1.5.8.4: dimethylglycine dehydrogenase

This is an abbreviated version!
For detailed information about dimethylglycine dehydrogenase, go to the full flat file.

Reaction

Synonyms

Csal_0990, DdhC, DMGDH, EC 1.5.99.2, Me2GlyDH, mMe2GlyDH, N,N-dimethylglycine oxidase, pMe2GlyDH

ECTree

     1 Oxidoreductases

         1.5 Acting on the CH-NH group of donors

             1.5.8 With a flavin or flavoprotein as acceptor

                1.5.8.4 dimethylglycine dehydrogenase

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Results	in table
264	AA Sequence
4	Application
1	CAS Registry Number
8	Cloned(Commentary)
32	Cofactor
6	Crystallization (Commentary)
43	Disease/ Diagnostics
3	Expression
7	General Information
5	Inhibitors
12	kcat/KM [mM/s]
22	KM Value [mM]
20	Localization
5	Metals/Ions
9	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
32	Organism
5	Pathway
6	PDB ID
5	pH Optimum
4	Protein Variants
10	Purification (Commentary)
1	Reaction
4	Reaction Type
28	Reference
1	Renatured (Commentary)
27	Source Tissue
8	Specific Activity [micromol/min/mg]
2	Storage Stability
47	Substrates and Products (Substrate)
7	Subunits
15	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
5	Temperature Stability [°C]
18	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.5.8.4 - dimethylglycine dehydrogenase

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SYSTEMATIC NAME

IUBMB Comments

N,N-dimethylglycine,5,6,7,8-tetrahydrofolate:electron-transferflavoprotein oxidoreductase (demethylating,5,10-methylenetetrahydrofolate-forming)

A flavoprotein, containing a histidyl(Npi)-(8alpha)FAD linkage at position 91 in the human protein. An imine intermediate is channeled from the FAD binding site to the 5,6,7,8-tetrahydrofolate binding site through a 40 A tunnel [5,8,9]. In the absence of 5,6,7,8-tetrahydrofolate the enzyme forms formaldehyde [5,9].