1.6.2.4: NADPH-hemoprotein reductase
This is an abbreviated version!
For detailed information about NADPH-hemoprotein reductase, go to the full flat file.
Word Map on EC 1.6.2.4
-
1.6.2.4
-
monooxygenase
-
heme
-
quinone
-
xenobiotics
-
fmn
-
1.6.99.2
-
flavoproteins
-
dt-diaphorase
-
phenobarbital
-
cyp3a4
-
benzoapyrene
-
nadph:quinone
-
one-electron
-
drug-metabolizing
-
bioreductive
-
7-ethoxycoumarin
-
semiquinone
-
benzphetamine
-
two-electron
-
nadh-cytochrome
-
aminopyrine
-
cyp2c9
-
21-hydroxylase
-
n-demethylase
-
o-deethylation
-
phenobarbital-induced
-
p-450-dependent
-
3-methylcholanthrene
-
androstenedione
-
adrenodoxin
-
dicoumarol
-
7-ethoxyresorufin
-
ethylmorphine
-
phenobarbital-treated
-
beta-naphthoflavone
-
mixed-function
-
p-nitroanisole
-
p450-mediated
-
nitroreduction
-
p450-catalyzed
-
7,8-benzoflavone
-
omega-hydroxylation
-
cyp21a2
-
chlorzoxazone
-
o-dealkylation
-
virilization
-
17alpha-hydroxylase
-
6beta-hydroxylation
-
biotechnology
-
medicine
-
bufuralol
-
2-amino-3-methylimidazo4,5-fquinoline
- 1.6.2.4
- monooxygenase
- heme
- quinone
- xenobiotics
- fmn
-
1.6.99.2
- flavoproteins
- dt-diaphorase
- phenobarbital
- cyp3a4
-
benzoapyrene
-
nadph:quinone
-
one-electron
-
drug-metabolizing
-
bioreductive
- 7-ethoxycoumarin
- semiquinone
- benzphetamine
-
two-electron
-
nadh-cytochrome
- aminopyrine
- cyp2c9
- 21-hydroxylase
- n-demethylase
-
o-deethylation
-
phenobarbital-induced
-
p-450-dependent
- 3-methylcholanthrene
- androstenedione
- adrenodoxin
- dicoumarol
- 7-ethoxyresorufin
- ethylmorphine
-
phenobarbital-treated
- beta-naphthoflavone
-
mixed-function
-
p-nitroanisole
-
p450-mediated
-
nitroreduction
-
p450-catalyzed
- 7,8-benzoflavone
-
omega-hydroxylation
- cyp21a2
- chlorzoxazone
-
o-dealkylation
-
virilization
- 17alpha-hydroxylase
-
6beta-hydroxylation
- biotechnology
- medicine
- bufuralol
-
2-amino-3-methylimidazo4,5-fquinoline
Reaction
Synonyms
107366505, aldehyde reductase (NADPH-dependent), ATR2, CPR, CPR I, CPR-X1, CPR-X2, CPR1, CPR2, CYPOR, cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent), cytochrome P450 NADPH reductase, cytochrome P450 oxidoreductase, cytochrome P450 reductase, cytochrome P450-diflavin reductase, dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase, FAD-cytochrome c reductase, ferrihemprotein P450 reductase, flavocytochrome P450 BM3, NAD(P)H cytochrome P450 reductase, NADP-cytochrome c reductase, NADP-cytochrome P-450 reductase, NADP-cytochrome reductase, NADPH cytochrome P450 reductase, NADPH dependent cytochrome P450 reductase, NADPH P450 oxidoreductase, NADPH P450 reductase, NADPH-CPR, NADPH-CYP reductase, NADPH-CYP450 reductase, NADPH-cytochrome c oxidoreductase, NADPH-cytochrome c reductase, NADPH-cytochrome p-450 reductase, NADPH-cytochrome P450 (CYP) oxidoreductase, NADPH-cytochrome P450 oxidoreductase, NADPH-cytochrome P450 reductase, NADPH-cytochrome P450 reductase 2, NADPH-dependent cytochrome c reductase, NADPH-dependent cytochrome P450 reductase, NADPH-dependent P450 reductase, NADPH-ferricytochrome c oxidoreductase, NADPH-ferrihemoprotein reductase, NADPH-P450 reductase, NADPH: cytochrome P450 oxidoreductase, NADPH: cytochrome P450 reductase, NADPH:CYP oxidoreductase, NADPH:cytochrome P450 oxidoreductase, NADPH:cytochrome P450 reductase, NADPH:ferrihemoprotein oxidoreductase, NCP1, neotetrazolin reductase, NPR, NP_000932, P-450 reductase, P450 BM3, P450 oxidoreductase, P450 Red, P450 reductase, P450R, P450REd, POR, RedA, reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase, reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate), SbCPR2, TcCPR-A, TcCPR-B, TcCPR-C, TPNH-cytochrome c reductase, TPNH2 cytochrome c reductase, WsCPR1, WsCPR2
ECTree
1.6.2.4 NADPH-hemoprotein reductaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 1.6.2.4 - NADPH-hemoprotein reductase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone + NADPH
NADP+ + ?
-
i.e. RH1, the enzyme reduces the antitumor drug RH1 to a semiquinone free radical. Following this reduction RH1 undergoes redox cycling under oxic conditions to produce potentially damaging hydroxyl radicals
-
-
?
2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
-
-
-
-
?
2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
Coleus scutellarioides
-
-
-
-
?
2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
-
-
-
-
?
2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
-
-
-
-
?
2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
-
NADPH-cytochrome P450 reductase is a unique universal donor of electrons to practically all known microsomal cytochrome P450s and one of the most important components of the monooxygenase system
-
-
?
2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
-
-
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
-
involved in drug metabolism
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
-
-
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
-
-
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
-
component of the cytochrome P450 dependent monooxygenase system
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
-
-
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
-
-
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
-
-
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
-
-
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
Coleus scutellarioides
-
-
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
Corbula caribea
-
component of the mixed function oxygenase system
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
-
-
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
-
-
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
-
-
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
-
-
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
-
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
-
involved in drug metabolism
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
-
involved in drug metabolism, reduced cytochrome P450 is essential for drug metabolism
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
-
-
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
-
involved in drug metabolism, NADPH-cytochrome P450 deletion mouse is resistant to acetaminophen concentrations at doses toxic for normal mice
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
-
-
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
-
component of the cytochrome P450 dependent monooxygenase system
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
-
-
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
-
-
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
-
transfer of electrons during the CYP catalytic cycle
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
-
-
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
-
-
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
-
-
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
-
-
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
-
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
-
involved in the hydroxylation of progesterone at the 11alpha position
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
-
-
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
-
-
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
-
-
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
-
-
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
involved in activation of cytochrome P450 monooxygenase systems
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
involved in activation of cytochrome P450 monooxygenase systems
-
-
?
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
-
-
-
-
?
NADPH + ferricytochrome P450
ferrocytochrome P450 + NADP+
-
part of the microsomal electron-transport chains and responsible for the transfer of reducing equivalents between NADPH or NADH and cytochrome P-450
-
-
?
NADPH + ferricytochrome P450
ferrocytochrome P450 + NADP+
-
component of the hydroxylation of lauric acid
-
-
?
NADPH + ferricytochrome P450
ferrocytochrome P450 + NADP+
-
during hydroxylation of alkanes
-
-
?
NADPH + ferricytochrome P450
ferrocytochrome P450 + NADP+
-
part of the microsomal electron-transport chains and responsible for the transfer of reducing equivalents between NADPH or NADH and cytochrome P-450
-
-
?
NADPH + ferricytochrome P450
ferrocytochrome P450 + NADP+
-
-
-
-
?
NADPH + ferricytochrome P450
ferrocytochrome P450 + NADP+
-
during ecdysone hydroxylation
-
-
?
NADPH + ferricytochrome P450
ferrocytochrome P450 + NADP+
-
during hydroxylation of fatty acids through the bacterial fusion protein P450BM3
-
-
?
NADPH + H+ + cytochrome c
NADP+ + reduced cytochrome c
-
-
-
?
NADPH + H+ + n oxidized hemoprotein
NADP+ + n reduced hemoprotein
-
-
-
-
?
NADPH + H+ + n oxidized hemoprotein
NADP+ + n reduced hemoprotein
-
-
-
?
additional information
?
-
-
monooxygenase system only present in cells grown on alkanes
-
-
?
additional information
?
-
-
monooxygenase system composed of cytochrome P-450, NADPH-cytochrome c reductase, phospholipids
-
-
?
additional information
?
-
-
monooxygenase system composed of cytochrome P450, cytochrome b5 and NADPH cytochrome c P450 reductase
-
-
?
additional information
?
-
-
disruption of redA leads to mutant cells that form yellow mounds that fail to make proper fruiting bodies. The developmental arrest shown by this mutant implicates redA-encoded P450 oxidoreductase in the metabolism of compounds that control cell differentiation
-
-
?
additional information
?
-
-
CYP3A related metabolism in horse is dependent on the expression of the enzyme and also on adequate levels of NADPH P450 reductase and cytochrome b5
-
-
?
additional information
?
-
-
electron transport system composed of cytochrome P-450, cytochrome b5-like hemeproteins, NADPH cytochrome c reductase, and NADH-ferricyanide reductase
-
-
?
additional information
?
-
-
P450 Red does not contribute to the activation of RH1 (i.e. 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone) in cells with normal P450 Red activity and plays only a minor role in activating this agent in cells with high levels of this enzyme
-
-
?
additional information
?
-
-
CYPOR is involved in reduction of the prodrug PR-104A
-
-
?
additional information
?
-
-
functional assays studying the effects of specific POR mutations on steroidogenesis shows that several POR variants impair CYP17A1, CYP21A2 and CYP19A1 activities to different degrees
-
-
?
additional information
?
-
-
P450R function is essential for cytochrome P450 activity. The enzyme provides the electrons used in P450-mediated reactions using NADPH as a cofactor. P450R-transfected MDA 231 breast cells display increased sensitivity to mitomycin C and 5-fluorouracil as compared to their empty-vector transfected counterparts. NADPH levels are decreased in P450R-overexpressing cells
-
-
?
additional information
?
-
-
the bioreductive agent RH1 can be reduced by the enzyme. RH1 produces DNA strand breaks and crosslinks in isolated DNA after reduction by P450 Red. P450 Red does not play a significant role in activating RH1 in cells with normal P450 Red activity
-
-
?
additional information
?
-
-
the enzyme donates electrons derived from NADPH to a variety of acceptor proteins, including squalene monooxygenase, 7-dehydro-cholesterol reductase, heme oxygenase, cytochrome b5 , and many microsomal cytochromes P450
-
-
?
additional information
?
-
-
binding of cytochrome P450 2B4 to cytochrome b5 and cytochrome P450 reductase, binding site on cytochrome P450 2B4 for its redox partners, complex formation modelling, overview
-
-
?
additional information
?
-
-
monooxygenase system composed of ecdysone 20-monooxygenase, cytochrome P-450 and NADPH-cytochrome c reductase
-
-
?
additional information
?
-
-
acts as an electron transfer component of the alkane monoxygenase system
-
-
?
additional information
?
-
-
acts as an electron transfer component of the alkane monoxygenase system
-
-
?
additional information
?
-
-
component of the microsomal electron transport system
-
-
?
additional information
?
-
-
CPR, the obligate electron donor for microsomal P450 enzymes, is essential for the bioactivation of many procarcinogens
-
-
?
additional information
?
-
-
deletion of the NADPH-cytochrome P450 reductase gene in cardiomyocytes does not protect mice against doxorubicin-mediated acute cardiac toxicity
-
-
?
additional information
?
-
-
major effect of POR is on ellipticine detoxication (formation of 9-hydroxyellipticine by microsomal CYPs), and less on its oxidative activation to 12-hydroxy and 13-hydroxyellipticine
-
-
?
additional information
?
-
-
component of the microsomal electron transport system
-
-
?
additional information
?
-
-
mixed function oxidase system composed of cytochrome P-450, NADPH-cytochrome c reductase and phospholipids, biotransformation of airborne compounds
-
-
?
additional information
?
-
-
part of the bacterial fusion protein P450BM3 composed of cytochrome P450 fatty acid hydroxylase and NADPH cytochrome P450 reductase
-
-
?
additional information
?
-
-
detoxification of drugs, inactivation of procarcinogens
-
-
?
additional information
?
-
-
monooxygenase system composed of cytochrome P-450, NADPH-cytochrome c reductase, phospholipids
-
-
?
additional information
?
-
-
microsomal heme oxygenase system composed of heme oxygenase and NADPH-cytochrome c reductase catalyzes the oxidative degradation of heme to biliverdin, essential role in the physiological heme catabolism
-
-
?
additional information
?
-
-
the C-terminal 23 amino acids of heme oxygenase-1 play an important role in the interaction between heme oxygenase-1 and NADPH cytochrome P450 reductase, enhancing the conversion of hemin to biliverdin
-
-
?
additional information
?
-
the presence of NADPH-cytochrome P450 reductase prevents heme oxygenase-1 from acetylation of lysine residues, Lys149 and Lys153, located in the F-helix. The heme degradation activity of the fully acetylated heme oxygenase-1 in the NADPH/NADPH-cytochrome P450 reductase-supported system is significantly reduced, whereas almost no inactivation is detected in heme oxygenase-1 in the presence of NADPH-cytochrome P450 reductase, which prevents acetylation of Lys149 and Lys153
-
-
?
additional information
?
-
-
detoxification of drugs, inactivation of procarcinogens
-
-
?
additional information
?
-
-
monooxygenase system composed of cytochrome P-450, NADPH-cytochrome c reductase, phospholipids
-
-
?
additional information
?
-
-
microsomal electron transport system composed of cytochrome b5, cytochrome P450, NADH-cytochrome b5 reductase and NADPH-cytochrome c reductase
-
-
?
additional information
?
-
-
microsomal electron transport system composed of cytochrome b5, cytochrome P450, NADH-cytochrome b5 reductase and NADPH-cytochrome c reductase
-
-
?
additional information
?
-
-
microsomal electron transport system composed of cytochrome b5, cytochrome P450, NADH-cytochrome b5 reductase and NADPH-cytochrome c reductase
-
-
?
additional information
?
-
-
involved in the sterol biosynthesis pathways
-
-
?
additional information
?
-
-
involved in the sterol biosynthesis pathways
-
-
?
additional information
?
-
-
mixed-function oxidase system composed of cytochrome P450, NADPH cytochrome P450 reductase and lipid
-
-
?
additional information
?
-
cytochrome P450 monooxygenase gets reducing equivalents from NADPH cytochrome P450 reductase
-
-
?
additional information
?
-
-
cytochrome P450 monooxygenase gets reducing equivalents from NADPH cytochrome P450 reductase
-
-
?
additional information
?
-
-
microsomal heme oxygenase system composed of heme oxygenase and NADPH-cytochrome c reductase catalyzes the oxidative degradation of heme to biliverdin, essential role in the physiological heme catabolism
-
-
?
