1.5.8.3: sarcosine dehydrogenase
This is an abbreviated version!
For detailed information about sarcosine dehydrogenase, go to the full flat file.
Word Map on EC 1.5.8.3
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1.5.8.3
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dimethylglycine
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sarcosinemia
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folate-binding
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dmgdh
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l-pipecolic
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pipox
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medicine
- 1.5.8.3
- dimethylglycine
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sarcosinemia
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folate-binding
- dmgdh
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l-pipecolic
- pipox
- medicine
Reaction
Synonyms
EC 1.5.99.1, monomethylglycine dehydrogenase, sarcosine N-demethylase, sarcosine:(acceptor) oxidoreductase (demethylating), sarcosine:electron-transfer flavoprotein oxidoreductase (demethylating), SARDH, SDH
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Activating Compound
Activating Compound on EC 1.5.8.3 - sarcosine dehydrogenase
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TMEFF2
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i.e. full-length follistatin motifs 2, the enzyme interacts with the full-length follistatin motifs 2, TMEFF2. TMEFF2 has a dual mode of action. The ectodomain does not bind to SARDH. Ectopic expression of wild-type full-length TMEFF2 inhibits soft agar colony formation, cellular invasion, and migration and increases cellular sensitivity to apoptosis. Expression of the full-length TMEFF2 but not the ectodomain results in a decreased level of sarcosine in the cells
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additional information
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immobilization of the enzyme on sorbitan esters Span 80 and Tween 80 containing phospholipid lecithin-bilayer membrane vesicles increases the enzyme activity and stability
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