1.8.1.2: assimilatory sulfite reductase (NADPH)
This is an abbreviated version!
For detailed information about assimilatory sulfite reductase (NADPH), go to the full flat file.
Word Map on EC 1.8.1.2
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1.8.1.2
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sulfur
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siroheme
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dissimilatory
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hemoprotein
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desulfovibrio
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sulfate-reducing
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thiosulfate
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six-electron
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desulfoviridin
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o-acetylserine
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sulfhydrylase
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dsrab
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sulfurylase
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5'-phosphosulfate
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hildenborough
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ferredoxin-dependent
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o-acetyl-l-serine
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exchange-coupled
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desulfotomaculum
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brewing
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nutrition
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medicine
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synthesis
- 1.8.1.2
- sulfur
- siroheme
-
dissimilatory
- hemoprotein
- desulfovibrio
-
sulfate-reducing
- thiosulfate
-
six-electron
-
desulfoviridin
- o-acetylserine
-
sulfhydrylase
- dsrab
-
sulfurylase
- 5'-phosphosulfate
- hildenborough
-
ferredoxin-dependent
- o-acetyl-l-serine
-
exchange-coupled
- desulfotomaculum
- brewing
- nutrition
- medicine
- synthesis
Reaction
+ 3 NADP+ + 3 H2O = + 3 NADPH + 3 H+
Synonyms
CNG03990, coenzyme F420-dependent sulfite reductase, CysI, CysIJ, desulforubidin, EC 1.8.99.1, Fsr, H2S-NADP oxidoreductase, MET10, NADPH-dependent assimilatory sulfite reductase, NADPH-dependent sulfite reductase, NADPH-sulfite reductase, reductase, sulfite (reduced nicotinamide adenine dinucleotide phosphate), SIR, SIR-FP, SIR-HP, SiR/SiRHP, SIRHP, sulfite reductase, sulfite reductase hemo-subunit
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Substrates Products
Substrates Products on EC 1.8.1.2 - assimilatory sulfite reductase (NADPH)
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REACTION DIAGRAM
1,1'-dimethyl-4,4'-bipyridinium dichloride + NADPH
NADPH + oxidized 1,1'-dimethyl-4,4'-bipyridinium dichloride
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i.e. paraquat, a herbicide
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-
?
hydrogen sulfide + 3 NADP+ + 3 H2O
sulfite + 3 NADPH + 3 H+
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-
-
-
?
NADP+ + reduced methyl viologen
NADPH + oxidized methyl viologen
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-
-
-
?
hydroxylamine + NADPH
ammonia + NADP+
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NADPH can be replaced by reduced methyl viologen
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?
nitrite + NADPH
ammonia + NADP+
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NADPH can be replaced by reduced methyl viologen, the latter reaction is catalyzed by hemoprotein subunit alone
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-
?
nitrite + NADPH
ammonia + NADP+
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-
-
-
?
sulfite + 3 NADPH + 3 H+
hydrogen sulfide + 3 NADP+ + 3 H2O
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-
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?
sulfite + 3 NADPH + 3 H+
hydrogen sulfide + 3 NADP+ + 3 H2O
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essential enzyme in the global sulfur cycle
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-
?
sulfite + 3 NADPH + 3 H+
hydrogen sulfide + 3 NADP+ + 3 H2O
the electron transfer occurs via multiple pathways, bypassing the need for electrons to move intra-molecularly from the NADH to the FAD to the FMN and then in cis to SiRHP. In this way, SiR effectively raises the local concentration of electrons relative to SiRHP active sites to facilitate the full six electron reduction of SO32- to S2-
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-
?
sulfite + 3 NADPH + 3 H+
hydrogen sulfide + 3 NADP+ + 3 H2O
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-
-
?
sulfite + NADPH
sulfide + NADP+ + H2O
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reduction of sulfite by reduced methyl viologen is catalyzed by hemoprotein subunit alone
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-
?
sulfite + NADPH
sulfide + NADP+ + H2O
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NADPH can be replaced by reduced methyl viologen
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-
?
sulfite + NADPH
sulfide + NADP+ + H2O
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NADPH can be replaced by reduced methyl viologen
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?
sulfite + NADPH
sulfide + NADP+ + H2O
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reduction of sulfite by reduced methyl viologen is catalyzed by hemoprotein subunit alone
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-
?
sulfite + NADPH
sulfide + NADP+ + H2O
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NADPH can be replaced by reduced methyl viologen
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-
?
sulfite + NADPH
sulfide + NADP+ + H2O
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-
-
-
?
sulfite + NADPH
sulfide + NADP+ + H2O
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reduction of sulfite by reduced methyl viologen is catalyzed by hemoprotein subunit alone
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-
?
sulfide + NADP+ + H2O
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no physiological nitrite reductase
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-
?
?
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the enzyme catalyzes the reduction of sulfite to sulfide
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-
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additional information
?
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the enzyme catalyzes the reduction of sulfite to sulfide
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additional information
?
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the enzyme catalyzes the reduction of sulfite to sulfide
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additional information
?
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transfer of hydrogen from NADPH to 3-acetylpyridineadenine dinucleotide phosphate
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-
?
additional information
?
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transfer of hydrogen from NADPH to 3-acetylpyridineadenine dinucleotide phosphate
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-
?
additional information
?
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transfer of hydrogen from NADPH to 3-acetylpyridineadenine dinucleotide phosphate
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-
?
additional information
?
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reduction of sulfite, nitrite, and hydroxylamine by NADPH requires catalytic activities of both subunits, reduction of sulfite, nitrite, and hydroxylamine by methyl viologen requires hemoprotein subunit
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-
?
additional information
?
-
-
reduction of sulfite, nitrite, and hydroxylamine by NADPH requires catalytic activities of both subunits, reduction of sulfite, nitrite, and hydroxylamine by methyl viologen requires hemoprotein subunit
-
-
?
additional information
?
-
-
reduction of sulfite, nitrite, and hydroxylamine by NADPH requires catalytic activities of both subunits, reduction of sulfite, nitrite, and hydroxylamine by methyl viologen requires hemoprotein subunit
-
-
?
additional information
?
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reactions catalyzed by flavoprotein subunit alone: transfer of electrons from NADPH to cytochrome c, ferricyanide, dichlorphenolindophenol, menadione, FMN, FAD, O2
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-
?
additional information
?
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reactions catalyzed by flavoprotein subunit alone: transfer of electrons from NADPH to cytochrome c, ferricyanide, dichlorphenolindophenol, menadione, FMN, FAD, O2
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-
?
additional information
?
-
-
reactions catalyzed by flavoprotein subunit alone: transfer of electrons from NADPH to cytochrome c, ferricyanide, dichlorphenolindophenol, menadione, FMN, FAD, O2
-
-
?
additional information
?
-
-
reactions catalyzed by flavoprotein subunit alone: transfer of electrons from NADPH to cytochrome c, ferricyanide, dichlorphenolindophenol, menadione, FMN, FAD, O2
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-
?
additional information
?
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can generate tyrosil radicals e.g. for transfer of electrons to the iron center of metR2, small subunit of ribonucletide reductase
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-
?
additional information
?
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transfer of hydrogen from NADPH to 3-acetylpyridineadenine dinucleotide phosphate
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-
?
additional information
?
-
-
reduction of sulfite, nitrite, and hydroxylamine by NADPH requires catalytic activities of both subunits, reduction of sulfite, nitrite, and hydroxylamine by methyl viologen requires hemoprotein subunit
-
-
?
additional information
?
-
-
reactions catalyzed by flavoprotein subunit alone: transfer of electrons from NADPH to cytochrome c, ferricyanide, dichlorphenolindophenol, menadione, FMN, FAD, O2
-
-
?
additional information
?
-
-
reactions catalyzed by flavoprotein subunit alone: transfer of electrons from NADPH to cytochrome c, ferricyanide, dichlorphenolindophenol, menadione, FMN, FAD, O2
-
-
?
additional information
?
-
-
reactions catalyzed by flavoprotein subunit alone: transfer of electrons from NADPH to cytochrome c, ferricyanide, dichlorphenolindophenol, menadione, FMN, FAD, O2
-
-
?
additional information
?
-
-
reactions catalyzed by flavoprotein subunit alone: transfer of electrons from NADPH to cytochrome c, ferricyanide, dichlorphenolindophenol, menadione, FMN, FAD, O2
-
-
?
additional information
?
-
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by production of the population synchronizer H2S involved in ultradian metabolic oscillation
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-
?
additional information
?
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transfer of hydrogen from NADPH to 3-acetylpyridineadenine dinucleotide phosphate
-
-
?
additional information
?
-
-
transfer of hydrogen from NADPH to 3-acetylpyridineadenine dinucleotide phosphate
-
-
?
additional information
?
-
-
reduction of sulfite, nitrite, and hydroxylamine by NADPH requires catalytic activities of both subunits, reduction of sulfite, nitrite, and hydroxylamine by methyl viologen requires hemoprotein subunit
-
-
?
additional information
?
-
-
reduction of sulfite, nitrite, and hydroxylamine by NADPH requires catalytic activities of both subunits, reduction of sulfite, nitrite, and hydroxylamine by methyl viologen requires hemoprotein subunit
-
-
?
additional information
?
-
-
reactions of FMN depleted enzyme
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-
?
additional information
?
-
-
reactions catalyzed by flavoprotein subunit alone: transfer of electrons from NADPH to cytochrome c, ferricyanide, dichlorphenolindophenol, menadione, FMN, FAD, O2
-
-
?
additional information
?
-
-
reactions catalyzed by flavoprotein subunit alone: transfer of electrons from NADPH to cytochrome c, ferricyanide, dichlorphenolindophenol, menadione, FMN, FAD, O2
-
-
?