1.8.1.12: trypanothione-disulfide reductase
This is an abbreviated version!
For detailed information about trypanothione-disulfide reductase, go to the full flat file.
Word Map on EC 1.8.1.12
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1.8.1.12
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trypanosoma
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leishmania
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cruzi
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chagas
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trypanosomatids
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leishmaniasis
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brucei
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trypanocidal
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antileishmanial
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donovani
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promastigotes
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trypanosomiasis
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infantum
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amastigotes
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fasciculata
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antitrypanosomal
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crithidia
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antiparasitic
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flavoenzyme
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phenothiazine
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medicine
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epimastigotes
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nifurtimox
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amazonensis
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antiprotozoal
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trypomastigotes
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tryparedoxin
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kinetoplastida
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leishmanicidal
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congolense
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rhodesiense
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miltefosine
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antimonial
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ts2
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n1,n8-bisglutathionylspermidine
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benznidazole
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clomipramine
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glutathionylspermidine
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antichagasic
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thioridazine
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ovothiols
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nitrofuran
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trypanothione-dependent
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pharmacology
- 1.8.1.12
- trypanosoma
- leishmania
- cruzi
- chagas
-
trypanosomatids
- leishmaniasis
- brucei
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trypanocidal
-
antileishmanial
- donovani
- promastigotes
- trypanosomiasis
- infantum
- amastigotes
- fasciculata
-
antitrypanosomal
- crithidia
-
antiparasitic
-
flavoenzyme
- phenothiazine
- medicine
- epimastigotes
- nifurtimox
- amazonensis
-
antiprotozoal
- trypomastigotes
- tryparedoxin
- kinetoplastida
-
leishmanicidal
- congolense
- rhodesiense
- miltefosine
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antimonial
- ts2
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n1,n8-bisglutathionylspermidine
- benznidazole
- clomipramine
- glutathionylspermidine
-
antichagasic
- thioridazine
-
ovothiols
-
nitrofuran
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trypanothione-dependent
- pharmacology
Reaction
Synonyms
EC 1.6.4.8, LbTryR, LdTryR, Li-TryR, LiTR, N(1),N(8)-bis(glutathionyl)spermidine reductase, NADPH2:trypanothione oxidoreductase, TbTR, TCDM_11669, TcTR, TPR, TR, trypanothione disulfide reductase, trypanothione reductase, trypanothione-disulfide reductase, TryR
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Application
Application on EC 1.8.1.12 - trypanothione-disulfide reductase
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medicine
pharmacology
additional information
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modeled structure of trypanothione reductase shows different active site from glutathione reductase, a specific inhibitor against trypanothione reductase can be designed without interfering with host glutathione reductase activity
medicine
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good target for structure/function studies and trypanicidal inhibitor design
medicine
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good target for structure/function studies and trypanicidal inhibitor design
medicine
good target for structure/function studies and trypanicidal inhibitor design
medicine
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potential target for drug design against trypanosomiasis
medicine
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potential target for drug design against trypanosomiasis
medicine
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target for rational approach to design new anti-leishmanial chemotherapeutic agents
medicine
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nitrofuran derivatives show antiparasitic effect on the trypanocidal drug design target trypanothione reductase
medicine
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inhibition of the enzyme by naphthoquinone and nitrofuran derivatives abolish the cell penetration by the parasite trypomasstigotes, alternate approach to chemotherapy of trypanosomiasis and leishmaniasis, Chagas' disease
medicine
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inhibition of the enzyme by naphthoquinone and nitrofuran derivatives abolish the cell penetration by the parasite trypomasstigotes, alternate approach to chemotherapy of trypanosomiasis and leishmaniasis, Chagas' disease
medicine
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enzyme substrate trypanothione disulfide is the primary target for arsenical drugs against african trypanosomes
medicine
enzyme is a target for development of antileishmanial drugs
medicine
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hypnophilin is good candidate for developing new drugs against Chagas disease
pharmacology
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trypanothione reductase plays a central role in the trypanosomatid parasites defense against oxidative stress, trypanothione reductase is a promising target for antitrypanosomal drugs, 2-iminobenzimidazole class are potent trypanothione reductase inhibitors against Trypanosoma brucei rhodesiense and low cytotoxicity against human cells
pharmacology
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trypanothione reductase plays a central role in the trypanosomatid parasites defense against oxidative stress, trypanothione reductase is a promising target for antitrypanosomal drugs, binding affinity towards trypanothione reductase and glutathione reductase of nitrofuran derivatives is assessed by standard molecular docking procedures and both, energy and structural output analysis, nitrofuran ligands display a slight preference to bind the closely related human glutathione reductase, they should not be considered as drugs with selective inhibition of trypanothione reductase
pharmacology
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trypanothione reductase plays a central role in the trypanosomatid parasites defense against oxidative stress, trypanothione reductase is a promising target for antitrypanosomal drugs, novel inhibitors are identified
pharmacology
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trypanothione reductase plays a central role in the trypanosomatid parasites defense against oxidative stress, trypanothione reductase is a promising target for antitrypanosomal drugs, synthesis of dethiotrypanothione and related trypanothione analogues featuring ring-closing olefin metathesis macrocyclizations is described