1.7.1.7: GMP reductase
This is an abbreviated version!
For detailed information about GMP reductase, go to the full flat file.
Word Map on EC 1.7.1.7
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1.7.1.7
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purine
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imp
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salvage
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hypoxanthine
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impdhs
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hypoxanthine-guanine
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adenylosuccinate
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medicine
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drug development
- 1.7.1.7
- purine
- imp
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salvage
- hypoxanthine
- impdhs
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hypoxanthine-guanine
- adenylosuccinate
- medicine
- drug development
Reaction
Synonyms
EC 1.6.6.8, GMPR, GMPR-I, GMPR-II, GMPR2, guaC, Guanosine 5'-monophosphate oxidoreductase, guanosine 5'-monophosphate reductase, guanosine monophosphate reductase, guanosine monophosphate reductase 2, guanosine-5'-monophosphate reductase, guanylate reductase, HsGMPR1, HsGMPR2, LmGMPR, Lmj17.0725, LMJF_17_0725, NADPH:GMP oxidoreductase (deaminating), reductase, guanylate, Tb927.5.2080, TbGMPR, TcGMPR, TCIL3000_5_1940
ECTree
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Substrates Products
Substrates Products on EC 1.7.1.7 - GMP reductase
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REACTION DIAGRAM
NADPH + H+ + guanosine 5'-phosphate
NADP+ + inosine 5'-phosphate + NH3
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?
additional information
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enzyme nucleotide bindng analysis, nucleotide binding alters the quarternary structure of the enzyme, overview
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?
GMP + NADPH + H+
IMP + NH3 + NADP+
reductive deamination of GMP, the back conversion of IMP to GMP is highly unfavorable
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?
NADP+ + inosine 5'-phosphate + NH3
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-
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?
NADPH + guanosine 5'-phosphate
NADP+ + inosine 5'-phosphate + NH3
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the rate of the reverse reaction is 6% of the forward reaction
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r
NADPH + guanosine 5'-phosphate
NADP+ + inosine 5'-phosphate + NH3
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-
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?
NADPH + guanosine 5'-phosphate
NADP+ + inosine 5'-phosphate + NH3
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involved in salvage pathway of purine synthesis
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?
NADPH + guanosine 5'-phosphate
NADP+ + inosine 5'-phosphate + NH3
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-
-
?
NADPH + guanosine 5'-phosphate
NADP+ + inosine 5'-phosphate + NH3
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-
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?
NADPH + guanosine 5'-phosphate
NADP+ + inosine 5'-phosphate + NH3
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GMP and IMP binding are thermodynamically favorable processes. Protonation and hydride transfer steps take place in the same transition state. Product release does not contribute to the rate-limiting step of the reaction
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?
NADPH + guanosine 5'-phosphate
NADP+ + inosine 5'-phosphate + NH3
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specific for GMP
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ir
NADPH + guanosine 5'-phosphate
NADP+ + inosine 5'-phosphate + NH3
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-
?
NADPH + guanosine 5'-phosphate
NADP+ + inosine 5'-phosphate + NH3
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-
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ir
NADPH + guanosine 5'-phosphate
NADP+ + inosine 5'-phosphate + NH3
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-
-
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ir
NADPH + guanosine 5'-phosphate
NADP+ + inosine 5'-phosphate + NH3
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-
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ir
NADPH + guanosine 5'-phosphate
NADP+ + inosine 5'-phosphate + NH3
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less than 10% of the NADPH rate: thionicotinamide-NADPH, deamino-NADPH, 3-acetylpyrimidine-NADPH
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?
NADPH + guanosine 5'-phosphate
NADP+ + inosine 5'-phosphate + NH3
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arabinosylGMP, 2'-dGMP and 8-azaGMP are reductively deaminated to their corresponding IMP analog at rates 1-2% the rate with GMP
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?
NADPH + guanosine 5'-phosphate
NADP+ + inosine 5'-phosphate + NH3
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essential for the salvage pathway of purine ribonucleotide biosynthesis
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ir
NADPH + guanosine 5'-phosphate
NADP+ + inosine 5'-phosphate + NH3
important for the maintenance of the intracellular adenine guanine balance, possible role in the regulation of differentiation of leukemia cells
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ir
NADPH + guanosine 5'-phosphate
NADP+ + inosine 5'-phosphate + NH3
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-
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?
NADPH + guanosine 5'-phosphate
NADP+ + inosine 5'-phosphate + NH3
-
specific for GMP
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ir
NADPH + guanosine 5'-phosphate
NADP+ + inosine 5'-phosphate + NH3
-
-
-
?
NADPH + guanosine 5'-phosphate
NADP+ + inosine 5'-phosphate + NH3
-
-
-
?
NADPH + guanosine 5'-phosphate
NADP+ + inosine 5'-phosphate + NH3
-
-
?
NADPH + guanosine 5'-phosphate
NADP+ + inosine 5'-phosphate + NH3
enzyme may play a role in brown fat response
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?
NADPH + guanosine 5'-phosphate
NADP+ + inosine 5'-phosphate + NH3
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-
-
?
NADPH + guanosine 5'-phosphate
NADP+ + inosine 5'-phosphate + NH3
-
-
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ir
NADPH + guanosine 5'-phosphate
NADP+ + inosine 5'-phosphate + NH3
-
specific for GMP
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ir
NADPH + guanosine 5'-phosphate
NADP+ + inosine 5'-phosphate + NH3
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enzyme is involved in interconversion of purine ribonucleotides
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ir