1.5.1.6: formyltetrahydrofolate dehydrogenase

This is an abbreviated version!
For detailed information about formyltetrahydrofolate dehydrogenase, go to the full flat file.

Word Map on EC 1.5.1.6

1.5.1.6

one-carbon

folate-dependent

10-formyl-thf

nadp+-independent

aldh1b1

medicine

mthfd2

Reaction

Synonyms

10-FDH, 10-formyl tetrahydrofolate:NADP oxidoreductase, 10-formyl-H2PtGlu:NADP oxidoreductase, 10-formyl-H4folate dehydrogenase, 10-formyltetrahydrofolate dehydrogenase, 10-fTHF dehydrogenase, 10-FTHFDH, ALDH1L1, ALDH1L2, dehydrogenase, formyltetrahydrofolate, FBP-CI, FBP-CI proteins, FDH, folate-binding proteins, cytosol I, More, mtFDH, N10-formyltetrahydrofolate dehydrogenase, proteins, folate-binding, cytosol I

ECTree

1 Oxidoreductases

1.5 Acting on the CH-NH group of donors

1.5.1 With NAD⁺ or NADP⁺ as acceptor

1.5.1.6 formyltetrahydrofolate dehydrogenase

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Results	in table
10	Activating Compound
1971	AA Sequence
6	Application
1	CAS Registry Number
20	Cloned(Commentary)
102	Cofactor
2	Crystallization (Commentary)
195	Disease/ Diagnostics
1	General Information
2	General Stability
36	Inhibitors
6	Ki Value [mM]
24	KM Value [mM]
24	Localization
30	Molecular Weight [Da]
26	Natural Substrates/ Products (Substrates)
45	Organism
1	Oxidation Stability
2	Pathway
43	PDB ID
5	pH Optimum
1	pH Range
2	pI Value
5	Posttranslational Modification
27	Protein Variants
28	Purification (Commentary)
5	Reaction
5	Reaction Type
44	Reference
74	Source Tissue
17	Specific Activity [micromol/min/mg]
7	Storage Stability
107	Substrates and Products (Substrate)
23	Subunits
38	Synonyms
1	Systematic Name
18	Temperature Optimum [°C]
5	Turnover Number [1/s]

Purification

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Purification on EC 1.5.1.6 - formyltetrahydrofolate dehydrogenase

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4 entries

200fold partial purification

250fold purification

5-fTHFSepharose column chromatography, Sephacryl S-300 gel filtration, and MonoQ column chromatography

Rattus norvegicus

687640

co-purification with carbamoyl-phosphate synthetase 1 and betaine homocysteine S-methyltransferase using Kunitz-type soybean trypsin inhibitor-coupled Sepharose CL-4B column chromatography, Sephacryl S-200 gel filtration, and Superdex 200 gel filtration

Rattus norvegicus

674389

free of 10-formyltetrahydrofolate hydrolase activity

2 entries

intermediate domain and its mutants

Rattus norvegicus

P28037

656137

Kunitz-type soybean trypsin inhibitor-coupled Sepharose CL-4B column chromatography

Rattus norvegicus

674389

Ni-NTA column chromatography

Rattus norvegicus

685138

partial purification of MSN13/94, identified as forms of 10-formyltetrahydrofolate dehydrogenase

Mus musculus

392354

purification of a C707A mutant of FDH

Rattus norvegicus

392353

purification of N-terminal domain mutants and of a D124A mutant of FDH

Rattus norvegicus

392345

purification of N-terminal domain mutants and of a H106K mutant of FDH

Rattus norvegicus

392346

purification of recombinant 310 amino acid residue N-terminal domain

Rattus norvegicus

392347

purification of recombinant liver FDH

recombinant protein

separated from 10-formyltetrahydrofolate hydrolase, dehydrogenase and hydrolase are closely related and separately compartmentalized enzymes

Rattus norvegicus

392336