1.5.5.2: proline dehydrogenase

This is an abbreviated version!
For detailed information about proline dehydrogenase, go to the full flat file.

Word Map on EC 1.5.5.2

1.5.5.2

putas

schizophrenia

pyrroline-5-carboxylate

delta1-pyrroline-5-carboxylate

flavoenzyme

psycho

hyperprolinemia

microdeletion

schizoaffective

2-acetyl-1-pyrroline

rgs4

velocardiofacial

proline-dependent

digeorge

dysbindin

fragrant

prolidase

synthesis

Reaction

Synonyms

bifunctional dye-linked L-proline/NADH dehydrogenase complex, dye-linked L-proline dehydrogenase, EC 1.5.99.8, FAD-dependent L-proline oxidoreductase, JcProDH, L-proline dehydrogenase, L-proline:FAD oxidoreductase, PdhB, PDHbeta, PF1246, PF1798, PH1364, PH1751, PRODH, proDH-B1, proDH-B2, PRODH/POX, ProDH1, proline dehydrogenase, proline dehydrogenase 1, proline dehydrogenase/oxidase, proline oxidase, proline/P5C dehydrogenase, prub, PutA, PutA flavoprotein, PutA proline dehydrogenase, Tc00.1047053506411.30, TcPRODH, TK0117, TK0122, TPpdhbeta, TtProDH

ECTree

1 Oxidoreductases

1.5 Acting on the CH-NH group of donors

1.5.5 With a quinone or similar compound as acceptor

1.5.5.2 proline dehydrogenase

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Results	in table
28048	AA Sequence
2	Application
1	CAS Registry Number
17	Cloned(Commentary)
28	Cofactor
7	Crystallization (Commentary)
181	Disease/ Diagnostics
9	Expression
35	General Information
1	General Stability
37	Inhibitors
26	kcat/KM [mM/s]
10	Ki Value [mM]
33	KM Value [mM]
11	Localization
1	Metals/Ions
19	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
52	Organism
12	Pathway
25	PDB ID
13	pH Optimum
1	pH Range
2	pH Stability
1	pI Value
19	Protein Variants
17	Purification (Commentary)
2	Reaction
3	Reaction Type
43	Reference
8	Source Tissue
9	Specific Activity [micromol/min/mg]
65	Substrates and Products (Substrate)
31	Subunits
92	Synonyms
1	Systematic Name
12	Temperature Optimum [°C]
1	Temperature Range [°C]
14	Temperature Stability [°C]
23	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.5.5.2 - proline dehydrogenase

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2-Thenoyltrifluoroacetone

2 entries

5-ethylpentyl-barbituric acid

Escherichia coli

membrane-associated enzyme, not soluble enzyme

acetate

competitive

antimycin A

cyanide

only membrane-associated enzyme, not soluble enzyme

D-lactate

GuHCl

enzyme unfolding at 1 M, 0.5 M is not enough for proper unfolding. The fusion protein forms visible aggregates due to unfolding of MBP

742162

KCN

2 entries

L-azetidine-2-carboxylate

competitive

L-lactate

L-proline

L-tetrahydro-2-furoic acid

2 entries

L-thiazolidine-4-carboxylate

competitive

Lactate

N-propargylglycine

irreversibly inactivates PutA by covalently linking the flavin N(5) atom to the epsilon-amino of Lys329. Inactivation locks PutA into a conformation that may mimic the proline-reduced, membrane-associated form

711252

pyrrolidone-5-carboxylate

pyruvate

rotenone

succinate

thiazolidine-2-carboxylate

Sinorhizobium meliloti

F7X6I3

a mechanism-based inactivator of PRODH. PRODH catalyzes the oxidation of thiazolidine-2-carboxylate at the C atom adjacent to the S atom of the thiazolidine ring (C5). Then, the N5 atom of the reduced FAD attacks the C5 of the oxidized T2C species, resulting in a covalent adduct

763802

additional information

2 entries