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1.8.1.7: glutathione-disulfide reductase

This is an abbreviated version!
For detailed information about glutathione-disulfide reductase, go to the full flat file.

Word Map on EC 1.8.1.7

Reaction

2 glutathione +

NADP+
=
glutathione disulfide
 +
NADPH
 +
H+

Synonyms

At3g54660, EC 1.6.4.2, GLR, glutahione reductase, glutathione disulfide reductase, glutathione reductase, glutathione reductase (NADPH), glutathione reductase 3, glutathione reductase Glr1, glutathione S-reductase, glutathione: NADP(+) oxidoreductase, glutathione: NADP+ oxidoreductase, glutathione:NADP+ oxidoreductase, Gor, GOR1, GOR2, GR, GR1, GR2, Gr3, GRase, GRase-1, GRd, GSH reductase, GSHR, Gsr, GSR-1, GSSG reductase, HCOI_01258400, hGR, HvGR1, HvGR2, multifunctional thioredoxin-glutathione reductase, NADPH-glutathione reductase, NADPH-GSSG reductase, NADPH-reduced GR, NADPH: oxidized glutathione oxidoreductase, NADPH:oxidized glutathione oxidoreductase, NADPH:oxidized-glutathione oxidoreductase, OBP29, PfGR, psgr, PtGR1.1, PtGR1.2, PtGR2, reductase, glutathione, SpGR, TaGR1, TaGR2, TGR, thioredoxin glutathione reductase, thioredoxin/glutathione reductase, TrxR3

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.1 With NAD+ or NADP+ as acceptor
                1.8.1.7 glutathione-disulfide reductase

Metals Ions

Metals Ions on EC 1.8.1.7 - glutathione-disulfide reductase

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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Cd2+
-
0.05 mM, 2fold stimulation
diphosphate
-
activates
Fe3+
stimulates, AC50 value: 0.327 mM. Enzymatic activity in the presence of nontoxic iron (0.87 and 3 ppm) is activated, no changes are seen in the presence of toxic iron concentrations (30 and 300 ppm)
KBr
-
below 0.1 M
KCl
-
IC50: 0.51 M
KH2PO4
-
below 0.1 M
Mn2+
-
activates
Na+
-
activates
NaBr
-
activates
NaF
-
below 0.1 M
NH4+
-
activates
NH4Cl
-
below 0.1 M
phosphate
selenium
-
regulates the enzyme expression pattern, enzyme contains a catalytic selenocysteine
SO42-
-
stimulates
Sodium acetate
-
activates
Sodium citrate
-
activates
Sodium phosphate
-
activates
Zn2+
-
glutathione reductase is non-competitively inhibited up to 2 mM and activated above this concentration
additional information