1.8.1.9: thioredoxin-disulfide reductase

This is an abbreviated version!
For detailed information about thioredoxin-disulfide reductase, go to the full flat file.

Reaction

Synonyms

all0737, ApTR, At2g41680, AtNTRA, AtNTRB, bacillithiol disulfide reductase, bacillithiol-disulfide reductase, BBOV_I002190, Bdr, BSSB reductase, CeTR2, DmTR, DmTrxR, DmTrxR-1, EC 1.6.4.5, EhTRXR, ferredoxin:thioredoxin reductase, FTR, general stress protein 35, GSP35, HCOI_01258400, hemolysate thioredoxin reductase, hemolysate TR, hTrxR, HvNTR1, HvNTR2, L-TR, L-TrxR, More, MtNTRC, mTR3, multifunctional thioredoxin-glutathione reductase, NAD(P)H:paraquat oxidoreductase, NADP-dependent thioredoxin reductase, NADP-linked thioredoxin reductase, NADP-thioredoxin reductase, NADP-thioredoxin reductase C, NADPH thioredoxin reductase, NADPH thioredoxin reductase C, NADPH-dependent thioredoxin reductase, NADPH-dependent thioredoxin reductase 2, NADPH-dependent thioredoxin reductase C, NADPH-dependent thioredoxin reductase I, NADPH-dependent thioredoxin reductase-1, NADPH-dependent TRX reductase, NADPH-thioredoxin reductase, NADPH-thioredoxin reductase C, NADPH-Trx reductase, NADPH2:oxidized thioredoxin oxidoreductase, NAPDH-dependent BSSB reductase, NTR, Ntr1, NTR2, Ntr3, NTRA, NTRAB, NtrB, NTRC, PH0178, PH1426, PhRP, PhTrxR, protein-disulfide oxidoreductase, reductase, thioredoxin, SEP1, taTrxR, TGR, thioredoxin glutathione reductase, thioredoxin h reductase, thioredoxin reductase, thioredoxin reductase (NADPH), thioredoxin reductase 1, thioredoxin reductase 2, thioredoxin reductase-1, thioredoxin reductase1, TON_1603, TR, TR1, TR2, TR3, TRase, TrR, Trr1, Trr1p, TRR2, Trx1, Trx3, TrxB, TrxB1, TrxB2, TrxR, TrxR-1(cyto), TrxR-1(mito), TrxR1, TrxR2, TrxR3, TrxRB3, TRXRD, TrxRh1, TrxRh2, TrxT, Txnrd1, TXNRD1-v3, Txnrd2, TXNRD3, TxrR-1, YpdA

ECTree

     1 Oxidoreductases

         1.8 Acting on a sulfur group of donors

             1.8.1 With NAD⁺ or NADP⁺ as acceptor

                1.8.1.9 thioredoxin-disulfide reductase

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Results	in table
30	Activating Compound
46939	AA Sequence
16	Application
1	CAS Registry Number
85	Cloned(Commentary)
336	Cofactor
23	Crystallization (Commentary)
2680	Disease/ Diagnostics
17	Expression
90	General Information
3	General Stability
171	IC50 Value
338	Inhibitors
94	kcat/KM [mM/s]
18	Ki Value [mM]
247	KM Value [mM]
128	Localization
56	Metals/Ions
111	Molecular Weight [Da]
97	Natural Substrates/ Products (Substrates)
492	Organism
2	Oxidation Stability
4	Pathway
197	PDB ID
36	pH Optimum
7	pH Range
1	pH Stability
8	pI Value
3	Posttranslational Modification
115	Protein Variants
109	Purification (Commentary)
31	Reaction
5	Reaction Type
344	Reference
261	Source Tissue
68	Specific Activity [micromol/min/mg]
1	Storage Stability
640	Substrates and Products (Substrate)
93	Subunits
546	Synonyms
1	Systematic Name
20	Temperature Optimum [°C]
1	Temperature Range [°C]
11	Temperature Stability [°C]
194	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 1.8.1.9 - thioredoxin-disulfide reductase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

carbon tetrachloride

Mus musculus

Q9JMH6

causes marked increases in hepatic TrxR1 activity

690139

cysteine

17 entries

EDTA

3 entries

FADH2

Fasciola hepatica

-

activates

659779

KCN

Escherichia coli

-

-

394931

phosphate

2 entries

Thioacetamide

Mus musculus

Q9JMH6

causes marked increases in hepatic TrxR1 activity

690139

cysteine

Arabidopsis thaliana

-

part of the active site

394932

cysteine

Bos taurus

-

C-terminal redox active selenocysteine motif

394952

cysteine

Cereibacter sphaeroides

-

part of the active site

394916

cysteine

Drosophila melanogaster

-

C-terminal redox active disulfide

394947, 394949

cysteine

Drosophila melanogaster

-

part of the active site

394947

cysteine

Escherichia coli

-

2 pairs of cysteine residues, C32, C35 and C135, C138

394946

cysteine

Escherichia coli

-

part of the active site

394918

cysteine

Escherichia coli

-

1 redox-active disulfide per subunit

394933

cysteine

Homo sapiens

-

C-terminal redox active disulfide

394947

cysteine

Homo sapiens

-

part of the active site

394939, 394941, 394947

cysteine

Plasmodium falciparum

-

C-terminal redox active disulfide

394947

cysteine

Plasmodium falciparum

-

part of the active site

394947

cysteine

Plasmodium falciparum

-

1 pair of redox active cysteines at the N-terminal active center and 1 pair of selenenylsulfide at the C-terminus, crucial for the reduction of thioredoxin

394938

cysteine

Plasmodium falciparum

-

at the active center, C88 and C93

394943

cysteine

Rattus norvegicus

-

part of the active site

394921, 394942

cysteine

Triticum aestivum

Q8VX47

-

394937

cysteine

Triticum aestivum

-

part of the active site

394925

EDTA

Bos taurus

-

4% activity remaining without

394952

EDTA

Homo sapiens

-

if the concentration of EDTA in the reaction mixture is higher than 0.1 mM the enzyme shows full activity

674618

EDTA

Mus musculus

-

if the concentration of EDTA in the reaction mixture is higher than 0.1 mM the enzyme shows full activity

674618

phosphate

Escherichia coli

-

2fold activation

393993

phosphate

Homo sapiens

-

under growth conditions

394954