1.7.3.3: factor-independent urate hydroxylase
This is an abbreviated version!
For detailed information about factor-independent urate hydroxylase, go to the full flat file.
Word Map on EC 1.7.3.3
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1.7.3.3
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hyperuricemia
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peroxisomal
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xanthine
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allopurinol
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gout
-
purine
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catalase
-
allantoin
-
biosensors
-
electrode
-
hematologic
-
creatinine
-
oxonic
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febuxostat
-
allantoinase
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hyperkalemia
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hypoxanthine
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prophylaxis
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flavus
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hyperphosphatemia
-
urate-lowering
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ureide
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methemoglobinemia
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pegylated
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amperometric
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uricosuric
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hypocalcemia
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tophi
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benzbromarone
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hominoid
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phosphotungstate
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microbodies
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hypouricemic
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probenecid
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utilis
-
pimecrolimus
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pharmacology
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medicine
-
analysis
-
synthesis
-
weight-based
-
nodule-specific
-
miocene
-
drug development
- 1.7.3.3
- hyperuricemia
- peroxisomal
- xanthine
- allopurinol
- gout
- purine
- catalase
- allantoin
-
biosensors
-
electrode
-
hematologic
- creatinine
-
oxonic
- febuxostat
- allantoinase
- hyperkalemia
- hypoxanthine
-
prophylaxis
- flavus
- hyperphosphatemia
-
urate-lowering
-
ureide
- methemoglobinemia
-
pegylated
-
amperometric
-
uricosuric
-
hypocalcemia
-
tophi
- benzbromarone
-
hominoid
-
phosphotungstate
- microbodies
-
hypouricemic
- probenecid
- utilis
- pimecrolimus
- pharmacology
- medicine
- analysis
- synthesis
-
weight-based
-
nodule-specific
-
miocene
- drug development
Reaction
Synonyms
AaUO, AgUOX, dHU-wPU, ELITEK, Fasturtec, MVSM, N-35, Nodule specific uricase, Nodulin 35, Nodulin 35 homolog, Non-symbiotic uricase, oxidase, urate, Pucl, Rasburicase, Uaz, Uox, Urate oxidase, urate oxidoreductase, UriA, uric acid oxidase, uricase, uricase II, Uricoenzyme, Uricozyme
ECTree
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KM Value
KM Value on EC 1.7.3.3 - factor-independent urate hydroxylase
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0.0065
Urate
mutant H245L/E252A/M253I/R291K/A296V/A301S/K303R, pH 8.6, 25°C
0.017
Urate
mutant A89T/G91A7V92M/H245L/E252A/M253I/R291K/A296V/A301S/K303R, pH 8.6, 25°C
0.1045
Urate
mutant enzyme K12C/E286C, at pH 7.4, temperature not specified in the publication
0.1268
Urate
mutant enzyme S296C/C302S, at pH 7.4, temperature not specified in the publication
0.1403
Urate
wild type enzyme, at pH 7.4, temperature not specified in the publication
0.27
Urate
unmodified enzyme, 50 mM borate buffer, 25°C, pH 9.2
0.8
Urate
unmodified enzyme, 50 mM borate buffer, 40°C, pH 9.2
0.05
uric acid
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native uricase, monomethoxypoly(ethylene glycol) N-leucine-OSu-uricase and branched monomethoxypoly(ethylene glycol) N-leucine-OSu-uricase
0.25
uric acid
DQ887577
0.1 M sodium borate, pH 8.5 containing 2 mM uric acid, 30 mM 4-aminoantipyrine, 1.5% phenol and peroxidase (15 U/ml), 37°C, 20 min
additional information
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Km value for degradation of urate crystals is 7 microg/ml, 30°C, pH not specified in the publication
additional information
Urate
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Km value for degradation of urate crystals is 9 microg/ml, 30°C, pH not specified in the publication