1.5.99.B2: proline dehydrogenase (acceptor)
This is an abbreviated version!
For detailed information about proline dehydrogenase (acceptor), go to the full flat file.
Reaction
Synonyms
APE_1267.1, dye-linked L-proline dehydrogenase, L-proDH, L-proline dehydrogenase, L-proline: FAD oxidoreductase, L-proline:FAD oxidoreductase, LPDH, PDH, PDH1, PDH2, PF1246, PF1798, PH1364, PH1751, PIG6, POX, Pro dehydrogenase, PRODH, ProDH1, ProDH2, proline dehydrogenase, proline oxidase, prub, PutA, TK0117, TK0122, TPpdhB, TPpdhB2, TtProDH
ECTree
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Reference
Reference on EC 1.5.99.B2 - proline dehydrogenase (acceptor)
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Meile, L.; Leisinger, T.
Purification and properties of the bifunctional proline dehydrogenase/1-pyrroline-5-carboxylate dehydrogenase from Pseudomonas aeruginosa
Eur. J. Biochem.
129
67-75
1982
Pseudomonas aeruginosa, Salmonella enterica subsp. enterica serovar Typhimurium
Elthon, T.E.; Stewart, C.R.
Proline oxidation in corn mitochondia
Plant Physiol.
70
567-572
1982
Zea mays
Mommsen, T.P.; Hochachka, P.W.
Respiratory and enzymatic properties of squid heart mitochondria
Eur. J. Biochem.
120
345-350
1981
Illex illecebrosus
Balboni, E.; Hecht, R.I.
Studies on the inner mitochondrial membrane localization of proline dehydrogenase
Biochim. Biophys. Acta
462
171-176
1977
Phormia regina
Kramar, R.
Solubilization of proline dehydrogenase from rat liver mitochondria
Hoppe-Seyler's Z. Physiol. Chem.
352
1267-1270
1971
Rattus norvegicus
Crabtree, B.; Newsholme, E.A.
The activities of proline dehydrogenase, glutamate dehydrogenase, aspartate-oxoglutarate aminotransferase and alanine-oxoglutarate aminotransferase in some insect flight muscles
Biochem. J.
117
1019-1021
1970
insecta
Hansford, R.G.; Sacktor, B.
The control of the oxidation of proline by isolated flight muscle mitochondria
J. Biol. Chem.
245
991-994
1970
Phormia regina
Mani, S.; Van de Cotte, B.; Van Montagu, M.; Verbruggen, N.
Altered levels of proline dehydrogenase cause hypersensitivity to proline and its analogs in Arabidopsis
Plant Physiol.
128
73-83
2002
Arabidopsis thaliana
Tritsch, D.; Mawlawi, H.; Biellmann, J.F.
Mechanism-based inhibition of proline dehydrogenase by proline analogues
Biochim. Biophys. Acta
1202
77-81
1993
Drosophila melanogaster, Glossina morsitans, Rattus norvegicus
Lee, J.H.; Park, N.Y.; Lee, M.H.; Choi, S.H.
Characterization of the Vibrio vulnificus putAP operon, encoding proline dehydrogenase and proline permease, and its differential expression in response to osmotic stress
J. Bacteriol.
185
3842-3852
2003
Vibrio vulnificus
Abraham, E.; Rigo, G.; Szekely, G.; Nagy, R.; Koncz, C.; Szabados, L.
Light-dependent induction of proline biosynthesis by abscisic acid and salt stress is inhibited by brassinosteroid in Arabidopsis
Plant Mol. Biol.
51
363-372
2003
Arabidopsis sp.
Miller, G.; Stein, H.; Honig, A.; Kapulnik, Y.; Zilberstein, A.
Responsive modes of Medicago sativa proline dehydrogenase genes during salt stress and recovery dictate free proline accumulation
Planta
222
70-79
2005
Medicago sativa (Q6JA03)
White, T.A.; Tanner, J.J.
Cloning, purification and crystallization of Thermus thermophilus proline dehydrogenase
Acta Crystallogr. Sect. F
61
737-739
2005
Thermus thermophilus
Monaghan, P.J.; Leys D.; Scrutton N.S.
Crystallization and preliminary X-ray diffraction analysis of a flavoenzyme amine dehydrogenase/oxidase from Pyrococcus furiosus DSM 3638
Acta Crystallogr. Sect. F
61
756-758
2005
Pyrococcus furiosus
Kawakami, R.; Sakuraba, H.; Tsuge, H.; Goda, S.; Katunuma, N.; Ohshima, T.
A second novel dye-linked L-proline dehydrogenase complex is present in the hyperthermophilic archaeon Pyrococcus horikoshii OT-3
FEBS J.
272
4044-4054
2005
Pyrococcus horikoshii, Pyrococcus horikoshii OT-3
Tsuge, H.; Kawakami, R.; Sakuraba, H.; Ago, H.; Miyano, M.; Aki, K.; Katunuma, N.; Ohshima, T.
Crystal structure of a novel FAD-, FMN-, and ATP-containing L-proline dehydrogenase complex from Pyrococcus horikoshii
J. Biol. Chem.
280
31045-31049
2005
Pyrococcus horikoshii, Pyrococcus horikoshii (O59089), Pyrococcus horikoshii OT-3 (O59089)
Hu, C.A.; Donald, S.P.; Yu, J.; Lin, W.W.; Liu, Z.; Steel, G.; Obie, C.; Valle, D.; Phang, J.M.
Overexpression of proline oxidase induces proline-dependent and mitochondria-mediated apoptosis
Mol. Cell. Biochem.
295
85-92
2007
Homo sapiens
Kolodyazhnaya, Y.S.; Titov, S.E.; Kochetov, A.V.; Komarova, M.L.; Romanova, A.V.; Koval, V.S.; Shumny, V.K.
Evaluation of salt tolerance in Nicotiana tabacum plants bearing an antisense suppressor of the proline dehydrogenase gene
Russ. J. Genet.
42
212-214
2006
Nicotiana tabacum
-
Maxwell, S.A.; Kochevar, G.J.
Identification of a p53-response element in the promoter of the proline oxidase gene
Biochem. Biophys. Res. Commun.
369
308-313
2008
Homo sapiens (O43272)
White, T.A.; Johnson, W.H.; Whitman, C.P.; Tanner, J.J.
Structural basis for the inactivation of Thermus thermophilus proline dehydrogenase by N-propargylglycine
Biochemistry
47
5573-5580
2008
Thermus thermophilus (Q72IB8)
Monaghan, P.J.; Leys, D.; Scrutton, N.S.
Mechanistic aspects and redox properties of hyperthermophilic L-proline dehydrogenase from Pyrococcus furiosus related to dimethylglycine dehydrogenase/oxidase
FEBS J.
274
2070-2087
2007
Pyrococcus furiosus
Huang, T.C.; Huang, Y.W.; Hung, H.J.; Ho, C.T.; Wu, M.L.
DELTA1-pyrroline-5-carboxylic acid formed by proline dehydrogenase from the Bacillus subtilis ssp. natto expressed in Escherichia coli as a precursor for 2-acetyl-1-pyrroline
J. Agric. Food Chem.
55
5097-5102
2007
Bacillus subtilis (Q8RMG1)
White, T.A.; Krishnan, N.; Becker, D.F.; Tanner, J.J.
Structure and kinetics of monofunctional proline dehydrogenase from Thermus thermophilus
J. Biol. Chem.
282
14316-14327
2007
Thermus thermophilus (Q72IB8)
Kim, K.Y.; Ahn, J.H.; Cheon, H.G.
Apoptotic action of peroxisome proliferator-activated receptor-gamma activation in human non small-cell lung cancer is mediated via proline oxidase-induced reactive oxygen species formation
Mol. Pharmacol.
72
674-685
2007
Homo sapiens
Ribarits, A.; Abdullaev, A.; Tashpulatov, A.; Richter, A.; Heberle-Bors, E.; Touraev, A.
Two tobacco proline dehydrogenases are differentially regulated and play a role in early plant development
Planta
225
1313-1324
2007
Nicotiana tabacum (Q6GUH3), Nicotiana tabacum (Q6GUH4)
Di Rosa, G.; Pustorino, G.; Spano, M.; Campion, D.; Calabro, M.; Aguennouz, M.; Caccamo, D.; Legallic, S.; Sgro, D.L.; Bonsignore, M.; Tortorella, G.
Type I hyperprolinemia and proline dehydrogenase (PRODH) mutations in four Italian children with epilepsy and mental retardation
Psychiatr. Genet.
18
40-42
2008
Homo sapiens
Kolodyazhnaya, Y.S.; Titov, S.E.; Kochetov, A.V.; Trifonova, E.A.; Romanova, A.V.; Komarova, M.L.; Koval, V.S.; Shumny, V.K.
Tobacco transformants expressing antisense sequence of proline dehydrogenase gene possess tolerance to heavy metals
Russ. J. Genet.
43
825-828
2007
Nicotiana tabacum
-
Schuermann, J.P.; White, T.A.; Srivastava, D.; Karr, D.B.; Tanner, J.J.
Three crystal forms of the bifunctional enzyme proline utilization A (PutA) from Bradyrhizobium japonicum
Acta Crystallogr. Sect. F
64
949-953
2008
Bradyrhizobium japonicum (Q89E26)
Phang, J.M.; Donald, S.P.; Pandhare, J.; Liu, Y.
The metabolism of proline, a stress substrate, modulates carcinogenic pathways
Amino Acids
35
681-690
2008
Homo sapiens
Mitsubuchi, H.; Nakamura, K.; Matsumoto, S.; Endo, F.
Inborn errors of proline metabolism
J. Nutr.
138
2016S-2020S
2008
Homo sapiens (O43272)
Satomura, T.; Sakuraba, H.; Hara, Y.; Ohshima, T.
Crystallization and preliminary X-ray analysis of a novel dye-linked L-proline dehydrogenase from the aerobic hyperthermophilic archaeon Aeropyrum pernix
Acta Crystallogr. Sect. F
66
1508-1510
2010
Aeropyrum pernix (Q9YCJ0)
Funck, D.; Eckard, S.; Mueller, G.
Non-redundant functions of two proline dehydrogenase isoforms in Arabidopsis
BMC Plant Biol.
10
70
2010
Arabidopsis thaliana (Q6NKX1)
Mohammadi, H.; Omidinia, E.
Proline dehydrogenase from Pseudomonas fluorescens: Gene cloning, purification, characterization and homology modeling
Appl. Biochem. Microbiol.
48
167-174
2012
Pseudomonas fluorescens, Pseudomonas fluorescens Pf-5
Satomura, T.; Zhang, X.D.; Hara, Y.; Doi, K.; Sakuraba, H.; Ohshima, T.
Characterization of a novel dye-linked L-proline dehydrogenase from an aerobic hyperthermophilic archaeon, Pyrobaculum calidifontis
Appl. Microbiol. Biotechnol.
89
1075-1082
2011
Pyrobaculum calidifontis, Pyrobaculum calidifontis JCM 11548
Kawakami, R.; Noguchi, C.; Higashi, M.; Sakuraba, H.; Ohshima, T.
Comparative analysis of the catalytic components in the archaeal dye-linked L-proline dehydrogenase complexes
Appl. Microbiol. Biotechnol.
97
3419-3427
2013
Pyrococcus furiosus, Pyrococcus horikoshii, Pyrococcus horikoshii OT-3, Thermococcus kodakarensis, Thermococcus kodakarensis KOD1 JCM 12380, Thermococcus profundus (Q76M73), Thermococcus profundus DSM 9503 (Q76M73)
Luo, M.; Arentson, B.W.; Srivastava, D.; Becker, D.F.; Tanner, J.J.
Crystal structures and kinetics of monofunctional proline dehydrogenase provide insight into substrate recognition and conformational changes associated with flavin reduction and product release
Biochemistry
51
10099-10108
2012
Deinococcus radiodurans (Q9RW55)
Omidinia, E.; Mahdizadehdehosta, R.; Mohammadi, H.
Expression, purification and characterization of the proline dehydrogenase domain of PutA from Pseudomonas putida POS-F84
Indian J. Microbiol.
53
297-302
2013
Pseudomonas putida, Pseudomonas putida POS-F84
Sakuraba, H.; Satomura, T.; Kawakami, R.; Kim, K.; Hara, Y.; Yoneda, K.; Ohshima, T.
Crystal structure of novel dye-linked L-proline dehydrogenase from hyperthermophilic archaeon Aeropyrum pernix
J. Biol. Chem.
287
20070-20080
2012
Aeropyrum pernix
Mohammadi, H.S.; Omidinia, E.
Process integration for the recovery and purification of recombinant Pseudomonas fluorescens proline dehydrogenase using aqueous two-phase systems
J. Chromatogr. B
929
11-17
2013
Pseudomonas fluorescens
Cecchini, N.M.; Monteoliva, M.I.; Alvarez, M.E.
Proline dehydrogenase contributes to pathogen defense in Arabidopsis
Plant Physiol.
155
1947-1959
2011
Arabidopsis thaliana
Tallarita, E.; Pollegioni, L.; Servi, S.; Molla, G.
Expression in Escherichia coli of the catalytic domain of human proline oxidase
Protein Expr. Purif.
82
345-351
2012
Homo sapiens
Satomura, T.; Hara, Y.; Suye, S.; Sakuraba, H.; Ohshima, T.
Gene expression and characterization of a third type of dye-linked L-proline dehydrogenase from the aerobic hyperthermophilic archaeon, Aeropyrum pernix
Biosci. Biotechnol. Biochem.
76
589-593
2012
Aeropyrum pernix
Serrano, H.; Blanchard, J.S.
Kinetic and isotopic characterization of L-proline dehydrogenase from Mycobacterium tuberculosis
Biochemistry
52
5009-5015
2013
Mycobacterium tuberculosis (O50444), Mycobacterium tuberculosis H37Rv (O50444)
Monteoliva, M.I.; Rizzi, Y.S.; Cecchini, N.M.; Hajirezaei, M.R.; Alvarez, M.E.
Context of action of proline dehydrogenase (ProDH) in the hypersensitive response of Arabidopsis
BMC Plant Biol.
14
21
2014
Arabidopsis thaliana
Mohammadi, H.S.; Omidinia, E.
Process integration for the recovery and purification of recombinant Pseudomonas fluorescens proline dehydrogenase using aqueous two-phase systems
J. Chromatogr. B
929
11-17
2013
Pseudomonas fluorescens
Huijbers, M.; van Berkel, W.
A more polar N-terminal helix releases MBP-tagged Thermus thermophilus proline dehydrogenase from tetramer-polymer self-association
J. Mol. Catal. B
134
340-346
2016
Thermus thermophilus (Q72IB8)
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