1.5.3.17: non-specific polyamine oxidase

This is an abbreviated version!
For detailed information about non-specific polyamine oxidase, go to the full flat file.

Word Map on EC 1.5.3.17

1.5.3.17

spermidine

back-conversion

putrescine

peroxisomal

sativa

seedling

tetraamines

abscisic

anther

pollen

medicine

analysis

Reaction

Synonyms

AtPAO2, AtPAO3, AtPAO4, AtPAO5, Bjpao1, Bjpao2, EC 1.5.3.11, Fms1, LC036642, OsPAO1, PAO, PAO1, PAO2, PAO3, PAO5, polyamine oxidase 1, SelPAO5, slr5093, T-Spm oxidase, thermospermine oxidase

ECTree

1 Oxidoreductases

1.5 Acting on the CH-NH group of donors

1.5.3 With oxygen as acceptor

1.5.3.17 non-specific polyamine oxidase

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Results	in table
27	AA Sequence
3	Application
16	Cloned(Commentary)
11	Cofactor
2	Crystallization (Commentary)
3	Disease/ Diagnostics
13	Expression
28	General Information
18	Inhibitors
63	kcat/KM [mM/s]
11	Ki Value [mM]
118	KM Value [mM]
16	Localization
2	Metals/Ions
3	Molecular Weight [Da]
27	Natural Substrates/ Products (Substrates)
53	Organism
9	Pathway
6	PDB ID
22	pH Optimum
5	pH Range
5	pI Value
1	Posttranslational Modification
20	Protein Variants
11	Purification (Commentary)
4	Reaction
44	Reference
86	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
107	Substrates and Products (Substrate)
5	Subunits
50	Synonyms
1	Systematic Name
15	Temperature Optimum [°C]
3	Temperature Range [°C]
4	Temperature Stability [°C]
71	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.5.3.17 - non-specific polyamine oxidase

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aminoguanidine

dithioerythritol

up to 0.010 mM increase the enzyme activity, higher concentrations inhibit

690790

dithiothreitol

Ascaris suum

up to 0.010 mM increase the enzyme activity, higher concentrations inhibit

690790

guazatine

2 entries

Iproniazid

Ascaris suum

0.01 mM, 87% inhibition

690790

isoniazid

Ascaris suum

0.01 mM, 81% inhibition

MDL 27391

MDL 27695

MDL 72145

inhibited in a time-dependent manner. Half-life under saturation conditions is 0.8 min. MDL 72145 might be a chemical lead compound for the design of new chemotherapeutic agents against nematode infections

694540

MDL 72527

Ascaris suum

the specific inhibitor of mammalian polyamine oxidase, has no effect on the Ascaris suum enzyme

694540

N,N'-bis(2,3-butadienyl)-1,4-butanediamine

Bos taurus

i.e. MDL72527

742563

N1,N4-bis(2,3-butadienyl)-1,4-butanediamine

Branchiostoma japonicum

A0A0N7IZL9

2.5 mM, 50% inhibition of spermidine oxidation, 70% inhibition of N1-acetylspermine oxidation; 2.5 mM, 50% inhibition of spermidine oxidation, 70% inhibition of spermine oxidation

N8-Acetylspermidine

NEM

0.01 mM, 85% inhibition

putrescine

triethylenetetramine

competitive inhibitor with spermine as substrate

742563

additional information

Ascaris suum

the polyamine oxidase inhibitor MDL 72527 has no effect on the parasite polyamine oxidase activity

690790