1.8.1.12: trypanothione-disulfide reductase
This is an abbreviated version!
For detailed information about trypanothione-disulfide reductase, go to the full flat file.
Word Map on EC 1.8.1.12
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1.8.1.12
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trypanosoma
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leishmania
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cruzi
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chagas
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trypanosomatids
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leishmaniasis
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brucei
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trypanocidal
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antileishmanial
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donovani
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promastigotes
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trypanosomiasis
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infantum
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amastigotes
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fasciculata
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antitrypanosomal
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crithidia
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antiparasitic
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flavoenzyme
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phenothiazine
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medicine
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epimastigotes
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nifurtimox
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amazonensis
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antiprotozoal
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trypomastigotes
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tryparedoxin
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kinetoplastida
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leishmanicidal
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congolense
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rhodesiense
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miltefosine
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antimonial
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ts2
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n1,n8-bisglutathionylspermidine
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benznidazole
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clomipramine
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glutathionylspermidine
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antichagasic
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thioridazine
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ovothiols
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nitrofuran
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trypanothione-dependent
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pharmacology
- 1.8.1.12
- trypanosoma
- leishmania
- cruzi
- chagas
-
trypanosomatids
- leishmaniasis
- brucei
-
trypanocidal
-
antileishmanial
- donovani
- promastigotes
- trypanosomiasis
- infantum
- amastigotes
- fasciculata
-
antitrypanosomal
- crithidia
-
antiparasitic
-
flavoenzyme
- phenothiazine
- medicine
- epimastigotes
- nifurtimox
- amazonensis
-
antiprotozoal
- trypomastigotes
- tryparedoxin
- kinetoplastida
-
leishmanicidal
- congolense
- rhodesiense
- miltefosine
-
antimonial
- ts2
-
n1,n8-bisglutathionylspermidine
- benznidazole
- clomipramine
- glutathionylspermidine
-
antichagasic
- thioridazine
-
ovothiols
-
nitrofuran
-
trypanothione-dependent
- pharmacology
Reaction
Synonyms
EC 1.6.4.8, LbTryR, LdTryR, Li-TryR, LiTR, N(1),N(8)-bis(glutathionyl)spermidine reductase, NADPH2:trypanothione oxidoreductase, TbTR, TCDM_11669, TcTR, TPR, TR, trypanothione disulfide reductase, trypanothione reductase, trypanothione-disulfide reductase, TryR
ECTree
1.8.1.12 trypanothione-disulfide reductaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 1.8.1.12 - trypanothione-disulfide reductase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
trypanothione disulfide + NADPH
trypanothione + NADP+
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protection against oxidative stress
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-
?
trypanothione disulfide + NADPH
trypanothione + NADP+
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scheme for trypanothione-dependent H2O2 metabolism
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?
trypanothione disulfide + NADPH
trypanothione + NADP+
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metabolizes H2O2, recombinant and wild-type cells
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?
trypanothione disulfide + NADPH
trypanothione + NADP+
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physiological function is to protect the organism from oxidative stress and to assist in maintaining low intracellular levels of hydrogen peroxide
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?
trypanothione disulfide + NADPH
trypanothione + NADP+
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highly specific for
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-
?
trypanothione disulfide + NADPH
trypanothione + NADP+
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kex enzyme in the tryanothione-based redox metabolism of pathogenic trypanosomes
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-
?
trypanothione disulfide + NADPH + H+
trypanothione + NADP+
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-
-
-
?
trypanothione disulfide + NADPH + H+
trypanothione + NADP+
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-
-
-
?
trypanothione disulfide + NADPH + H+
trypanothione + NADP+
-
-
-
-
?
trypanothione disulfide + NADPH + H+
trypanothione + NADP+
-
-
-
-
?
trypanothione disulfide + NADPH + H+
trypanothione + NADP+
-
-
-
?
trypanothione disulfide + NADPH + H+
trypanothione + NADP+
-
-
-
?
trypanothione disulfide + NADPH + H+
trypanothione + NADP+
-
-
-
ir
trypanothione disulfide + NADPH + H+
trypanothione + NADP+
-
-
-
-
?
trypanothione disulfide + NADPH + H+
trypanothione + NADP+
-
-
-
?
trypanothione disulfide + NADPH + H+
trypanothione + NADP+
-
-
-
?
trypanothione disulfide + NADPH + H+
trypanothione + NADP+
-
-
-
-
?
trypanothione disulfide + NADPH + H+
trypanothione + NADP+
-
-
-
-
?
trypanothione disulfide + NADPH + H+
trypanothione + NADP+
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-
-
-
?
additional information
?
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enzyme is associated with infective capacity of the parasite
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-
?
additional information
?
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enzyme is required for maintaining the reducing intracellular environment
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?
additional information
?
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enzyme is required for maintaining the reducing intracellular redox equilibrium, trypanosomes lacking the enzyme are avirulent and show increased sensitivity to oxidative stress
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?
