1.5.1.8: saccharopine dehydrogenase (NADP+, L-lysine-forming)
This is an abbreviated version!
For detailed information about saccharopine dehydrogenase (NADP+, L-lysine-forming), go to the full flat file.
Word Map on EC 1.5.1.8
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1.5.1.8
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alpha-aminoadipate
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hyperlysinemia
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pipecolic
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dihydrodipicolinate
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aminoadipic
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homocitrate
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medicine
- 1.5.1.8
- alpha-aminoadipate
- hyperlysinemia
-
pipecolic
- dihydrodipicolinate
-
aminoadipic
- homocitrate
- medicine
Reaction
Synonyms
AasS, dehydrogenase, saccharopine (nicotinamide adenine dinucleotide phosphate, lysine-forming), L-lysine-alpha-ketoglutarate reductase, LKR, LKR/SDH, LOR, LOR-SDH, lysine 2-oxoglutarate reductase, lysine 2-oxoglutarate reductase-saccharopine dehydrogenase, lysine alpha-ketoglutarate reductase, lysine ketoglutarate reductase, lysine ketoglutarate/reductase saccharopine dehydrogenase, lysine-2-oxoglutarate reductase, lysine-alpha-ketoglutarate reductase, lysine-ketoglutarate reductase, lysine-ketoglutarate reductase/saccharopine dehydrogenase, lysine-ketoglutaric reductase, lysine:alpha-ketoglutarate:TPNH oxidoreductase (epsilon-N-[glutaryl-2]-L-lysine forming), nllkr/sdh, saccharopine (nicotinamide adenine dinucleotide phosphate, lysine-forming) dehydrogenase, saccharopine dehydrogenase, saccharopine dehydrogenase (NADP, lysine-forming), saccharopine dehydrogenase (nicotinamide adenine dinucleotide phosphate, lysine-forming)
ECTree
1.5.1.8 saccharopine dehydrogenase (NADP+, L-lysine-forming)Advanced search results
results (
results (Inhibitors
Inhibitors on EC 1.5.1.8 - saccharopine dehydrogenase (NADP+, L-lysine-forming)
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
Calmidazolium
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0.04 mM, almost complete inhibition of Ca2+-dependent enhancement of enzyme activity, calmodulin antagonist
detergent
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e.g. Aerosol 22, Ultrawet 60L, deoxycholic acid, cetyltrimethyl ammonium bromide, complete inactivation
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L-Lysine-p-nitroanilide
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inhibition noncompetitive with L-lysine, competitive with 2-oxoglutarate
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide
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1.5 mM, almost complete inhibition of Ca2+-dependent enhancement of enzyme activity, calmodulin antagonist
Alkaline phosphatase
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dephosphorylation with alkaline phosphatase significantly inhibits enzyme activity in presence of lysine, inhibitory effect is dramatically stimulated by lysine binding to LKR, which alters the conformation exposing phosphate residues to the surface
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EGTA
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1 mM, 21% loss of activity, addition of 1.6 mM CaCl2 increases activity by 43%
EGTA
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1.6 mM, 70% loss of activity in crude extract, activity can be restored by addition of 1.6 mM CaCl2
L-ornithine
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complete inhibition of saccharopine formation, competitive with lysine
leucine
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complete inhibition of saccharopine formation, competitive with lysine
S-2-aminoethyl-L-cysteine
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inhibits when present in assay with L-lysine, possibly competitive with L-lysine
saccharopine
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1 mM, 30% inhibition, product inhibition; competitive with 2-oxoglutarate, noncompetitive with L-lysine, uncompetitive with NADPH
saccharopine
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product inhibition, competitive with 2-oxoglutarate, noncompetitive with L-lysine
additional information
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not inhibited by the detergents Lubrol PX, Tween 40, saccharopine formation is not inhibited by (NH4)2SO4
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additional information
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not inhibited by 40 mM ammonium chloride, inhibition by NH4+ is probably due to contamination with glutamic dehydrogenase
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additional information
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C-hordein suppression alters the enzyme activity differentially in different developmental stages, the extent varies among the transgenic lines., overview
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additional information
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lysine-oxoglutarate reductase shows time-dependent and protease-concentration-dependent inactivation by proteolysis followed by reactivation, saccharopine dehydrogenase-containing polypeptides obtained by prolonged digestion inhibit the activity of lysine-oxoglutarate reductase-containing polypeptides
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