8-dihydropterin + NADP+
show the reaction diagram
-
-
-
-
?
6-methylpterin + NADPH
6-methyl-7,8-dihydropterin + NADP+
show the reaction diagram
-
-
-
-
?
7,8-dihydrobiopterin + NADPH + H+
5,6,7,8-tetrahydrobiopterin + NADP+
show the reaction diagram
7,8-dihydrofolate + acetylpyridine adenine nucleotide, reduced
5,6,7,8-tetrahydrofolate + acetylpyridine adenine nucleotide, oxidized
show the reaction diagram
-
-
-
?
7,8-dihydrofolate + NADH + H+
5,6,7,8-tetrahydrofolate + NAD+
show the reaction diagram
7,8-dihydrofolate + NADPH
5,6,7,8-tetrahydrofolate + NADP+
show the reaction diagram
7,8-dihydrofolate + NADPH + H+
5,6,7,8-tetrahydrofolate + NADP+
show the reaction diagram
8-methylpterin + NADPH
8-methyl-7,8-dihydropterin + NADP+
show the reaction diagram
biopterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
show the reaction diagram
reaction of EC 1.5.1.33
-
-
?
D-erythro-7,8-neopterin + NADPH
?
show the reaction diagram
-
low activity
-
-
?
D-threo-neopterin + NADPH
?
show the reaction diagram
-
low activity
-
-
?
dihydrobiopterin + NADPH
? + NADP+
show the reaction diagram
-
10% of the activity with 7,8-dihydrofolate
-
-
?
dihydrofolate + NADPH + H+
tetrahydrofolate + NADP+
show the reaction diagram
dihydropteroate + NADPH
?
show the reaction diagram
-
-
-
-
?
dihydrosarcinapterin + NADPH + H+
tetrahydrosarcinapterin + NADP+
show the reaction diagram
-
-
-
?
folate + NADPH
5,6,7,8-tetrahydrofolate + NADP+
show the reaction diagram
folate + NADPH + H+
7,8-dihydrofolate + NADP+
show the reaction diagram
L-erythro-neopterin + NADPH
?
show the reaction diagram
-
-
-
-
?
L-threo-7,8-dihydroneopterin + NADPH
?
show the reaction diagram
-
low activity
-
-
?
L-threo-neopterin + NADPH
?
show the reaction diagram
-
-
-
-
?
pterin + NADPH
7,8-dihydropterin + NADP+
show the reaction diagram
-
low activity
-
-
?
xanthopterin + NADPH
?
show the reaction diagram
-
low activity
-
-
?
additional information
?
-