1.5.99.4: nicotine dehydrogenase
This is an abbreviated version!
For detailed information about nicotine dehydrogenase, go to the full flat file.
Word Map on EC 1.5.99.4
-
1.5.99.4
-
arthrobacter
-
molybdopterins
-
barkeri
-
nicotinovorans
-
molybdenum
-
xanthine
-
6-hydroxynicotine
-
selenium-containing
-
selenocysteine
-
molybdenum-containing
-
selenoproteins
-
selenide
-
nicotine-degrading
-
6-hydroxy-l-nicotine
- 1.5.99.4
- arthrobacter
- molybdopterins
- barkeri
- nicotinovorans
- molybdenum
- xanthine
- 6-hydroxynicotine
-
selenium-containing
- selenocysteine
-
molybdenum-containing
-
selenoproteins
- selenide
-
nicotine-degrading
- 6-hydroxy-l-nicotine
Reaction
Synonyms
6-hydroxy-D-nicotine oxidase, 6-hydroxy-L-nicotine oxidase, D-nicotine oxidase, NctA, NDH, NdhAB, nicotine dehydrogenase, nicotine oxidase, nicotinic acid hydroxylase
ECTree
1.5.99.4 nicotine dehydrogenaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 1.5.99.4 - nicotine dehydrogenase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(R)-nicotine + acceptor + H2O
(R)-6-hydroxynicotine + reduced acceptor
-
-
-
?
(S)-nicotine + 2,6-dichlorophenolindophenol + H2O
(S)-6-hydroxynicotine + reduced 2,6-dichlorophenolindophenol
(S)-nicotine + acceptor
(S)-nicotine delta1',5'-iminium ion + reduced acceptor
-
-
-
?
(S)-nicotine + acceptor + H2O
nicotine-N-oxide + reduced acceptor
-
-
-
?
(S)-nicotine + acceptor + H2O
nornicotine + reduced acceptor + ?
-
-
-
?
(S)-nicotine + brilliant cresyl blue + H2O
(S)-6-hydroxynicotine + reduced brilliant cresyl blue
-
-
-
-
r
(S)-nicotine + menadione + H2O
(S)-6-hydroxynicotine + menadiol
-
-
-
-
r
(S)-nicotine + methylene blue + H2O
(S)-6-hydroxynicotine + reduced methylene blue
-
-
-
-
r
(S)-nicotine + vitamin K5 + H2O
(S)-6-hydroxynicotine + reduced vitamin K5
-
-
-
-
r
anabasine + acceptor + H2O
6-hydroxyanabasine + reduced acceptor
-
-
-
?
D-nicotine + acceptor + H2O
(R)-6-hydroxynicotine + reduced acceptor
isozyme specific for the D-isomer
-
-
?
DL-nicotine + ?
6-hydroxynicotine + ?
-
first enzyme in nicotine pathway
-
?
nicotine-N-oxide + acceptor + H2O
6-hydroxynicotine-N-oxide + reduced acceptor
-
-
-
?
(RS)-nicotine + acceptor + H2O
pseudooxynicotine + reduced acceptor
via N-methylmyosmine, which then spontaneously hydrolyzes to pseudooxynicotine. The two enantiomers are degraded at approximately the same rate, indicating that NOX does not show chiral selectivity
-
-
?
(RS)-nicotine + acceptor + H2O
pseudooxynicotine + reduced acceptor
via N-methylmyosmine, which then spontaneously hydrolyzes to pseudooxynicotine. The two enantiomers are degraded at approximately the same rate, indicating that NOX does not show chiral selectivity
-
-
?
(S)-nicotine + 2,6-dichlorophenolindophenol + H2O
(S)-6-hydroxynicotine + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
(S)-nicotine + 2,6-dichlorophenolindophenol + H2O
(S)-6-hydroxynicotine + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
(S)-nicotine + 2,6-dichlorophenolindophenol + H2O
(S)-6-hydroxynicotine + reduced 2,6-dichlorophenolindophenol
-
-
-
-
r
(S)-nicotine + acceptor + H2O
pseudooxynicotine + reduced acceptor
via N-methylmyosmine, which then spontaneously hydrolyzes to pseudooxynicotine. The two enantiomers are degraded at approximately the same rate, indicating that NOX does not show chiral selectivity
-
-
?
(S)-nicotine + acceptor + H2O
pseudooxynicotine + reduced acceptor
via N-methylmyosmine, which then spontaneously hydrolyzes to pseudooxynicotine. The two enantiomers are degraded at approximately the same rate, indicating that NOX does not show chiral selectivity
-
-
?
(S)-nicotine + pseudoazurin + H2O
(S)-6-hydroxynicotine + reduced pseudoazurin
-
acceptor pseudoazurin is a single-electron carrier and is able to bind a single copper atom while accepting or discharging one electron
-
-
?
(S)-nicotine + pseudoazurin + H2O
(S)-6-hydroxynicotine + reduced pseudoazurin
-
acceptor pseudoazurin is a single-electron carrier and is able to bind a single copper atom while accepting or discharging one electron
-
-
?
L-nicotine + acceptor + H2O
(S)-6-hydroxynicotine + reduced acceptor
-
-
-
-
?
L-nicotine + acceptor + H2O
(S)-6-hydroxynicotine + reduced acceptor
Nocardioides sp. JS614 / ATCC BAA-499
-
-
-
-
?
L-nicotine + acceptor + H2O
(S)-6-hydroxynicotine + reduced acceptor
-
-
-
-
?
L-nicotine + acceptor + H2O
(S)-6-hydroxynicotine + reduced acceptor
isozyme strictly specific for the L-isomer
-
-
?
nicotine + acceptor + H2O
6-hydroxynicotine + reduced acceptor
-
non-stereospecific enzyme if grown on L-nicotine, assayed with 2,6-dichlorophenolindophenol
-
?
nicotine + acceptor + H2O
6-hydroxynicotine + reduced acceptor
-
brilliant cresyl blue, methylene blue, 5-hydroxy-1,4-naphthoquinone, 2,6-dichlorophenolindophenol, menadione and vitamin K5 used as electron acceptors
-
?
nicotine + acceptor + H2O
6-hydroxynicotine + reduced acceptor
-
preferentially 2,6-dichlorophenolindophenol used as electron acceptor
-
?
nicotine + acceptor + H2O
6-hydroxynicotine + reduced acceptor
-
molybdate is required
-
?
nicotine + acceptor + H2O
6-hydroxynicotine + reduced acceptor
-
molybdate is required
-
?
nicotine + acceptor + H2O
6-hydroxynicotine + reduced acceptor
-
first enzyme in the nicotine degradation pathway
-
?
nicotine + acceptor + H2O
6-hydroxynicotine + reduced acceptor
-
first enzyme in the nicotine degradation pathway
-
?
nicotine + acceptor + H2O
6-hydroxynicotine + reduced acceptor
-
-
-
?
nicotine + acceptor + H2O
6-hydroxynicotine + reduced acceptor
-
-
-
?
nicotinic acid + acceptor + H2O
6-hydroxynicotinic acid + reduced acceptor
-
-
-
?
nicotinic acid + acceptor + H2O
6-hydroxynicotinic acid + reduced acceptor
-
cytochrome-linked oxidation, hydroxylation
-
?
nicotinic acid + acceptor + H2O
6-hydroxynicotinic acid + reduced acceptor
-
cytochrome-linked oxidation, hydroxylation
-
?
nicotinic acid + acceptor + H2O
6-hydroxynicotinic acid + reduced acceptor
-
2,6-dichlorophenolindophenol used as electron acceptor
-
?
nicotinic acid + acceptor + H2O
6-hydroxynicotinic acid + reduced acceptor
-
2,6-dichlorophenolindophenol used as electron acceptor
-
?
nornicotine + acceptor + H2O
6-hydroxynornicotine + reduced acceptor
-
-
-
?
nornicotine + acceptor + H2O
6-hydroxynornicotine + reduced acceptor
-
-
-
?
additional information
?
-
-
NAD(P)+, O2, and ferredoxin cannot serve as electron acceptors
-
-
-
additional information
?
-
-
NAD(P)+, O2, and ferredoxin cannot serve as electron acceptors
-
-
-
additional information
?
-
enzyme expression and activity is regulated by substrate and product level via transcription repressor HdnoR
-
-
?
additional information
?
-
enzyme expression and activity is regulated by substrate and product level via transcription repressor HdnoR
-
-
?
additional information
?
-
enzyme expression and activity is regulated by substrate and product level via transcription repressor HdnoR
-
-
?
additional information
?
-
organism can grow on L-nicotine since it is converted to D-nicotine by a racemase
-
-
?
additional information
?
-
organism can grow on L-nicotine since it is converted to D-nicotine by a racemase
-
-
?
additional information
?
-
organism can grow on L-nicotine since it is converted to D-nicotine by a racemase
-
-
?
