1.5.1.34: 6,7-dihydropteridine reductase

This is an abbreviated version!
For detailed information about 6,7-dihydropteridine reductase, go to the full flat file.

Reaction

Synonyms

7,8-dihydrobiopterin reductase, BmDhpr, DHPR, dicDHPR, dihydropteridine reductase, dihydropteridine reductase (NADH), DQPR gene product, EC 1.6.99.10, EC 1.6.99.7, EcDHPR, More, NADH-dihydropteridine reductase, NADPH-dihydropteridine reductase, NADPH-specific dihydropteridine reductase, NfsB, NprA nitroreductase, PTR2, QDPR, quinoid dihydropteridine reductase, reductase, dihydropteridine (reduced nicotinamide adenine dinucleotide)

ECTree

     1 Oxidoreductases

         1.5 Acting on the CH-NH group of donors

             1.5.1 With NAD⁺ or NADP⁺ as acceptor

                1.5.1.34 6,7-dihydropteridine reductase

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Results	in table
1596	AA Sequence
2	Application
2	CAS Registry Number
15	Cloned(Commentary)
89	Cofactor
7	Crystallization (Commentary)
719	Disease/ Diagnostics
1	Expression
12	General Information
5	General Stability
1	IC50 Value
161	Inhibitors
52	Ki Value [mM]
194	KM Value [mM]
4	Localization
48	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
108	Organism
6	Pathway
29	PDB ID
13	pH Optimum
2	pH Range
1	pH Stability
2	pI Value
30	Protein Variants
35	Purification (Commentary)
4	Reaction
3	Reaction Type
86	Reference
70	Source Tissue
40	Specific Activity [micromol/min/mg]
6	Storage Stability
131	Substrates and Products (Substrate)
29	Subunits
43	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
2	Temperature Stability [°C]
65	Turnover Number [1/s]

Cloned

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Cloned on EC 1.5.1.34 - 6,7-dihydropteridine reductase

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

-

Rattus norvegicus

-

484967

cloning of full-length cDNA, expression in COS cells

Homo sapiens

-

484964

dicDHPR gene (residues 1-231) cloned into pET-28b expression plasmid with hexahistidine tag and thrombin cleavage site, expression in Escherichia coli BL21 (DE3)

Dictyostelium discoideum

-

695339

DNA sequence determination and analysis, overexpression in Escherichia coli

Thermus thermophilus

-

655877

expressed as His-tag fusion protein in Escherichia coli

Rhodobacter capsulatus

-

686424

expressed in HEK-293T cells

Rattus norvegicus

-

724198

expression of cloned cDNA in Escherichia coli

Drosophila melanogaster

-

485009

expression of wild-type and several mutants in Escherichia coli

Rattus norvegicus

-

485005

expression of wild-type, G19D, W104G and T119insert mutant enzymes in Escherichia coli

Homo sapiens

-

485002

expression of wild-type, Y150H, Y150S, Y150F, Y150E, Y150K, G151S and G23D in Escherichia coli

Homo sapiens

-

485004

gene Dhpr, DNA and amino acid sequence determination and analysis, phylogenetic analysis, recombinant expression of His-tagged enzyme in Escherichia coli strain BL21(DE3)

Bombyx mori

-

742313

gene nfsB, recombinant expression of His-tagged enzyme in Escherichia coli strain BL21(DE3) as soluble protein

Escherichia coli

P38489

764413

high-level expression in Escherichia coli

Homo sapiens

-

484966

liver enzyme expressed in Escherichia coli

Rattus norvegicus

-

484965

recombinant expression in Escherichia coli

Physarum polycephalum

Q8WTJ2

654920