1.5.1.5: methylenetetrahydrofolate dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about methylenetetrahydrofolate dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.5.1.5

1.5.1.5

one-carbon

cyclohydrolase

thymidylate

trifunctional

methenyltetrahydrofolate

5,10-methenyltetrahydrofolate

10-formyltetrahydrofolate

mthfd1l

folate-dependent

formyltetrahydrofolate

folate-mediated

c1-tetrahydrofolate

3.5.4.9

transcobalamin

10-formyl-thf

6.3.4.3

remethylation

5,10-methenyl-thf

1-carbon

dehydrogenase-cyclohydrolase

megaloblastic

medicine

Reaction

Synonyms

5, 10-methylenetetrahydrofolate dehydrogenase, 5,10-CH2-THF dehydrogenase, 5,10-mehtylene tetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase/5,10-methylene tetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase, ADE3, bmMTHFD, CH2-THF dehydrogenase, Cpe FolD, dehydrogenasse-cyclohydrolase-synthetase, DHCH, DHCH1, FolD, methylene tetrahydrofolate dehydrogenase/cyclohydrolase, methylenetetrahydrofolate dehydrogenase, methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase, methylenetetrahydrofolate dehydrogenase/cyclohydrolase, methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase, MIS1, mitochondrial methylenetetrahydrofolate dehydrogenase, MTHFD, MTHFD1, MTHFD1 protein, MTHFD2, MTHFD2 protein, MTHFD2L, MTHFDC, N5,N10-methylenetetrahydrofolate dehydrogenase, N5,N10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase, NAD-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase, NADP-dependent 5,10-methylene-THF dehydrogenase

ECTree

1 Oxidoreductases

1.5 Acting on the CH-NH group of donors

1.5.1 With NAD⁺ or NADP⁺ as acceptor

1.5.1.5 methylenetetrahydrofolate dehydrogenase (NADP+)

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Results	in table
6	Activating Compound
45268	AA Sequence
3	Application
1	CAS Registry Number
21	Cloned(Commentary)
64	Cofactor
5	Crystallization (Commentary)
236	Disease/ Diagnostics
1	Expression
20	General Information
10	General Stability
14	IC50 Value
56	Inhibitors
20	kcat/KM [mM/s]
9	Ki Value [mM]
82	KM Value [mM]
22	Localization
14	Metals/Ions
30	Molecular Weight [Da]
58	Natural Substrates/ Products (Substrates)
421	Organism
16	Pathway
72	PDB ID
13	pH Optimum
3	pH Range
16	Protein Variants
36	Purification (Commentary)
1	Reaction
6	Reaction Type
66	Reference
57	Source Tissue
34	Specific Activity [micromol/min/mg]
13	Storage Stability
91	Substrates and Products (Substrate)
19	Subunits
73	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
2	Temperature Stability [°C]
28	Turnover Number [1/s]

Synonyms

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Synonyms on EC 1.5.1.5 - methylenetetrahydrofolate dehydrogenase (NADP+)

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5, 10-methylenetetrahydrofolate dehydrogenase

Homo sapiens

712807

5,10-CH2-THF dehydrogenase

2 entries

5,10-mehtylene tetrahydrofolate dehydrogenase

Leishmania major

700281

5,10-methenyltetrahydrofolate cyclohydrolase/5,10-methylene tetrahydrofolate dehydrogenase

Leishmania major

700281

5,10-methylenetetrahydrofolate dehydrogenase

3 entries

5,10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase

2 entries

ADE3

Saccharomyces cerevisiae

701402

bmMTHFD

Bombyx mori

764677

CH2-THF dehydrogenase

3 entries

Cpe FolD

Clostridium perfringens

743250

dehydrogenasse-cyclohydrolase-synthetase

Saccharomyces cerevisiae

DHCH

DHCH1

FolD

methylene tetrahydrofolate dehydrogenase/cyclohydrolase

Leishmania major

700281

methylenetetrahydrofolate dehydrogenase

8 entries

methylenetetrahydrofolate dehydrogenase (NADP+ dependent)

Homo sapiens

P11586

764552

methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase

Homo sapiens

P11586

698187

methylenetetrahydrofolate dehydrogenase/cyclohydrolase

Homo sapiens

P13995

757773

methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase

4 entries

MIS1

Saccharomyces cerevisiae

701402

mitochondrial methylenetetrahydrofolate dehydrogenase

MTHFD

MTHFD1

MTHFD1 protein

trifunctional cytosolic NADP(+)-dependent methylenetetrahydrofolate dehydrogenase, methenyltetrahydrofolate cyclohydrolase, and formyltetrahydrofolate synthetase

701402

MTHFD2

2 entries

MTHFD2 protein

Homo sapiens

bifunctional mitochondrial NAD(+)-dependent methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase, derived from trifunctional precursor by loss of the formyltetrahydrofolate synthetase domain, unique in mammals

701402

MTHFD2L

6 entries

MTHFDC

2 entries

N5,N10-methylenetetrahydrofolate dehydrogenase

N5,N10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase

2 entries

NAD-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase

Homo sapiens

701402

NADP-dependent 5,10-methylene-THF dehydrogenase

Arthrobacter globiformis

folD encodes a monofunctional enzyme

654937