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1.8.1.5: 2-oxopropyl-CoM reductase (carboxylating)

This is an abbreviated version!
For detailed information about 2-oxopropyl-CoM reductase (carboxylating), go to the full flat file.

Word Map on EC 1.8.1.5

Reaction

2-mercaptoethanesulfonate
+
acetoacetate
+
NADP+
=
2-(2-oxopropylthio)ethanesulfonate
+
CO2
+
NADPH
+
H+

Synonyms

2-ketopropyl coenzyme M oxidoreductase/carboxylase, 2-ketopropyl-coenzyme M oxidoreductase/carboxylase, 2-KPCC, More, NADPH:2-(2-ketopropylthio)ethanesulfonate oxidoreductase/carboxylase, NADPH:2-ketopropyl-coenzyme M carboxylase/oxidoreductase, NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase, NADPH:2-ketopropyl-CoM oxidoreductase/carboxylase, xecC

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.1 With NAD+ or NADP+ as acceptor
                1.8.1.5 2-oxopropyl-CoM reductase (carboxylating)

Inhibitors

Inhibitors on EC 1.8.1.5 - 2-oxopropyl-CoM reductase (carboxylating)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-bromoethanesulfonate
-
reversible inhibitor, time-dependent inactivator of dithiothreitol-reduced 2-ketopropyl-CoM carboxylase/oxidoreductase, where the redox active cysteines are in the free thiol forms, does not inactivate air-oxidized 2-ketopropyl-CoM carboxylase/oxidoreductase, where the redox active cysteine pair is in the disulfide form. Inactivation leads to covalent modification of the interchange thiol residue C82. The flavin thiol Cys87 is not alkylated by 2-bromoethanesulfonate under reducing conditions, and no amino acid residues are modified by 2-bromoethanesulfonate in the oxidized enzyme
acetoacetate
mixed noncompetitive inhibition
bromoethanesulfonate
-
-
N-ethylmaleimide
-
-