1.8.1.18: NAD(P)H sulfur oxidoreductase (CoA-dependent)

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For detailed information about NAD(P)H sulfur oxidoreductase (CoA-dependent), go to the full flat file.

Reaction

Synonyms

CoA-dependent NAD(P)H: elemental sulfur (S0) oxidoreductase, coenzyme A-dependent NADPH sulfur oxidoreductase, NAD(P)H-dependent sulfur reductase, NAD(P)H: S0 oxidoreductase, NADPH NSR, NSR, PF1186, S(0) reductase, TK1186, TK1299

ECTree

     1 Oxidoreductases

         1.8 Acting on a sulfur group of donors

             1.8.1 With NAD⁺ or NADP⁺ as acceptor

                1.8.1.18 NAD(P)H sulfur oxidoreductase (CoA-dependent)

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Results	in table
2	Activating Compound
4	AA Sequence
3	Cloned(Commentary)
11	Cofactor
2	Expression
1	General Information
4	KM Value [mM]
2	Localization
6	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
7	Organism
1	Oxidation Stability
3	Pathway
4	pH Optimum
3	Purification (Commentary)
1	Reaction
6	Reference
3	Specific Activity [micromol/min/mg]
9	Substrates and Products (Substrate)
4	Subunits
16	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]

Natural Substrates Products

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Natural Substrates Products on EC 1.8.1.18 - NAD(P)H sulfur oxidoreductase (CoA-dependent)

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

sulfur + NAD(P)H + H+

hydrogen sulfide + NAD(P)+

2 entries

sulfur + NAD(P)H + H+

hydrogen sulfide + NAD(P)+

Pyrococcus furiosus

Q8U1M0

the rate of sulfide production from colloidal sulfur is linear (up to 10 min) suggesting that this is the true substrate for the enzyme. A lag phase in sulfide production would be expected if polysulfide, which is generated by the reaction of sulfide with elemental sulfur, is the natural substrate. A less-than-twofold increase in activity is observed, both at pH 7.0 and at pH 9.0, when polysulfide (11 mM) is used as the substrate compared to when elemental sulfur (6.4 g/liter) is used. Polysulfide is stable at pH 8 and readily dissociates to colloidal sulfur and sulfide at neutral pH. A much greater stimulation of activity would be observed if polysulfide is the preferred substrate, particularly at the higher pH

722519

-

-

?

sulfur + NAD(P)H + H+

hydrogen sulfide + NAD(P)+

Thermococcus kodakarensis

Q5JGF8, Q5JGP4

a catalytic cycle of TK1299 is proposed suggesting that CoA-SH acts to solubilize S(0) by forming CoA persulfides, followed by reduction of an enzyme-S-S-CoA intermediate produced after both enzymatic and non-enzymatic evolution of H2S from the CoA persulfide, with NADPH as an electron donor

727447

-

-

?