1.6.1.2: NAD(P)+ transhydrogenase (Re/Si-specific) This is an abbreviated version! For detailed information about NAD(P)+ transhydrogenase (Re/Si-specific), go to the full flat file .
Reaction
NADPH +
NAD+ =
NADP+ +
NADH
Synonyms dII, dIII, energy-linked transhydrogenase, energy-linked, mitochondrial transhydrogenase, H+-thase, mitochondrial transhydrogenase, NAD transhydrogenase, NAD(P) transhydrogenase, NADH transhydrogenase, NADH-NADP-transhydrogenase, NADPH transhydrogenase, NADPH-NAD oxidoreductase, NADPH-NAD transhydrogenase, NADPH:NAD+ transhydrogenase, nicotinamide adenine dinucleotide (phosphate) transhydrogenase, nicotinamide nucleotide transhydrogenase, NNT, PNT, PntAB, proton-translocating nicotinamide nucleotide transhydrogenase, proton-translocating transhydrogenase, pyridine nucleotide transferase, pyridine nucleotide transhydrogenase, reversible mitochondrial membrane-associated transhydrogenase, transhydrogenase, transhydrogenase, nicotinamide adenine dinucleotide (phosphate)
ECTree
Source Tissue
Source Tissue on EC 1.6.1.2 - NAD(P)+ transhydrogenase (Re/Si-specific)
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very strong expression
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392595 , 392597 , 392601 , 392606 , 392607 , 392608 , 392611 , 392614 , 392615 , 392616 , 392617 , 392620 , 392621 , 392622 , 392623 , 392625 , 392626 , 392628 , 392629 , 392630 , 392631 , 392632 , 392633 , 392634 , 392635 , 392636 , 392637 , 392640 , 392642 , 392644 , 392646 , 392655 brenda
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highest expression level
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high expression level
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high expression level
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high expression level
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high expression level
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bone marrow-derived, Nnt mRNA and protein are expressed in resting macrophages and down-regulated in response to inflammatory stimuli such as lipopolysaccharide. Nnt mRNA and protein expression are further repressed in fully activated macrophages
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bone marrow-derived, Nnt mRNA and protein are expressed in resting macrophages and down-regulated in response to inflammatory stimuli such as lipopolysaccharide. Nnt mRNA and protein expression are repressed in fully activated macrophages
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from fifth larval instar
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insulin hypersecretion is associated with increased Nnt expression. It can be suggested that nicotinamide nucleotide transhydrogenase must play an important role in beta cell function
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additional information
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no or low activity in brain, prostate, seminal vesicle, spleen, testis
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additional information
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ubiquitous enzyme present in virtually all animal tissues
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additional information
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quantitative PCR protein expression analysis
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