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1.8.1.4: dihydrolipoyl dehydrogenase

This is an abbreviated version!
For detailed information about dihydrolipoyl dehydrogenase, go to the full flat file.

Word Map on EC 1.8.1.4

Reaction

protein N6-(dihydrolipoyl)lysine
+
NAD+
=
protein N6-(lipoyl)lysine
 +
NADH
 +
H+

Synonyms

apicoplast E3, CDS, CIP50, coronin-interacting protein, dehydrogenase, lipoamide, dehydrolipoate dehydrogenase, DHLDH, DHLipDH, diaphorase, dihydrolipoamide dehydrogenase, dihydrolipoamide dehydrogenase E3, dihydrolipoamide:NAD+ oxidoreductase, dihydrolipoic dehydrogenase, dihydrolipomide dehydrogenase, dihydrolipoyl dehydrogenase, DLD, DLD1, Dld2, DLDH, DLDH dehydrogenase, DLDH diaphorase, DLDH2, DT-diaphorase, E3, E3 component, E3 component of 2-oxoglutarate dehydrogenase complex, E3 component of acetoin cleaving system, E3 component of alpha keto acid dehydrogenase complexes, E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes, E3 component of pyruvate complex, E3 lipoamide dehydrogenase, E3 protein component of 2-oxoacid dehydrogenase multienzyme complexes, E3 subunit of the alpha-ketoglutarate dehydrogenase complex, EC 1.6.4.3, Glycine cleavage system L protein, Glycine oxidation system L-factor, hDLDH, hE3, hLADH, L-protein, LAD, LADH, LDH, LDP-Glc, LDP-Val, LipDH, lipoamide dehydrogenase, lipoamide dehydrogenase (NADH), lipoamide dehydrogenase C, lipoamide dehydrogenase2, lipoamide oxidoreductase (NADH), lipoamide reductase, lipoamide-dehydrogenase-valine, lipoate dehydrogenase, lipoic acid dehydrogenase, lipoyl dehydrogenase, LPD, LPD-GLC, LPD-VAL, LPD1, LPD2, Lpd3, LpdA, LpdC, LpdG, LpdV, More, mtLPD2, NAD(P)H:lipoamide oxidoreductase, NADH dehydrogenase, NADH diaphorase, NADH:lipoamide oxidoreductase, nicotinamide adenine dinucleotide diaphorase, ORF-E3, pdhD, pdhL, PfaE3, rhDLDH, TAase, ubiquinone reductase

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.1 With NAD+ or NADP+ as acceptor
                1.8.1.4 dihydrolipoyl dehydrogenase

Substrates Products

Substrates Products on EC 1.8.1.4 - dihydrolipoyl dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(R,S)-lipoamide + NADH + H+
dihydrolipoamide + NAD+
show the reaction diagram
-
-
-
-
r
1,4-benzoquinone + NADH
1,4-benzoquinol + NAD+
show the reaction diagram
1-methoxyphenazinium methosulfate + NADH
? + NAD+
show the reaction diagram
2 ferricyanide + NADH
2 ferrocyanide + NAD+ + H+
show the reaction diagram
2 ferricytochrome c + NADH
2 ferrocytochrome c + NAD+ + H+
show the reaction diagram
-
cytochrome c is a poor electron acceptor, only in presence of methylene blue the enzyme shows some activity
-
-
?
2,6-dichlorophenolindophenol + NADH + H+
reduced 2,6-dichlorophenolindophenol + NAD+
show the reaction diagram
2,6-dimethoxy-1,4-benzoquinone + NADH
? + NAD+
show the reaction diagram
8.0% activity compared to lipoamide
-
-
?
2,6-dimethyl-1,4-benzoquinone + NADH
2,6-dimethyl-1,4-benzoquinol + NAD+
show the reaction diagram
2-(p-iodophenyl)-3-p-nitrophenyl-5-phenyltetrazolium chloride + NADH
? + NAD+
show the reaction diagram
2-hydroxy-1,4-benzoquinone + NADH
2-hydroxy-1,4-benzoquinol + NAD+
show the reaction diagram
-
-
-
-
?
2-methyl-1,4-benzoquinone + NADH
2-methyl-1,4-benzoquinol + NAD+
show the reaction diagram
-
-
-
-
?
2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide + NADH
?
show the reaction diagram
3-nitrotyrosine + dihydrolipoic acid
3-aminotyrosine + lipoic acid + H2O
show the reaction diagram
3-nitrotyrosine + NAD(P)H
3-aminotyrosine + NAD(P)+ + H2O
show the reaction diagram
-
-
-
-
?
3-nitrotyrosine + NADPH
3-aminotyrosine + NADP+ + H2O
show the reaction diagram
-
-
-
-
?
3-nitrotyrosine + ubiquinol
3-aminotyrosine + ubiquinone + H2O
show the reaction diagram
5,5'-dithiobis-(2-nitrobenzoic acid) + NADH + H+
? + NAD+
show the reaction diagram
5-hydroxy-1,4-naphthoquinone + NADH
5-hydroxy-1,4-naphthoquinol + NAD+
show the reaction diagram
-
-
-
-
?
5-nitroblue tetrazolium chloride + NADH
? + NAD+
show the reaction diagram
-
5.1% of the activity with lipoamide
-
-
?
8-nitroguanine + dihydrolipoic acid
8-aminoguanine + lipoic acid + H2O
show the reaction diagram
8-nitroguanine + NAD(P)H
8-aminoguanine + NAD(P)+ + H2O
show the reaction diagram
-
-
-
-
?
8-nitroguanine + NADPH
8-aminoguanine + NADP+ + H2O
show the reaction diagram
-
-
-
-
?
8-nitroguanine + ubiquinol
8-aminoguanine + ubiquinone + H2O
show the reaction diagram
8-nitroxanthine + dihydrolipoic acid
8-aminoxanthine + lipoic acid + H2O
show the reaction diagram
8-nitroxanthine + NAD(P)H
8-aminoxanthine + NAD(P)+ + H2O
show the reaction diagram
-
-
-
-
?
8-nitroxanthine + NADPH
8-aminoxanthine + NADP+ + H2O
show the reaction diagram
-
-
-
-
?
8-nitroxanthine + ubiquinol
8-aminoxanthine + ubiquinone + H2O
show the reaction diagram
acetaldoxime + NADH
?
show the reaction diagram
alpha-lipoamide + NADH
dihydrolipoamide + NAD+
show the reaction diagram
alpha-lipoamide + NADH + H+
dihydrolipoamide + NAD+
show the reaction diagram
alpha-lipoic acid + NADH + H+
dihydrolipoic acid + NAD+
show the reaction diagram
benzyl viologen + NADH
? + NAD+
show the reaction diagram
-
2.9% of the activity with lipoamide
-
-
?
coenzyme Q-10 + NADPH
ubiquinol + NADP+
show the reaction diagram
dihydrolipoamide + NAD+
lipoamide + NADH
show the reaction diagram
dihydrolipoamide + NAD+
lipoamide + NADH + H+
show the reaction diagram
dihydrolipoamide + NADP+
lipoamide + NADPH
show the reaction diagram
-
-
-
r
dihydrolipoate + NAD+
lipoate + NADH + H+
show the reaction diagram
-
-
-
-
r
dihydrolipoic acid + NAD+
lipoic acid + NADH + H+
show the reaction diagram
-
-
-
?
DL-6,8-thiooctic acid amide + NADH
? + NAD+
show the reaction diagram
-
-
-
-
r
DL-alpha-lipoamide + NADH
dihydrolipoamide + NAD+
show the reaction diagram
-
-
-
-
?
DL-lipoamide + NADH
DL-dihydrolipoamide + NAD+
show the reaction diagram
DL-lipoamide + NADH + H+
DL-dihydrolipoamide + NAD+
show the reaction diagram
DL-lipoate + NADH
? + NAD+
show the reaction diagram
-
-
-
-
?
DL-lipoylbutanoate + NADH
? + NAD+
show the reaction diagram
-
-
-
-
?
DL-lipoylpentanoate + NADH
? + NAD+
show the reaction diagram
-
100fold reaction by the enzyme in two-electron-reduced state compared to the enzyme in four-electron-reduced state
-
-
?
ferrileghemoglobin + NADH + H+
ferroleghemoglobin + NAD+
show the reaction diagram
-
-
-
r
ferrocene + NADH
? + NAD+
show the reaction diagram
3.6% activity compared to lipoamide
-
-
?
ferrocenecarboxylic acid + NADH
? + NAD+
show the reaction diagram
4.1% activity compared to lipoamide
-
-
?
formaldoxime + NADH
?
show the reaction diagram
glycerol trinitrate + NADH
?
show the reaction diagram
hexacyanoferrate + NADH
? + NAD+
show the reaction diagram
-
-
-
-
?
hydroxylamine hydrochloride + NADH
?
show the reaction diagram
iodonitrotetrazolium + NADH
? + NAD+
show the reaction diagram
-
-
-
-
?
iodonitrotetrazolium chloride + NADH
? + NAD+
show the reaction diagram
19.3% activity compared to lipoamide
-
-
?
lipoamide + 3-acetylpyridine adenine dinucleotide
dihydrolipoamide + ?
show the reaction diagram
-
-
-
-
?
lipoamide + NADH
dihydrolipoamide + NAD+
show the reaction diagram
lipoamide + NADH + H+
dihydrolipoamide + NAD+
show the reaction diagram
lipoamide + nicotinamide hypoxanthine dinucleotide
dihydrolipoamide + ?
show the reaction diagram
-
-
-
-
?
lipoamide + thio-NADH
dihydrolipoamide + thio-NAD+
show the reaction diagram
-
-
-
-
?
lipoate + NADH + H+
dihydrolipoate + NAD+
show the reaction diagram
-
-
-
-
r
lipoic acid + NADH
dihydrolipoic acid + NAD+
show the reaction diagram
lipoic acid + NADH + H+
dihydrolipoic acid + NAD+
show the reaction diagram
lipoyl H-protein + NADH + H+
dihydrolipoyl H-protein + NAD+
show the reaction diagram
-
-
-
-
r
mature frataxin + NADH
denoted frataxin + NAD+
show the reaction diagram
menadione + NADH
? + NAD+
show the reaction diagram
methylene blue + NADH
? + NAD+
show the reaction diagram
methylene blue + NADH + H+
reduced methylene blue + NAD+
show the reaction diagram
metmyoglobin + NADH
reduced myoglobin + NAD+
show the reaction diagram
-
myoglobin is a poor electron acceptor, only in presence of methylene blue the enzyme shows some activity
-
-
?
NADH + H+ + oxidized 2,6-dichlorophenolindophenol
NAD+ + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
NADPH + H+ + oxidized 2,6-dichlorophenolindophenol
NADP+ + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
-
-
-
-
?
naphthoquinone + NADH
1,4-naphthoquinol + NAD+
show the reaction diagram
nitrated DNA + NAD(P)H
?
show the reaction diagram
-
enzyme reduces DNA nitro adducts including 8-nitroguanine, 3-nitrotyrosine, and 8-nitroxanthine, which formed in presence of peroxynitrite and nitryl chloride present in inflamed tissues, the nitrated DNA adducts are unstable and undergo spontaneous depurination which can cause cancer, enzyme might be resonsible for reversing biological nitration processes
-
-
?
nitrated DNA + NADPH
DNA + NADP+ + H2O
show the reaction diagram
-
enzyme reduces DNA nitro adducts including 8-nitroguanine, 3-nitrotyrosine, and 8-nitroxanthine, which formed in presence of peroxynitrite and nitryl chloride present in inflamed tissues, the nitrated DNA adducts are unstable and undergo spontaneous depurination
-
-
?
nitric oxide + NADH
nitrate + NAD+
show the reaction diagram
-
-
-
-
?
nitro blue tetrazolium + NADH
? + NAD+
show the reaction diagram
nitrotetrazolium blue + NADH
? + NAD+
show the reaction diagram
2.9% activity compared to lipoamide
-
-
?
nitrotetrazolium blue + NADH + H+
reduced nitrotetrazolium blue + NAD+
show the reaction diagram
-
-
-
-
r
O2 + NADH
?
show the reaction diagram
O2 + NADH
H2O2 + NAD+
show the reaction diagram
O2 + NADH + H+
H2O2 + NAD+
show the reaction diagram
-
-
-
-
?
oxidized 2,6-dichlorophenolindophenol + NADH
? + NAD+
show the reaction diagram
oxidized lipoamide + NADH
reduced lipoamide + NAD+
show the reaction diagram
-
-
-
-
?
oxidized lipoic acid + NADH
reduced lipoic acid + NAD+
show the reaction diagram
-
-
-
-
?
phenazine-1-carboxylic acid + NADH + H+
reduced phenazine-1-carboxylic acid + NAD+
show the reaction diagram
protein N6-(dihydrolipoyl)lysine + NAD+
protein N6-(lipoyl)lysine + NADH + H+
show the reaction diagram
-
-
-
-
?
protein N6-(lipoyl)lysine + NADH + H+
protein N6-(dihydrolipoyl)lysine + NAD+
show the reaction diagram
pyocyanin + NADH + H+
reduced pyocyanin + NAD+
show the reaction diagram
pyocyanin is reported to stimulate respiration
-
-
?
pyruvate + NADH
?
show the reaction diagram
-
-
-
-
?
reduced DL-lipoamide + NAD+
oxidized DL-lipoamide + NADH
show the reaction diagram
-
-
-
-
r
reduced lipoamide + NAD+
oxidized lipoamide + NADH
show the reaction diagram
resazurin + NADH
? + NAD+
show the reaction diagram
155.8% activity compared to lipoamide
-
-
?
resorufin + NADH
? + NAD+
show the reaction diagram
19.1% activity compared to lipoamide
-
-
?
S-nitroso-N-acetylpenicillamine + NADH
?
show the reaction diagram
S-nitrosoglutathione + NADH
?
show the reaction diagram
sodium nitroprusside + NADH
?
show the reaction diagram
sulfonated tetrazolium WST-1 + NADH
formazan derivative + NAD+
show the reaction diagram
39.2% activity compared to lipoamide
-
-
?
tellurite + NADH
NAD+ + ?
show the reaction diagram
thio-NAD+ + NADH
thio-NADH + NAD+
show the reaction diagram
ubiquinone + NAD(P)H
ubiquinol + NAD(P)+
show the reaction diagram
ubiquinone-10 + NAD(P)H
ubiquinol-10 + NAD(P)+
show the reaction diagram
vitamin K5 + NADH
?
show the reaction diagram
-
-
-
-
?
additional information
?
-