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1.6.3.4: NADH oxidase (H2O-forming)

This is an abbreviated version!
For detailed information about NADH oxidase (H2O-forming), go to the full flat file.

Reaction

2 NADH + 2 H+ +

O2
= 2 NAD+ + 2 H2O

Synonyms

H2O-forming NADH oxidase, LrNox, NADH oxidase, nicotinamide adenine dinucleotide oxidase, NOX, Nox-2, NoxA, NoxE, SpNox, water-forming NADH oxidase, YODC

ECTree

     1 Oxidoreductases
         1.6 Acting on NADH or NADPH
             1.6.3 With oxygen as acceptor
                1.6.3.4 NADH oxidase (H2O-forming)

Inhibitors

Inhibitors on EC 1.6.3.4 - NADH oxidase (H2O-forming)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ascorbate
1 mM, 45% inhibition
Ca2+
0.1 mM, about 20% inhibition
Cr2+
0.1 mM, 92% inhibition
FAD
-
optimum FAD concentration for the LrNox is 0.01 mM, with 90% and 3% of maximum activity at 0.001 mM and 0.5 mM FAD, respectively. Enzyme activity decreases sharply with an increase in FAD concentration due to inhibition by FAD. More than 90% enzyme activity is lost when FAD concentration is increased from 0.01 to 0.3 mM
iodoacetate
Li+
-
1 mM, 80% residual activity
Mg2+
-
1 mM, 85% residual activity
Mn2+
0.1 mM, about 20% inhibition
Ni2+
-
1 mM, 72% residual activity
p-chloromercuribenzoate
quinacrin
strong inhibition
Quinine
Sn2+
0.1 mM, complete inhibition
Triton X-100
-
-
additional information
no significant inhibition at 0.1 mM, Ba2+, Ni2+, Fe2+ and Zn2+. Cysteine (1 mM), 1% inhibition
-