1.6.99.1: NADPH dehydrogenase
This is an abbreviated version!
For detailed information about NADPH dehydrogenase, go to the full flat file.
Word Map on EC 1.6.99.1
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1.6.99.1
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endothelial
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l-name
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artery
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l-arginine
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nerve
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ng-nitro-l-arginine
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vasodilation
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vessel
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nnos
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lipopolysaccharide
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hypertension
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cardiovascular
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acetylcholine
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agonist
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cerebral
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nitrite
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cyclase
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nitroprusside
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endothelium-dependent
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coronary
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contractile
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aorta
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cgmp
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tone
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histochemistry
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ischemia
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cyclooxygenase
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dimethylarginine
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ng-monomethyl-l-arginine
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guanylate
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nomega-nitro-l-arginine
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indomethacin
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nmda
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ganglion
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innervation
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vasoactive
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guanylyl
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peroxynitrite
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vasoconstriction
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aminoguanidine
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phenylephrine
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vasorelaxation
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endothelium-derived
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myenteric
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cholinergic
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n-methyl-d-aspartate
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tetrahydrobiopterin
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erectile
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bh4
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precontracted
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analysis
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synthesis
- 1.6.99.1
- endothelial
-
l-name
- artery
- l-arginine
- nerve
- ng-nitro-l-arginine
-
vasodilation
- vessel
- nnos
- lipopolysaccharide
- hypertension
- cardiovascular
- acetylcholine
- agonist
- cerebral
- nitrite
- cyclase
- nitroprusside
-
endothelium-dependent
- coronary
-
contractile
- aorta
- cgmp
-
tone
-
histochemistry
- ischemia
-
cyclooxygenase
- dimethylarginine
- ng-monomethyl-l-arginine
-
guanylate
- nomega-nitro-l-arginine
- indomethacin
- nmda
- ganglion
-
innervation
-
vasoactive
-
guanylyl
- peroxynitrite
-
vasoconstriction
- aminoguanidine
- phenylephrine
-
vasorelaxation
-
endothelium-derived
- myenteric
-
cholinergic
- n-methyl-d-aspartate
- tetrahydrobiopterin
-
erectile
- bh4
-
precontracted
- analysis
- synthesis
Reaction
Synonyms
2-cyclohexen-1-one, dehydrogenase, reduced nicotinamide adenine dinucleotide phosphate, diaphorase, dihydronicotinamide adenine dinucleotide phosphate dehydrogenase, EBP, Estrogen-binding protein, NADP-d, NADPH diaphorase, NADPH-d, NADPH-dehydrogenase, NADPH-dependent cyclohexenone reductase, NADPH-dependent diaphorase, NADPH-diaphorase, NADPH-methemoglobin reductase, NADPH2-dehydrogenase, NCR, nicotinamide adenine dinucleotide phosphate diaphorase, nitric oxide synthase, old yellow enzyme, Old yellow enzyme homolog, OYE, OYE1, OYE2, OYE3, reduced nicotinamide adenine dinucleotide phosphate dehydrogenase, SYE4, TPNH dehydrogenase, TPNH-diaphorase, triphosphopyridine diaphorase, triphosphopyridine nucleotide diaphorase, YqjM
ECTree
1.6.99.1 NADPH dehydrogenaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 1.6.99.1 - NADPH dehydrogenase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(E)-ethyl 2-methyl-4-oxopent-2-enoate + NADP+
ethyl (2R)-2-methyl-4-oxopentanoate + NADPH + H+
-
-
-
-
?
ketoisophorone + NADPH + H+
(6R)-levodione + NADP+
Candida macedoniensis
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i.e. 2,6,6-trimethyl-2-cyclohexen-1,4-dione
i.e.2,6,6-trimethylcycolhexane-1,4-dione
-
?
methyl 2-phenylacrylate + NADP+
methyl (2R)-2-methyl-3-phenylpropanoate + NADPH + H+
-
-
-
-
?
NADH + H+ + acceptor
NAD+ + reduced acceptor
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no activity with beta-NADH
-
-
?
NADPH + H+ + 2-cyclohexen-1-one
NADP+ + ?
-
the substrate results in a very rapid and strong reduction of SYE4
-
-
?
NADPH + H+ + NEM
NADP+ + ?
-
the substrate results in a very rapid and strong reduction of SYE4
-
-
?
NADPH + H+ + oxidized nitroblue tetrazolium hydrochloride
NADP+ + reduced nitroblue tetrazolium hydrochloride
-
-
-
-
r
NADPH + H+ + prostaglandin H2
NADP+ + prostaglandin F2alpha
-
via FMN cofactor, stereoselective reaction mechanism
-
-
?
(1-nitroprop-1-en-2-yl)benzene + NADP+
[(2S)-1-nitropropan-2-yl]benzene + NADPH + H+
-
-
-
-
?
(1-nitroprop-1-en-2-yl)benzene + NADP+
[(2S)-1-nitropropan-2-yl]benzene + NADPH + H+
-
-
-
-
?
(E)-(2-nitroprop-1-en-1-yl)benzene + NADP+
[(3S)-3-nitrobutyl]benzene + NADPH + H+
-
-
-
-
?
(E)-(2-nitroprop-1-en-1-yl)benzene + NADP+
[(3S)-3-nitrobutyl]benzene + NADPH + H+
-
-
-
-
?
NADPH + acceptor
NADP+ + reduced acceptor
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acceptor: nitroblue tetrazolium hydrochloride
-
-
?
NADPH + acceptor
NADP+ + reduced acceptor
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the enzyme is transiently activated by pheromone
-
-
?
NADPH + acceptor
NADP+ + reduced acceptor
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diaphorase activity of neuron somata shows no activity with alpha-NADPH
-
-
?
NADPH + acceptor
NADP+ + reduced acceptor
-
acceptor: nitroblue tetrazolium hydrochloride
-
-
?
NADPH + acceptor
NADP+ + reduced acceptor
-
intracerebral hemorrhage in the internal capsule may induce NADPH-diaphorase activity
-
-
?
NADPH + acceptor
NADP+ + reduced acceptor
-
-
-
-
?
NADPH + acceptor
NADP+ + reduced acceptor
-
acceptor: 2-cyclohexenone
-
-
?
NADPH + acceptor
NADP+ + reduced acceptor
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both alpha-NADPH and beta-NADPH are capable of reducing the enzyme. alpha-NADPH is more effective
-
-
?
NADPH + acceptor
NADP+ + reduced acceptor
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physiological role as electron transfer component
-
-
?
NADPH + acceptor
NADP+ + reduced acceptor
-
acceptor: nitroblue tetrazolium hydrochloride
-
-
?
NADPH + acceptor
NADP+ + reduced acceptor
-
nitroblue tetrazolium is reduced to formazan
-
-
?
NADPH + H+ + acceptor
NADP+ + reduced acceptor
-
the one-electron transfer from OYE proceeds more smoothly than the two-electron transfer from OYE. The physiological electron acceptors may be cytochrome b5 or a b5-like protein
-
-
?
NADPH + H+ + acrolein
NADP+ + propionaldehyde
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OYE2 protects against acrolin toxicity, the product propionaldehyde is not toxic. OYE2 is required for basal level of tolerance
-
-
?
NADPH + H+ + acrolein
NADP+ + propionaldehyde
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OYE3 protects against acrolin toxicity, the product propionaldehyde is not toxic. OYE3 expression is particularly induced following acrolein stress
-
-
?
NADPH + H+ + acrolein
NADP+ + propionaldehyde
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the substrate results in a very rapid and strong reduction of SYE4
-
-
?
NADPH + H+ + nitroglycerin
NADP+ + ?
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the substrate results in a very rapid and strong reduction of SYE4
-
-
?
additional information
?
-
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involved in detoxification and oxidative stress response
-
-
?
additional information
?
-
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OYE3 interferes with Bax- and H2O2-induced lipid peroxidation and cell death in Saccharomyces cerevisiae
-
-
?
additional information
?
-
the photoinduced electron transfer is compared in the structurally homologous enzymes 12-oxophytodienoate reductase 1 (OPR1) and Old Yellow Enzyme 1 (OYE1). The inside of a protein active site is a complex/heterogeneous dielectric network where genetically programmed heterogeneity near the site of biological electron transfer can significantly affect the presence and lifetime of various intermediate states
-
-
-
additional information
?
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analysis of binding mode of beta-lapachone, a trypanocidal agent, and other naphthoquinones by molecular docking and dynamics: their binding to TcOYE is stabilized mainly by interactions with the isoalloxazine ring from FMN and residues from the active-site pocket
-
-
?
additional information
?
-
-
old yellow enzyme is an NADPH oxidoreductase capable of reducing a variety of compounds, it catalyzes one- or two-electron reduction
-
-
?
